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Maternal vaccination, resulting in transfer of protective IgG across the placenta, represents a promising strategy to prevent neonatal disease caused by group B Streptococcus (GBS). The prototype vaccine GBS-NN, a fusion protein consisting of the N-terminal domains of the alpha-like protein (Alp) family members AlphaC and Rib, has been shown to display a good safety profile and to elicit a strong

Pregnancy-induced immune modulation might lead to reactivation of latent tuberculosis infection (LTBI). This thesis explores aspects of immune-based LTBI diagnostics and how pregnancy affects the immune control of Mycobacterium tuberculosis (Mtb) infection. We studied a prospective cohort of women recruited during pregnancy in Ethiopia. LTBI testing was performed by quantification of interferon-γ

This paper serves as a detailed research proposal for a newly started PhD-project concerning multimetal craftsmanship in the Scandinavian later Iron Age. The project employs landscape survey, material and archaeometallurgical analysis of metallurgical debris, and a theoretical framework grounded in economic theory to counter fundamental key questions surrounding metalworking, metalworkers, and the

This chapter examines the response of five prominent Swedish economists, David Davidson, Gustav Cassel, Eli Heckscher, Knut Wicksell and Bertil Ohlin, to John Maynard Keynes’s The Economic Consequences of the Peace and to the German reparations in the 1920s. When Keynes’s book appeared, Davidson and Cassel strongly endorsed it. Heckscher also agreed with Keynes in a long review entitled “Too Bad t

BACKGROUND: Early glottic cancer can be treated with laser resection or radiotherapy. In an earlier study, we found that voice function after laser resection was inferior to that after radiotherapy.OBJECTIVES: This study was designed to determine if reduced margins at laser resection improved voice function without impairing oncologic results.METHOD: A total of 268 patients with previously untreat

What does it take to make a customer return? René van Pelt and Ida de Wit Sandström are retail workers in the specialist jewellery trade. They have been serving their customers together for more than fifteen years. In a world where digitalisation is changing the business conditions, demands regarding distinction and profiling are increasing and consumers are becoming ever more unpredictable , show

This paper examines the profound impact of digital technology on Classical and Mediterranean archaeology, with a focus on digital field recording and infrastructure. Using the 'skeuomorphism of practice' framework, it traces the integration of technology into our current practice. The Swedish Pompeii project is used as a case study to illustrate the adoption of 3D models into traditional archaeolo

BACKGROUND AND AIMS: Systolic blood pressure (SBP) drops recorded by 24-hour ambulatory blood pressure (BP) monitoring (ABPM) identify patients with susceptibility to reflex syncope and orthostatic intolerance. We tested the hypothesis that treatments aimed to increase BP (reassurance, education & life-style measures plus pharmacological strategies) can reduce SBP drops.METHODS: Multicentre, o

To investigate multimodal signals in cat–human communication we recorded 36 cat–owner interactions in everyday situations that were judged by the owners for valence (negative, mixed or positive). We then coded the videos for behaviour using an ethogram including vocal, visual and tactile (multimodal) signals. Vocalisations were segmented and acoustic measures of duration and F0 obtained. In cats,

Neuroblastoma (NB) is a heterogeneous childhood cancer, characterized by the amplification of the MYCN oncogene in 40% of the high-risk cases. Our previous work demonstrated that MYCN drives metabolic reprogramming in NB, including upregulation of antioxidant enzymes. Here, we identify peroxiredoxin 6 (PRDX6) as a promising therapeutic target in NB. Pharmacological inhibition of PRDX6 reduces MYCN

Background The health of people with functional variation in Sweden is worse than people without functional variation. A health-promoting resource in adults’ lives is meaningful employment, and for people with functional variation it means some form of daily activity. The project "Grow with horsepower" is a person-centered and nature-oriented daily activity for people with function variation, who

Self-adaptation enables software to execute successfully in dynamic, unpredictable, and uncertain environments. However, most of the current approaches lack formal guarantees on the effectiveness and dependability of the adaptation mechanisms, limiting their applicability in practice. Control theory established a broad set of mathematically grounded techniques for the control of dynamic systems fo

In 2005, Pachon et al.1 proposed cardiac vagal denervation to treat neurally mediated syncope. Since then, a metanalysis of observational studies2 and a recent randomized controlled trial (RCT)3 have provided some evidence that cardioneuroablation (CNA) is able to prevent syncope recurrence at least during the first 2 years following the procedure in patients affected by reflex syncope. In brief,

Receptors, transporters, and ion channels are important targets for therapy development in neurological diseases, but their mechanistic role in pathogenesis is often poorly understood. Gene editing and in vivo imaging approaches will help to identify the molecular and functional role of these targets and the consequence of their regional dysfunction on the whole-brain level. We combine CRISPR-Cas9

This chapter examines the complex relationship between social enterprises and taxation. The focus is not on a specific country, although various examples are mentioned. As specific tax measures for social enterprises are a form of tax incentives, the chapter discusses this public finance concept. In addition, an important legal constraint on introducing such incentives for social enterprises in th