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Sports-Related Traumatic Brain Injury

The speed and intensity of modern sports puts the athlete at risk for impacts to the head, or to the body when the impact force is transmitted to the head. Rapid head rotation caused by these impact forces may lead to a sports-related concussion (SRC), defined as a mild traumatic brain injury, typically resulting in short-lived disturbance of the central nervous system function. The diagnosis of S

MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM

Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, metastasis, and resistance to therapy. Clinical development of Met-targeted antibodies has been challenging, however, as bivalent antibodies exhibit agoni

Firefighters as first responders in out-of-hospital cardiac arrest : A retrospective study of a time-gain selective dispatch system in the Skåne Region, Sweden

AimTo analyze the impact of a time-gain selective, first-responder dispatch system on the presence of a shockable initial rhythm (SIR), return of spontaneous circulation (ROSC) and 30-day survival after out-of-hospital cardiac arrest (OHCA).MethodA retrospective observational study comprising OHCA registry data and dispatch data in the Skåne Region, Sweden (2010–2018). Data were categorized accord

Claims in the clinic: tensions in healthcare communication about perceived side effects of the copper IUD

A large share of health-related information is today sought and communicated via the internet, including in social media. Questions have been raised about how this may affect health perceptions and behaviors, not least by enabling the communication of claims that contradict information from established medical authorities. As an example, knowledge claims about systemic side effects of the contrace

The first comprehensive population size estimations for the highly endangered largest diving beetle Dytiscus latissimus in Europe

Dytiscus latissimus (Coleoptera Dytiscidae) is an endangered diving beetle throughout its range. It is one of the two species of Dytiscidae listed in Annex II of the Habitats Directive, IUCN red list and in many national level legislations and therefore strictly protected. The conservation of endangered species first of all requires an assessment of their population size. Until now, a method has n

Host shift and natural long-distance dispersal to an oceanic island of a host-specific parasite

Parasite dispersal and host-switching may be better understood by knowing when they occurred. We estimated when the ancestor of a parasite of great reed warblers (Acrocephalus arundinaceus) dispersed to the Seychelles and began infecting the endemic Seychelles warbler (A. sechellensis). We used mitochondrial genomes and published molecular divergence rates to estimate the date of divergence betwee

A critical typology of "good place branding" : Lessons from place-branding expertise

Place branding is defined as “the development of brands for geographic locationswith the aim of triggering positive associations about the area and distinguishinga place from other places” (Stevens et al., 2020, p. 752). Like all occupations,place branding is organised by discourses, or talk, that determine best practices andnorms about what constitutes expertise (Loacker and Sullivan, 2016). Expl

Formation and photoluminescence of Ge and Si nanoparticles encapsulated in oxide layers

Ge and Si semiconductor nanoparticles encapsulated in oxide layers were prepared by the inert gas condensation method. High-resolution electron microscopy and energy dispersive X-ray spectrometry showed the formation of the core-shell structures with a size below 10 nm. The optical absorption spectra of Ge showed the band edges at higher energy compared to the ordinary Ge element. Photoluminescenc

Digitalization: A Potential Tool for Sustainable Consumption?

Given the outsized impact that digitalization has had on consumption over the last two decades, the lack of academic interest in sustainable consumption is noteworthy. In this book chapter, we set the scene for the fundamentally important discussion about how digitalization affects consumption. We ask whether digitalization is a positive or a negative force for shaping consumption levels and patte

From Great Novels to Jantsch/Prigogine, Ken Wilber and Stephen Wolfram. Erland Lageroth's Homepage

"Search is our greatest adventure" (Rolf Edberg). Join me in this adventure and experience the same joy, enlightment, and insight that this journey of discoveries during 50 years has given me! The journey, way, narrative begins with criticism of fiction and goes via rethinking of literary research, humanities, and natural science to the discovery of a "humanistic" natural science, a "world philos

Born Near the Limit of Viability : Developmental Outcomes 2.5 Years Later

Popular Abstract in Swedish Bakgrund Neonatal intensivvård är under ständig utveckling, vilket medfört att allt mindre barn överlever efter att ha fötts prematurt. Ett tydligt mått på detta är att gränsen för livsduglighet (den gestationsålder då individen beräknas ha 50% chans att överleva) har skjutits bakåt till att under de senaste två decennierna ligga runt graviditetsvecka 24. Barn som föds Although advances in neonatal care have resulted in increased survival rates among extremely preterm infants (born < 28 gestational weeks), they still face substantial morbidity risks during the neonatal period. The question of possible later outcomes is a key issue faced by health care professionals working with these infants. Objectives The objective of the present thesis was to explore develo

Semantics and cognition : Spatiotemporal metaphors and time perception in L2 users

This chapter reviews the available empirical evidence for a universal metaphoric structure such as TIME IS SPACE and its effects on temporal cognition in L2 users. The chapter covers previous experimental evidence that lends support to the psychological reality of the TIME IS SPACE metaphor, while also revealing cross-linguistic differences in how this fundamental metaphor is instantiated across t

Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

Background/Objectives: Motor impairment induced by traumatic brain injury (TBI) may be mediated through changes in spinal molecular systems regulating neuronal plasticity. We assessed whether a focal controlled cortical impact (CCI) TBI in the rat alters expression of the Tgfb1, c-Fos, Bdnf, and Gap43 neuroplasticity genes in lumbar spinal cord. Approach/Methods: Adult male Sprague-Dawley rats (n