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Smoking and acute myeloid leukemia: associations with morphology and karyotypic patterns and evaluation of dose-response relations

This case-control study of tobacco smoking and acute myeloid leukemia (AML), emphasizing specific associations with morphologic and cytogenetic subtypes, comprised smoking histories for 333 cases and 351 controls. Smoking status (ever smokers versus life-long non-smokers) showed no evident effect on AML risk. However, an effect of smoking was indicated at high cumulative smoking doses (pack-years)

Parallel gene expression profiling of mantle cell lymphoma - How do we transform 'omics data into clinical practice

DNA microarray technology has been a valuable tool to provide a global view of the changes in gene expression that characterize different types of B cell lymphomas, both in relation to clinical parameters but also in comparison with the non-malignant counterparts. The number of transcripts that can be analyzed on an array has dramatically increased, and now most commercially available arrays cover

Tracking taphonomy. Analysis of skeletal remains from wild boar (Sus scrofa) and red deer (Cervus elaphus) from Mesolithic sites in Scania, Southern Sweden

This study is an effort to describe and analyse the taphonomic history of skeletal remains of wild boar (Sus scrofa) and red deer (Cervus elaphus) from six Mesolithic sites. Five methods have been used to analyse the effect of different taphonomic processes. A positive correlation between bone element frequency (%MAU) and structural bone density in all but one bone sample (Segebro) indicates high

The human antibody repertoire to infectious agents: implications for disease pathogenesis

Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A

Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice

Helicobacter pylori infection in humans is associated with chronic type B gastritis, peptic ulcer disease, and gastric carcinoma. A high intake of carotenoids and vitamin C has been proposed to prevent development of gastric malignancies. The aim of this study was to explore if the microalga Haematococcus pluvialis rich in the carotenoid astaxanthin and vitamin C can inhibit experimental H. pylori

Accelerated storage and isothermal microcalorimetry as methods of predicting carrot juice shelf-life

The possibility of predicting the shelf-life of pasteurized carrot juice by isothermal microcalorimetry or change in pH was investigated and compared with traditional plate count results. A small increase in thermal power (2 muW), maximal increase of and acceleration of thermal power all gave rapid, well-correlated results for the shelf-life, as did pH, during accelerated storage. The effect of ac

Transboundary transportation of CO2 streams by ships : regulatory barriers for scaling up carbon capture and sub-seabed storage

Over the years, Carbon Capture and Sequestration (CCS) has been recognized as a crucial element in the toolkit of measures to combat climate change. At the European Union (EU) level, CCS plays a vital role in climate policy, particularly in reducing CO2 emissions from hard-to-abate industries. However, no comprehensive legal framework covers all stages of CCS. These stages include carbon capture t

Molecular 3D Characterisation of Drug Distribution and Mg-Stearate Coating on Lactose Carrier Particles by ToF-SIMS and XPS

A common type of inhalation medicine uses a dry powder formulation where the active pharmaceutical ingredient (API) is attached on the surface of carrier particles, often in combination with additional components. The spatial distribution of the API on the carrier particle is critical for the release into the lungs and thus for the efficacy of the drug. In this work, we use ToF-SIMS imaging in com

Circulation, Arenas, and the Quest for Public Knowledge : Historiographical Currents and Analytical Frameworks

The recent surge in publications on the history of knowledge may obscure the fact that there are several parallel understandings of what the field is. In this article, I discern five major historiographical directions in contemporary scholarship regarding the history of knowledge. The analytical framework that has so far attracted the most attention is the circulation of knowledge. As productive a

Bacterial glycosidases in pathogenesis and glycoengineering.

ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobi

Degrowth

This article examines the idea of degrowth, a concept in political ecology used to envision a democratically planned downscaling of production and consumption in affluent regions of the world as a means to avoid ecological breakdown, decrease inequality, and improve quality of life. Since its inception at the beginning of the 2000s in France, the idea of degrowth has sparked a worldwide social mov