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Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the m

In this thesis I have discussed the possibility of building a stable and long-lasting peace in a state whose society is considered to be deeply divided ? Bosnia and Herzegovina. The main question to be answered by this study was Which factors facilitate and which factors obstruct stable and long-lasting peace in a deeply divided society? I have examined the post-war constitutional design of Bosnia

Summary Anti-neutrophil cytoplasmic antibodies against proteinase 3 (PR3-ANCA) are used as diagnostic tools for patients with small vessel vasculitis (AASV). We have produced chimeric mouse/human PR3 molecules and investigate changes in reactivity over time and the possible relationship between epitope specificity and clinical course. Thirty-eight PR3-ANCA-positive patients diagnosed between 1990

Två förslag till en bättre publiceringsverksamhet vid Område HT och vid Lunds universitet. Rapport från projektet HT-områdets bokpubliceringar. Rapporten innehåller förutom de två förslagen också kort historisk bakgrund, nationell och skandinavisk jämförelse och inventering av HT-forskarnas publiceringar. Dessutom sammanfattas två väsentliga internationella diskussioner: hur universitetsförlagen

Decision making is a dynamic process. Alternatives compete over time, and this competition plays out in sensorimotor processes. This is true not just for perceptual decisions or simple categorisation tasks, but also for moral decisions, which are the outcome of a complex interplay of intuition, emotion and reasoning. In this experiment, we first establish a descriptive and causal link between gaze

On site remote laser-induced fluorescence measurements have been performed with application towards non-movable objects. This paper describes the application of non-invasive hyperspectral fluorescence imaging to two masonry monuments, the Coliseum and the Lateran Baptistery in Rome, during a joint Italian-Swedish experiment. The mobile systems of Lund Institute of Technology, Sweden, and CNR-IFAC,

Popular Abstract in Swedish Det finns en skillnad mellan historia som vetenskap och historia som historiskt minne, som boken vill fästa uppmärksamhet på. Ådalen som motbild till det trygga Folkhemmet är en bild av hur vi kan uppleva verkligheten. Inte nödvändigtvis hur den såg ut. Vår uppfattning om vad som hänt kan vaa nog så verklig när vi handlar, agerar och tolkar omvärlden. Det är denna tolknThe prelude to this thesis is provided by the dramatic scenes that took place in Ådalen. During a demonstration, four men and one young woman were shot to death and five others injured by military troops ordered to Lunde harbour. Inspired by a number of other researchers (Koselleck, Samuel, Somers, Stråth, Södring, Jensen and Burke, to name a few), my investigation has analysed how the story of th

Our ever-changing world has to a great extent created a need of efficient financial risk-management programs for financial institutions and corporations operating in a demanding international environment. These changes have however also increased the types of financial tools and derivatives used to handle the multifold macroeconomic exposures. Companies have therefore diversified opportunities to

Groundwater, as a vital water resource in arid and semi-arid regions, plays a crucial role in sustaining human livelihoods, agriculture, and industry. Over recent decades, these areas have witnessed rapid groundwater depletion, raising concerns about resource sustainability. This research provides a comprehensive analysis of the factors contributing to the decline in groundwater levels (GWL) withi

Universities have long used internationalization to prepare students for a highly interconnected world. Although internationalization has often been associated with mobility, current calls for equity, diversity, and inclusion, and climate consciousness, among other things, require institutions to change this strategy. As a response, curriculum internationalization emerges as a more inclusive and s

Agriculture is widely recognized as critical to achieving the Sustainable Development Goals (SDGs), but researchers, policymakers, and practitioners have multiple, often conflicting yet poorly documented priorities on how agriculture could or should support achieving the SDGs. Here, we assess consensus and divergence in priorities for agricultural systems among research, policy, and practice persp

Gebel el-Silsila displays an astounding concentration of incised illustrations, of which anthropomorphic figures are frequent motifs. These figures were produced over several millennia; from prehistoric petroglyphs to pictorial graffiti of dynastic periods and throughout into Roman days. Spanning over six millennia visitors to Gebel el Silsila depicted huntsmen, warriors, boatmen, and horsemen, reGebel el Silsila displays an astounding concentration of incised illustrations, of which anthropomorphic figures are frequent motifs. These figures were produced over several millennia: from prehistoric petroglyphs to pictorial graffiti of dynastic periods and throughout into Roman days. Spanning over six millennia visitors to Gebel el Silsila depicted huntsmen, warriors, boatmen, and horsemen, re

Geospatial data are increasingly available nowadays, and this leads to more analyses and visualisation of geospatial data from several sources. To enable this, we need homogenous data as well as proper integration methods. Geospatial data integration has been a longstanding research topic for decades, and this paper discusses the utilisation of Linked Data technology stack to alleviate the geospat

A major challenge in evolutionary biology is to understand how complex traits of multiple functions have diversified and codiversified across interacting lineages and geographic ranges. We evaluate intra- and interspecific variation in floral scent, which is a complex trait of documented importance for mutualistic and antagonistic interactions between plants, pollinators, and herbivores. We perfor

Road Safety Audits (RSA) and Road Safety Inspections (RSI) are effective means of Road Infrastructure Safety Management. They are preventive tools, consisting of systematic, safety assessments, carried out by trained, independent safety expert teams, resulting in a formal report on detected road hazards and safety issues, requiring a formal response by the relevant road authority. Yet, current reg