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To explore the largely unknown etiology of small intestine cancer, we examined metabolic factors and risk of small intestine cancer overall and by subtypes. Among 404 220 women and 403 265 men in six European cohorts, we applied Cox regression with adjustment for smoking and body mass index (BMI), to calculate sex-specific hazard ratios (HRs) of small intestine cancer by levels of BMI, mean arteri
Evaluation of Article 17(7) and (9) Directive 2019/790 on copyright in the Digital Single Market (DSM Directive) establishing an interface between the obligations of online content-sharing service providers in Article 17(1)-(4) DSM Directive, and the European system of limitations in Article 5 Directive 2001/29 (InfoSoc Directive). Part I, published on the Kluwer Copyright Blog.
We investigate the complex conductivity behaviour of natural volcanic rocks containing variable amounts of smectite in multi-salinity experiments. We compare the results with relationships established for sandstones. Considering only samples with little volume of metallic particles, we observe similar and small phase-angles at low frequency for all samples at all salinities (less than 25 mrad at 1
Differences between 10Be records from Greenland and Antarctica over the last 100 years have led to different conclusions about past changes in solar activity. The reasons for this disagreement remain unresolved. We analyze a seasonally resolved 10Be record from a firn core (North Greenland Eemian Ice Drilling [NEEM] ice core project) in Northwestern Greenland for 1887–2002. By comparing the NEEM d
The chronology of post-last Glacial Maximum dceglaciation in the northern Antarctic Peninsula region is discussed. It is concluded that, contrary to what was earlier believed, the deglaciation process here was largely out-of-phase with that in the Northern Hemisphere. Although, for global eustatic reasons, the marine-based glaciers may have retreated simultaneously with ice-melting in the Northern
Regional development is a dynamic process where relatively stable periods are interrupted by phases of more rapid transformation and disruption. Such dynamics are heavily influenced by the scope and nature of knowledge networks. Trust is a key mechanism influencing the mobilisation of networks for learning and innovation and thereby an important factor for understanding regional development. This
Purpose: A degenerative meniscus lesion is a slowly developing process typically involving a horizontal cleavage in a middle-aged or older person. When the knee is symptomatic, arthroscopic partial meniscectomy has been practised for a long time with many case series reporting improved patient outcomes. Since 2002, several randomised clinical trials demonstrated no additional benefit of arthroscop
The core feature of vascular ageing is the age-associated stiffening of the large, elastic arteries, or arteriosclerosis. This results in a diminished volume-buffering function and is therefore central for the increase in systolic blood pressure and pulse pressure seen with advancing age. Since there are considerable individual differences regarding the rate of vascular ageing, the aim was to desc
The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness and vertigo and on caloric and postrotatory nystagmus were evaluated in healthy volunteers. TTS-scopolamine was administered transdermally (delivering approximately 10 micrograms X h-1 scopolamine base) and 100 mg dimenhydrinate orally. Lidocaine and tocainide were administered intravenously (average plasma
Calcitonin gene-related peptide (CGRP) is a 37 amino acid neuropeptide with several functions including vasodilation, the perception of painful stimuli, and inflammation. The CGRP receptor consists of two main components; calcitonin-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1). While there is a growing recognition that CGRP plays a key role in migraine, the function of CGR
Purpose A degenerative meniscus lesion is a slowly developing process typically involving a horizontal cleavage in a middle-aged or older person. When the knee is symptomatic, arthroscopic partial meniscectomy has been practised for a long time with many case series reporting improved patient outcomes. Since 2002, several randomised clinical trials demonstrated no additional benefit of arthroscopi
In this article, I focus on cultural communication between Finland and Sweden,exemplified by sport-related texts from Swedish newspapers and magazines at the turn of the twentieth century. At that particular point in time, the linguistic barrier between the two nations was relatively easy to breach (which will be problematized further). This enabled an exchange to take place, which helped to shape
Nuclear medicine uses radioactive pharmaceuticals for diagnostic or therapeutic purposes. The ionizing radiation emitted from the radiopharmaceutical is partially absorbed within the patient's body and internal dosimetry is the method to estimate the absorbed dose to a tumour or risk organ. This is of special importance in radiopharmaceutical therapy (RPT), where particle-emitting radionuclides ar
OBJECTIVE: To assess the progression of type 1 diabetes using time to peak glucose or C-peptide during oral glucose tolerance tests (OGTTs) in autoantibody-positive relatives of people with type 1 diabetes. RESEARCH DESIGN AND METHODS: We examined 2-h OGTTs of participants in the Diabetes Prevention Trial Type 1 (DPT-1) and TrialNet Pathway to Prevention (PTP) studies. We included 706 DPT-1 partic
The European Copernicus programme plans to install a constellation of multiple polar orbiting satellites (Copernicus Anthropogenic CO2 Monitoring Mission, CO2M mission) for observing atmospheric CO2 content with the aim to estimate fossil fuel CO2 emissions. We explore the impact of potential CO2M observations of column-averaged CO2 (XCO2), nitrogen dioxide (NO2), and aerosols in a 200 × 200 km2 d
Advanced maternal age at birth is considered a risk factor for adverse birth outcomes. A recent study applying a sibling design has shown, however, that the association might be confounded by unobserved maternal characteristics. Methods: Using total population register data on all live singleton births during the period 1999-2012 in Denmark (N = 580-133; 90% population coverage), Norway (N = 540-8
