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Following the EU declaration from 2016 on schools as the most crucial places for societal change needed in order to strengthen democracy, this chapter discusses Nordic music education and music education research within the context of shared challenges in times of rapid demographic changes. Resting on emerging results from the authors’ research projects, the first theme to be discussed is music ed
A conspicuous feature of the amyotrophic lateral sclerosis (ALS)-associated protein SOD1 is that its maturation into a functional enzyme relies on local folding of two disordered loops into a catalytic subdomain. To drive the disorder-to-order transition, the protein employs a single Zn2+ ion. The question is then if the entropic penalty of maintaining such disordered loops in the immature apoSOD1
In general, a natural aquifer has a hydrogeologically non-uniform structure. The movement of pollutants in groundwater is affected by such structural properties during transport by local advection and microscopic dispersion. The macroscopic dispersion coefficient increases linearly with travel distance or travel time at the initial stage after the pollutant is released, and then converges asymptot
Accurate detection and identification are essential components for epidemiological, ecological, and evolutionary surveys of avian haemosporidian parasites. Microscopy has been used for more than 100 years to detect and identify these parasites; however, this technique requires considerable training and high-level expertise. Several PCR methods with highly sensitive and specific detection capabilit
In 2007, Roman Shukhevych (1907–1950), the commander of the Ukrainian Insurgent Army (UPA), was designated an official Ukrainian state hero. He has since become the object of an elaborate cult of personality. Lauded for his resistance to the Soviet authorities in 1944–1950, Shukhevych is highly controversial in neighbouring Poland for the ethnic cleansing that the UPA carried out in 1943–1944, as
Purpose: To evaluate the access to human rights of persons with disabilities who use prosthetic and orthotic assistive devices, and to compare groups of participants in terms of gender, residential area, income, and type and level of assistive device. The addressed areas were rights to: health, a standard of living adequate for health, education, marry and establish a family, vote, and work. Metho
Background: We sought to assess the influence of the clinical introduction of new radiotherapy technologies on glioblastoma patients’ outcomes. Methods: Newly diagnosed glioblastoma patients treated with 60 Gy and temozolomide (2005–2014) were analyzed. The patients’ GTV and CTV were defined based on MR (n = 521) or FET-PET/MR (n = 190), and were treated using conformal radiotherapy (CRT, n = 159)
Background: Recurrence in glioblastoma patients often occur close to the original tumour and indicates that the current treatment is inadequate for local tumour control. In this study, we explored the feasibility of using multi-modality imaging at the time of radiotherapy planning. Specifically, we aimed to identify parameters from pre-treatment PET and MRI with potent
Recent advances in high-throughput sequencing technologies uncovered widespread RNA modifications on coding and non-coding RNAs collectively refer to as the epitranscriptome. However, we are only now starting to appreciate the impact of the epitranscriptome in regulating cell biology. Among more than 150 RNA modifications, I focused on pseudouridine (Ψ) the most abundant single-nucleoside RNA modi
Dijets are produced in abundance at the Large Hadron Collider as predicted by quantum chromodynamics (QCD). However, several theories beyond the Standard Model of Particle Physics predicts new phenomena, which also result in dijet final states. This thesis presents searches for such new phenomena using different techniques. One approach is to look for jets, that originate from top quarks. We know,
Full-field transmission X-ray microscopy (TXM) is a well established technique, available at various synchrotron beamlines around the world as well as by laboratory benchtop devices. One of the major TXM challenges, due to its nanometre-scale resolution, is the overall instrument stability during the acquisition of the series of tomographic projections. The ability to correct for vertical and hori
Structural Health Monitoring (SHM) has been a subject of major international research in Civil Engineering structures mainly during the last 20 years. While in the beginning, SHM mainly focused on sensor developments, nowadays practical implications regarding the acquisition, collecting and processing of data are being addressed. Indeed, SHM systems have been evolving along the two last decades an
Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from large-scale resources. Here we explore the relationship between genetic variants influencing predisposition to type 2 diabetes (T2D) and related glycemic trai
Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short-term overfeeding. Therefore, we hypothesized that the actin-driven myocardin-related transcription factor (MRTF-A) contributes to impaired mature
A modification to our previous simulation of breast anatomy is proposed to improve the quality of simulated x-ray projections images. The image quality is affected by the voxel size of the simulation. Large voxels can cause notable spatial quantization artifacts; small voxels extend the generation time and increase the memory requirements. An improvement in image quality is achievable without redu
Background: Stroke is one of the leading causes of death, and out of all stroke cases, 10-15% originate from a previously asymptomatic stenosis in the internal carotid artery. Aims: The aim of the study was to investigate whether dietary and lifestyle habits were associated with future risk of incident carotid artery disease (CAD). Methods: Baseline examinations on middle-aged individuals (n = 30,
Background: Empowered women have improved decision-making capacity and can demand equal access to health services. Community-based interventions based on building women’s groups for awareness generation on maternal and child health (MCH) are the best and cost-effective approaches in improving their access to health services. The present study evaluated a community-based intervention aimed at impro
