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HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded human alpha-lactalbumin and oleic acid that kills many different types of tumor cells and shows therapeutic efficacy in animal models and clinical studies. This thesis aims to (1) elucidate the structure of HAMLET and the exposure of biologically active domains, (2) define the contribution of lipids to t
Popular Abstract in Swedish Prostatacancer är en mycket vanlig form av cancer, och det har visats att cirka hälften av alla män över 70 år har tumör i prostata. Prostatacancer är ofta en latent form av cancer, vilket innebär att den sällan ger kliniska symtom förrän i ett framskridet stadium. Sedan PSA testet började användas på 90-talet har antalet diagnostiserade fall av prostatacancer blivit alProstate cancer is currently the most common form of cancer in Sweden. Currently, the only biomarker used in the clinic is serum PSA, and there is a great need for new biomarkers that may increase the diagnostic and prognostic information so that better predictions can be made, and treatment may be tailored. Here, we have investigated two proposed biomarkers microseminoprotein-β (MSMB) and cystein
The content of low molecular weight carbohydrates (LMWC, glucose, fructose, sucrose, raffinose, stachyose and verbascose) was investigated in 29 cultivars of vining peas after blanching and freezing. The peas were harvested at about the same degree of ripeness. There was a positive correlation between the amount of raffinose, stachyose and sorbitol, while a high content of verbascose only could be
There are many ways to realise a DP-internal possessor in Scandinavian. In some varieties, such as Standard Swedish and Standard Danish, all DP-internal possessors are prenominal. In other varieties, such as Faroese, Icelandic, and Norwegian, possessors can be either prenominal or postnominal. In the case of a pronominal possessor, prenominal position has to do with focus in these varieties. The s
Innovation and industrial dynamics have grown in importance over the last 40-50 years as we have moved towards a more knowledge intensive society. In an effort to understand these developments in society new research fields have emerged such as innovation and entrepreneurship studies. In general, these two research fields are regarded as rather closely interlinked. In this study we elaborate on th
In this paper we examine the ambiguities between extrinsic and intrinsic parameters in the uncalibrated structure and motion problem. The Jacobian J of the reprojection error is considered, treating each camera separately. Ambiguities correspond to linear dependencies in the column space of J and we thus detect and quantify these by using the condition number of selected combinations of columns of
Issues of sustainable agriculture have much relevance and urgency for the sustainable production of non-eatable products that have an agricultural origin, such as biofuels. In the chapter the opinion is expressed that joint legal regulations on sustainable use of natural resources and sustainable farming methods for eatable and non-eatable products of an agricultural origin can be an efficient sol
Galactose C3-triazole derivatives were synthesized by Cu(I)-catalyzed cycloaddition between acetylenes and galactose C3-azido derivatives. Evaluation against galectin-3, 7, 8N (N-terminal) and 9N (N-terminal) revealed 1,4-disubstituted triazoles to be high-affinity inhibitors of galectin-3 with selectivity over galectin-7, 8N, and 9N. Conformational analysis of 1,4-di-and 1,4,5-tri-substituted gal
Mitogenic effects of the extracellular nucleotides ATP and UTP are mediated by P2Y(1), P2Y(2), and P2Y(4) receptors. However, it has not been possible to examine the highly expressed UDP-sensitive P2Y(6) receptor because of the lack of stable, selective agonists. In rat aorta smooth muscle cells (vascular smooth muscle cells; VSMC), UDP and UTP stimulated (3)H-labeled thymidine incorporation with
