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Tumor necrosis factor (TNF) was long cast as a hematopoiesis villain, driving bone marrow and hematopoietic stem cell (HSC) suppression. We now see that TNF's effects are cell type-, context-, and time-dependent. Rather than being simply "bad," TNF can prune progenitors while transiently reprogramming HSCs without sacrificing long-term regenerative capacity.
Denna kunskapsöversikt sammanfattar effekterna av olika boendeinsatser för att motverka hemlöshet. Kunskapsöversikten har tagits fram genom en överenskommelse med Socialstyrelsen. Översikten är en uppdatering av rapporten Boendelösningar för hemlösa personer – en kunskapsöversikt, som Socialstyrelsen publicerade 2009. Underlaget består av 96 vetenskapligt granskade studier publicerade efter 2009,
Rebecca Yarros’s Fourth Wing (2023) is a romantasy novel with a complex dragon society where dragons’ personalities, tempers and looks vary and affect each other. It is a new work of fiction, the first book in her still unfinished Empyrean series, and thus not many have had the chance to explore and discuss it in a formal capacity. The previous discussion is mainly made up of book reviews, and the
A key aspect of imperialism, colonialism, and capitalism is frontier-making. Frontiers are essential for ambitions of appropriation and extraction. This paper explores the discursive practices of frontier-making in Scandinavia including the conceptualization of parts of this region as empty space and ripe for exploitation, as wild, unruly and in need of domestication. These regions have historical
BACKGROUND: Drug-coated balloons (DCB) are frequently used during percutaneous coronary intervention. Despite this there are limited data from studies comparing different types of DCB, particularly for a paclitaxel-coated balloon (PCB) using urea as the excipient. This study aimed to assess the clinical efficacy of the PCB with urea compared with other frequently used DCB, attempting to emulate a
Presents a two-dimensional stochastic convection-diffusion model for use in real-time prediction of the space-time rainfall structure in urban areas. The model is used to parameterize the rainfall intensity from individual rain cells. Especially, we are interested to quantify the rainfall intensity resulting from different separable components of the rain cell. This is done by a Lagrangian approac
Anastomotic defect (AD) after esophagectomy can lead to severe complications with need for surgical or endoscopic intervention. Early detection enables early treatment and can limit the consequences of the AD. As of today, there are limited methods to predict AD. In this study, we have used microdialysis (MD) to measure local metabolism at the intrathoracic anastomosis. Feasibility and possible di
Brain tumours are among the most common cancer diagnoses in paediatrics. Children with brain tumours are at risk of developing sleep problems because of direct and indirect effects of the tumour and its treatment, in addition to psychosocial and environmental factors. Sleep has an important role in physical and psychological wellbeing, and sleep problems are associated with many adverse outcomes.
ObjectivesAn endovascular aneurysm repair (EVAR) graft is a catheter-implanted vascular prosthesis and is the preferred treatment for patients with aortic aneurysm. If an EVAR graft becomes the focus of infection, the treatment possibilities are limited as it is technically difficult to remove the graft to obtain source control. This study examines whether Pseudomonas aeruginosa and Staphylococcus
Responding to perceived threats is energetically expensive and can require animals to curtail somatic repair, immunity, and even reproduction to balance energy ledgers. In birds and mammals, energetic demands of thermoregulation are often immense, yet whether homeostatic body temperatures are also compromised to aid the stress response is not known. Using data sourced from over 60 years of literat
Atherosclerosis, the underlying pathology of cardiovascular diseases such as myocardial infarction and ischemic stroke, is characterized by chronic inflammation. T cells are present in atherosclerotic plaques and have been implicated in its pathogenesis. This thesis describes studies exploring both the regulation of T cells in atherosclerosis as well as immunomodulatory therapeutics. To study the
We examined the effect of 17alpha-ethinylestradiol on immunity of the Western fence lizard, Sceloporus occidentalis. Injection of 17alpha-ethinylestradiol resulted in dose-dependent suppression of peripheral blood leukocyte levels as determined by cell counts, whereas total spleen cell levels were decreased only at higher doses of 17alpha-ethinylestradiol. In contrast, spleen cell proliferation wa
The F-FCSR stream cipher family has been presented a few years ago. Apart from some flaws in the initial propositions, corrected in a later stage, there are no known weaknesses of the core of these algorithms. The hardware oriented version, called FCSR-H, is one of the ciphers selected for the eSTREAM portfolio. In this paper we present a new and severe cryptanalytic attack on the F-FCSR stream
Helicobacter pylori is a major factor for the development of gastric cancer. The aim of this study was to define serum antibody patterns associated with H. pylori infection in patients with gastric cancer using a Western blot technique. Serum samples collected from 115 patients with gastric cancer and 110 age- and gender-matched patients without gastrointestinal diseases were tested for IgG antibo
