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The BCR::ABL1 tyrosine kinase inhibitors (TKIs) in CML represent a paradigm for molecularly targeted therapy. However, clinical outcomes - rate/depth of response, treatment-free remission (TFR), progression to blast crisis (BC) - and adverse events vary among patients. While additional somatic mutations have been invoked to explain varying clinical outcomes, we here propose a complementary perspec

A supply chain is often complex in nature. Goods, information, and money shall flow in and between companies in a simple and cost effective manner. There are a number of tools that companies can use to control and manage the supply chain in an efficient manner. In this work, two types of IT-based tools are compared i.e integrated and best-of-breed solutions. The questions this work will try to ans

This paper establishes the difference between process and outcome differentiation, claiming that the former seems to have become reality in the European integration process. Concerning the outcome, the author claims that thus far the Union is legally defined by its actors to be a harmonisation project, serving the interests of EU citizens by means of an economic and increasingly political Union of

Photo-Fenton oxidation was used for treatment of synthetic textile wastewater as stand alone treatment, as pre-treatment before aerobic biological treatment and as post-treatment after anaerobic biological treatment. The processes were compared with regards to decolorization, chemical oxygen demand (COD) reduction and chemical consumption. When applying photo-Fenton alone for treatment of Remazol

The aim was to assess the risk of venous thromboembolism (VTE) associated with use of combined oral contraceptives (COCs) in women with a family history of VTE.

Plasminogen-activator inhibitor (PAI)-1 is an important inhibitor of the plasminogen/plasmin system. PAI-1 levels are influenced by the 4G/5G polymorphism in the PAI-1 promoter. We investigated the relationship between the PAI-1 polymorphism and VTE recurrence, and its possible modification by factor V Leiden (FVL) and prothrombin (PTM) mutations. Patients (n=1,069) from the Malmö Thrombophilia St

Popular Abstract in Swedish Balansen mellan våra energibehov och den energi som konsumeras är ej längre i jämvikt. Därför är jakten på alternativa energikällor nödvändig. Hållbara energikällor erbjuder ett bra alternativ till fossilbränslen. Bland många typer av hållbara energikällor erbjuder solenergi möjligheten för mer energi än dagens konsumtion. Solceller är de smarta verktyg som omvandlar ljThe balance between our demands of energy and the energy we are consuming is not in equilibrium anymore. Therefore, the search for other energy resources is indispensable. Sustainable energy sources offer the alternative to the fossil fuels. Within many types of sustainable energy sources, solar energy offers more than the total global energy consumption. Solar cells are the smart conversion tools

Globalization pressures have today inflicted significant changes in the way industrial enterprises are organized and how products are developed, manufactured and brought to market. A common denominator in many of these enterprises is the utilization of an organizational structure based on networks composed of divisions and supplier companies dispersed all over the world. ln these global enterprise

Occurrences of fire ignitions in a given region during a specified period of time are modelled as outcomes of a Poisson point process. The ignition frequency is considered a function of the total floor area of the building. Parameter estimates and their uncertainties are computed. Different criteria for model selection are used. The proposed methodology is specifically useful in the case with smal

An automated glucose feeding strategy that avoids acetate accumulationin cultivations of Escherichia coli is discussed. We havepreviously described how a probing technique makes it possible todetect and avoid overflow metabolism using a dissolved oxygen sensor.In this paper these ideas are extended with a safety net thatguarantees that aerobic conditions are maintained. The method isgenerally appl

When double-stranded DNA molecules are heated, or exposed to denaturing agents, the two strands are separated. The statistical physics of this process has a long history and is commonly described in terms of the Poland-Scheraga (PS) model. Crucial to this model is the configurational entropy for a melted region (compared to the entropy of an intact region of the same size), quantified by the loop

While cognitive ability is inversely associated with risk for schizophrenia (SZ), the association is less clear with other nonaffective psychoses (ONAP) and bipolar illness (BPI). Using national Swedish hospital registry data, we examined the prospective relationship between school achievement (SA) and development of SZ, ONAP, and BPI in 1800643 adolescents born 1972-1990. We used Cox proportional

The extension of DNA confined to nanochannels has been studied intensively and in detail. However, quantitative comparisons between experiments and model calculations are difficult because most theoretical predictions involve undetermined prefactors, and because the model parameters (contour length, Kuhn length, effective width) are difficult to compute reliably, leading to substantial uncertainti

Release planning for incremental software development assigns features to releases such that most important technical, resource, risk and budget constraints are met. The research presented in this paper is an element of a three-staged procedure. In addition to an existing method for (i) strategic release planning that maps requirements to subsequent releases and (ii) a more fine-grained planning t

Although drug abuse (DA) is strongly familial, with important genetic influences, we need to know more about the role of rearing environment in the risk for DA. To address this question, we utilized a high-risk adopted and non-adopted co-sibling control design.