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Cutaneous Human Papillomavirus (HPV) types have been associated with non-melanoma skin cancer (NMSC), including a previous nested case-control study using HPV serology with bacterially derived fusion proteins with the major HPV capsid protein L1 (GST-L1). However, HPV serology using conformationally intact pseudovirions has been shown to correlate better with natural infection. Prospective studies

This book provides important insights into the domain of interactions between language and cognition, focusing on SPACE and expressions of SPACE. Both literal and metaphorical forms of expression are included. The research reported is carried out within the broad framework of Cognitive Linguistics, which encompasses a wide variety of empirical methods and research topics. Our approach to the const

Popular Abstract in Swedish Det finns tre muskeltyper i människokroppen; skelettmuskler, hjärtmuskler och glatta muskler. Skelettmusklerna är de muskler som gör att vi kan röra oss och andas (mellangärdesmuskeln är en skelettmuskel). Hjärtmuskelcellerna är de som gör att hjärtat slår. Den glatta muskulaturen finns på många ställen i kroppen (t.ex. i blodkärl, luftvägar och livmoder) och utför mångThis thesis examines the cellular and molecular mechanisms involved in the large diversity of the contractile properties in smooth muscle. Six studies, I-VI, are included. I: a slow smooth muscle (aorta) has a different nucleotide and phosphate dependence compared to a fast type (taenia coli). A slow ADP-release can be one mechanism responsible for the lower shortening velocity of aorta. II: treat

The proper handling of alarms is crucial to automated process control. In practice, many alarms are only distractive and do not represent a fault situation. Here a toolbox, that uses an expert system called LARA, is proposed that aims to reduce the occurrence of so-called nuisance alarms. It is based on a signal classification scheme to propose suitable alarm handling algorithms according to the s

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerdiagnosen hos kvinnor, och under år 2011 fick över 8000 svenska kvinnor denna diagnos. Termen bröstcancer är egentligen ett samlingsnamn för alla de olika typer av cancer som kan uppstå i bröstet. En del typer av bröstcancer har en bra prognos medan andra trots aggressiv behandling alltjämt har en dålig prognos. Cancer är en sjukdom dBreast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) prote

Deterministic lateral displacement (DLD) is a powerful bimodal separation scheme [1] based on fluid flow through regular obstacle arrays that in its basic embodiment sends suspended particles in two different directions as a function of size. We show that without the need to seal devices and without the need for fluidic connections or pumps, particle separation can be achieved by the passive flow

Deterministic lateral displacement (DLD) is a powerful bimodal separation scheme [1] based on regular obstacle arrays that in its basic embodiment sends particles in two different directions as a function of size. We add functionality to the technique by including gravitational forces, as a perturbation to particles transported by fluid flow, and as a way of transporting the particles through a st

Conventional fractionation techniques fail to fully benefit from the variety in morphology and shape that is found among biological particles. Although light scattering in conventional FACS gives some information on the size and morphology of a particle, it is generally not capable of giving a definite number on specified dimensions of a small object. We demonstrate an approach where we select whi