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The airway epithelium as regulator of inflammation patterns in asthma

Introduction: Asthma is a complex, heterogeneous and mutifactorial disease and represents a major health problem in Westernised countries. The airway epithelium, with its direct physical contact with luminal triggers, has a major role in determining the nature of inflammation that develops in asthmatic airways. Objective: The present review aims to provide a brief overview of the numerous ways the

Impact of cell wall-degrading enzymes on water-holding capacity and solubility of dietary fibre in rye and wheat bran.

BACKGROUND: Rye and wheat bran were treated with several xylanases and endoglucanases, and the effects on physicochemical properties such as solubility, viscosity, water-holding capacity and particle size as well as the chemical composition of the soluble and insoluble fractions of the bran were studied. A large number of enzymes with well-defined activities were used. This enabled a comparison be

Internal water and microsecond dynamics in myoglobin.

Myoglobin (Mb) binds diatomic ligands, like O2, CO, and NO, in a cavity that is only transiently accessible. Crystallography and molecular simulations show that the ligands can migrate through an extensive network of transiently connected cavities but disagree on the locations and occupancy of internal hydration sites. Here, we use water (2)H and (17)O magnetic relaxation dispersion (MRD) to chara

Autobiography and the psychological study of religious lives

This volume positions itself on the cutting edge of two fields in psychology that enjoy rapidly increasing attention: both the study of human lives and some core domains of such lives as religion and spirituality are high on the agenda of current research and teaching. Biographies and autobiographies are being approached in new ways and have become central to the study of human lives as an object