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OBJECTIVE: To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).METHODS: Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted
Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoprotei
Ageing significantly alters the body in different ways, especially our perception and experience of it. In the phenomenological perspective, the human mind and body are intertwined with each other as well as intertwined with the surrounding world; consequently an altered body will affect the experience of both self and the world. This article discuss how and when ageing and old age affect the expe
The article provides an overview of ongoing research and key characteristics of Cognitive Semiotics, an emerging field dedicated to the transdiciplinary study of meaning, involving above all researchers from semiotics, linguistics, developmental and comparative psychology and philosophy. The combination of the following features distinguishes it from other synthetic approaches: (a) integration of
Prostate-specific antigen (PSA) testing has limited accuracy for the early detection of prostate cancer (PCa).
By studying the continuity between the Ottoman Empire and its succeeding Turkish Republic, this article aims to address one crucial aspect of the denial of the Armenian genocide by the Turkish state, namely the issue of state responsibility. There are psychological barriers in Turkey which have largely suppressed the memories of possible wrongdoings during World War I and the ensuing ‘Independence
Popular Abstract in Swedish Under Indonesiens auktoritära regim Den nya ordningen under president Suharto, avsågs det lilla nationalistkristna koalitionspartiet Indonesiska demokratiska partiet, PDI, spela rollen av ett regeringstroget statskorporatismiskt parti, vars existens skulle demonstrera regimens påstådda demokratiska karaktär. Från den senare hälften av 1980-talet började partiet emellertUnder Indonesia's authoritarian New Order regime of President Suharto, the role envisaged for the small nationalist-Christian coalition the Indonesian Democratic Party (PDI) was that of a pliant state corporatist party, the existence of which was meant to demonstrate the ostensibly democratic character of the regime. From the second half of the 1980s, however, the party began to develop in a criti
This book illustrates the program of Logical-Informational Dynamics. Rational agents exploit the information available in the world in delicate ways, adopt a wide range of epistemic attitudes, and in that process, constantly change the world itself. Logical-Informational Dynamics is about logical systems putting such activities at center stage, focusing on the events by which we acquire informatio
Dissipation of acoustic waves may be an efficient heating mechanism forthe lower and middle chromosphere of the quiet Sun. The basic idea isthat turbulent motions at the top of the solar convection zone generateacoustic waves which propagate upwards and dissipate in the lower andmiddle chromosphere, transporting energy into the higher layers. Butstill the question remains if this amount of energy
The United Nations (UN)-led global consultations on new development goals, which will replace the Millennium Development Goals (MDGs), started in 2012. In comparison with the creation of the MDGs, the road towards the post-2015 goals is much more inclusive and participatory. The consultations are part of a longer trend, in which intergovernmental organizations seek to strengthen their legitimacy
OBJECTIVE: To define a minimum Standard Set of outcome measures and case-mix factors for monitoring, comparing, and improving healthcare for patients with clinically diagnosed hip or knee osteoarthritis (OA) with a focus on defining the outcomes that matter most to patients. METHODS: An international Working Group (WG) of patients, arthroplasty register experts, orthopedic surgeons, primary care
Fission track analysis (FTA) was developed to be applied to ultra-low levels of 239Pu in bioassay samples. An analytical protocol was established for the FTA processing. The detection limit was determined to 1.5 µBq and the calibration constant was 24 fission fragments per µBq 239Pu. Naturally occuring nuclides of thorium and uranium, present in biological and environmental samples, did not interf
Consumers increasingly demand that brand authenticity means that the brand's values are aligned with the corporation's actions, which are made transparent (Holt 2002). Interrogating Holt's claim that "consumer resistance" is inevitably staged in the marketplace, I suggest that the implications of seeing brand authenticity as linked to trust are related to how the consumer's role on the market is p
The performance of the ALICE detector in searches for new heavy stable charged particles in pp collisions is discussed in this paper Gluino R-hadron was chosen as an example of a candidate, and cross sections and kinematic properties were obtained from PYTHIA simulations for various gluino masses (100 - 500 GeV/c(2)) Detector response simulations for R-hadrons in the TPC acceptance (vertical bar e
To provide a basis for the interpretation of past climatic conditions from Quaternary leaf records, leaf carbon isotope (delta C-13) results are presented for 12 northern European dwarf-shrub, shrub and tree species growing across a network of 18 sites in northern Scandinavia. The role of micro-habitat (hummock/hollow) on carbon isotope trends is explored in addition to a comparison of the carbon
Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A
