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Relative telomere length (RTL), an indicator of senescence, has been shown to be heritable but can also be affected by environmental factors, such as parental effects. Investigating heritability as well as parental effects and rearing environment can help us to understand the factors affecting offspring telomeres. Moreover, how phenotypic parental traits linked with fitness can impact offspring RT
Purpose/Objective(s): To report the efficacy and utility of PSMA-based molecular targeted imaging in localized prostate cancer using 111In-J591 SPECT and 89Zr-J591 immuno-PET.Materials/Methods: Initiated in 2010, two sequential phase 0 prospective studies were performed on a total of 19 patients evaluating the roles of 111In-J591 SPECT and 89Zr-J591 immuno-PET. All patients had a baseline MRI foll
Transitioning from linear to circular production systems requires interactions that include cross-sectoral collaboration in networks. Understanding the role of collaboration within these networks can support the transition to a circular economy. To understand cross-sectoral collaborative endeavors, this paper develops a collaboration framework for circular economy by combining and interlinking thr
Chronotypes describe consistent differences between individuals in biological time-keeping. They have been linked both with underlying variation in the circadian system and fitness. Quantification of chronotypes is usually by time of onset, midpoint, or offset of a rhythmic behaviour or physiological process. However, diel activity patterns respond flexibly to many short-term environmental influen
Objectives: The primary aim of this review was to investigate neurocognitive outcomes following out-of-hospital cardiac arrest (OHCA). Specifically, the focus was on identifying the different neurocognitive domains that are assessed, the measures used, and the level of, and criteria for, impairment. Design and review methods: A systematic review of the literature from 2006 to 2021 was completed us
Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to psychobiology. A systematic review of the literature reveals that blood cf-mtDNA varies in response to common real-world stressors including psychopathology, acute psychological stress, and exercise. Moreover, cf-mtDNA is inducible within minute
BACKGROUND: A large proportion of adult survivors of cardiac arrest have a poor neurological outcome. Guidelines recommend multimodal neuro-prognostication no earlier than 72-96 hours after cardiac arrest. There is great interest in earlier prognostic markers, including very early markers at admission. The novel blood biomarkers proenkephalin A 119-159 (penKid), bioactive adrenomedullin (bio-ADM)
A tacit assumption in the field of consciousness studies is that the more empirical evidence a theory can explain, the better it fares when weighed against competitors. If one wants to take seriously the potential for empirical evidence to move forward debates in consciousness studies, there is a need to gather, organize, validate, and compare evidence. We present an inference to the best explanat
At field strengths of 7 T and above, T1-weighted imaging of human brain suffers increasingly from radiofrequency (RF) B1 inhomogeneities. The well-known MP2RAGE (magnetization prepared two rapid acquisition gradient echoes) sequence provides a solution but may not be readily available for all MR systems. Here, we describe the implementation and evaluation of a sequential protocol to obtain normali
In the outskirts of nearby spiral galaxies, star formation is observed in extremely low gas surface densities. Star formation in these regions, where the interstellar medium is dominated by diffuse atomic hydrogen, is difficult to explain with classic star formation theories. In this letter, we introduce runaway stars as an explanation for this observation. Runaway stars, produced by collisional d
Astrocytes form functionally and morphologically distinct populations of cells with brain-region-specific properties. Human pluripotent stem cells (hPSCs) offer possibilities to generate astroglia for studies investigating mechanisms governing the emergence of astrocytic diversity. We established a method to generate human astrocytes from hPSCs with forebrain patterning and final specification wit
The diversity among Swedish university students is steadily increasing. The students have different backgrounds, experiences, interests, learning styles and abilities. Also, there are more students with disabilities at Swedish universities, especially invisible disabilities. Teachers need to adapt their teaching and curricula, and can no longer wait to do this until they spot a student with divers
Collagen type II (CII)-induced arthritis (CIA) in mice is a model for rheumatoid arthritis (RA) in which the role of T lymphocytes remains controversial. To clarify this, we have bred a targeted gene deletion of TCR beta or delta loci into two mouse strains susceptible to CIA, the B10.Q and DBA/1 strains. The TCRbeta-/- mice lacked alphabeta T cells, which was compensated by an expansion of B cell
Transgenic techniques in inbred mouse strains are powerful tools to investigate the specific roles of genes in biological pathways and disease models. However, there is increasing concern over the influence of a variable genetic background in such experiments. To date there have been few investigations of the immunological differences between inbred mouse strains used in models of autoimmune disea
Atomic oxygen (O) is vital in plasma-assisted combustion, but its quantitative measurement is challenging and therefore rarely reported. This work performs femtosecond two-photon-absorption laser-induced fluorescence (fs-TALIF) imaging to quantify the dynamics of atomic oxygen production by a single nanosecond (ns) pulsed plasma discharge in an ammonia/air flame for the first time. First of all, t
This chapter unpacks the complex and contested nature of ‘irregular labour migration’ and explores the meaning and analytical rigour of this conceptualisation. We discuss four social positions: 1) authorised migrant regular worker, 2) authorised migrant irregular worker, 3) unauthorised migrant irregular worker and 4) unauthorised migrant regular worker. Using the distinctions between informalisat
Previous research has shown that class differences in adult mortality in the study area emerged only in the mid-twentieth century. Such findings question a universal association between socioeconomic status and mortality. This chapter examines whether these class differences in adult mortality emerged at the same time in urban as in rural areas. The analysis shows that the social class gradient in
This article aims to examine the nexus between social media, anti-corruption activism and democratisation in authoritarian regime contexts. It will investigate the complex ways in which civil society actors utilise art and humour on social media platforms to engage in covert anti-corruption activism. In doing so, we will show how, in authoritarian contexts, digital (social media) activists creativ
