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We study the chemical evolution of Zr, La, Ce, and Eu in the Milky Way discs and bulge by means of chemical evolution models compared with spectroscopic data. We consider detailed chemical evolution models for the Galactic thick disc, thin disc, and bulge, which have been already tested to reproduce the observed [α/Fe] versus [Fe/H] diagrams and metallicity distribution functions for the three dif
INTRODUCTION: Despite much literature on reference values of acid-base status in umbilical cord blood at birth, there are as yet no studies performed to determine gestational age-dependent references in cord venous blood and no studies on preterm acid-base standards. Similarly, the normal reference range of Apgar scores for term and preterm infants has not yet been determined.MATERIAL AND METHODS:
The Huaibei Plain is one of the most severe water scarcity areas in China. Understanding of hydroclimatic variation in this area at different timescales and its relationship with global teleconnection patterns are important for assessment of water resources utilization. In this study, spatiotemporal changes of seasonal and annual precipitation and temperature, including trend, abrupt change, varia
In this paper we investigate the specific mechanisms of British financial influence in the Cape Colony during the diamond mining boom of the late nineteenth century. We do so by offering a detailed exposition of the uneasy marriage between the colonial state and private business sector in the context of the economics and dynamics of extractivism in the periphery. This allows us to encapsulate the
Background: Preeclampsia (PE) is a complex pregnancy syndrome characterised by maternal hypertension and organ damage after 20 weeks of gestation and is associated with an increased risk of cardiovascular disease later in life. Extracellular haemoglobin (Hb) and its metabolites heme and iron are highly toxic molecules and several defence mechanisms have evolved to protect the tissue. Objectives: W
The CRISPR/Cas9 system is a versatile tool for functional genomics and forward genetic screens in mammalian cells. However, it has been challenging to deliver the CRISPR components to sensitive cell types, such as primary human hematopoietic stem and progenitor cells (HSPCs), partly due to lentiviral transduction of Cas9 being extremely inefficient in these cells. Here, to overcome these hurdles,
CD59 is a glycosylphosphatidylinositol (GPI)-anchored cell surface inhibitor of the complement membrane attack complex (MAC). We showed previously that CD59 is highly expressed in pancreatic islets but is down-regulated in rodent models of diabetes. CD59 knockdown but not enzymatic removal of cell surface CD59 led to a loss of glucose-stimulated insulin secretion (GSIS), suggesting that an intrace
Aortic aneurysms are rare manifestations in children with tuberous sclerosis complex (TSC) with life threating implications. Although an association between TSC, aortic and other aneurysms has been recognized, mechanistic insights explaining the pathophysiology behind aneurysm development and genetic aberrations in TSC have so far been lacking. Here, we summarize existing knowledge on aneurysms in
This study aims to develop a theoretical and analytical approach for studying discretion, automated decision-making (ADM) and the consequential public values. This is achieved through our proposed approach, an overview of literature and an empirical test. The context of our empirical test is decisions made about economic support in social work. The research questions are as follows: 1) What are th
Background: While cognitive-behavioral therapy (CBT) is the gold-standard psychological treatment for major depression (MD), non-response and lacking stability of treatment gains are persistent issues. Potential factors influencing treatment outcome might be lifetime trauma history and possibly associated primarily prefrontal-cortex- and hippocampus-dependent cognitive alterations. Method: We inve
Investigating the optical properties of various chemical compounds using UV-vis spectrophotometers is an essential part of education in chemistry. However, commercial spectrophotometers are usually treated as "magic black boxes", where the dominant majority of optical elements are hidden "under the hood". This often limits understanding of the mechanisms behind the generation of spectral curves, w
Background: The software engineering community has expressed growing concern regarding the need for more connections between research and practice. Despite the large amount of knowledge researchers generate, its impact on real-world practice is uncertain. Meanwhile, practitioners in industry often struggle to access and utilize relevant research outcomes that could inform and enhance their work.
Most of the ecotoxicological research conducted in the Arctic until today has focused on long range transport of pollutants, while fewer studies on local pollution have been published. The aim of this study was hence to investigate if local pollution of organophosphorus flame retardants (OPFRs), polybrominated diphenyl ethers (PBDEs) and perfluorinated alkylated substances (PFAS) occurs outside tw
The European Union is often portrayed as a soft, civilian power. In this thesis we question this view of the Union, by comparing it to the United States of America; usually described as a hard power user. We compare the foreign policy actions of the EU and the US in the seventeen conflicts of 2004. With help from K. J. Holsti's division of strategies to exercise power we create our own tool fo
