Filtyp
An integration of distributionally robust risk allocation into sampling-based motion planning algorithms for robots operating in uncertain environments is proposed. We perform non-uniform risk allocation by decomposing the distributionally robust joint risk constraints defined over the entire planning horizon into individual risk constraints given the total risk budget. Specifically, the determini
Ex vivo (outside of the body) working heart models enable the evaluation of isolated hearts. They are envisioned to play an important role in increasing the currently low utilization rate of donor hearts for transplantation. For the heart to work in isolation, an afterload (flow impedance) is needed. To date, afterload devices have been constructed by combining multiple constituent elements such a
Fast simulation of linear time-invariant (LTI) pharmacokinetic (PK) models is crucial to mixed-effect modeling techniques, used extensively in pharmacological research and development. The by far most common LTI PK models are particularly structured compartmental systems with one, two or three compartments. Here we develop and demonstrate very efficient, and down to machine precision exact, simula
We apply two sparse reconstruction techniques, the least absolute shrinkage and selection operator (LASSO) and the sparse exponential mode analysis (SEMA), to two-dimensional (2D) spectroscopy. The algorithms are first tested on model data, showing that both are able to reconstruct the spectra using only a fraction of the data required by the traditional Fourier-based estimator. Through the analys
Critical infrastructures provide essential services for the functioning of the society, and vulnerability analysis is an important basis for decisions concerning increasing their robustness against strains. Since critical infrastructures can be regarded as complex systems, such analyses can prove challenging. To analyze the system response to strains, several different functional models have been
The impact of systemic 27-hydroxycholesterol (27HC) and intratumoral CYP27A1 expression on pathobiology and clinical response to statins in breast cancer needs clarification. 27HC is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27HC also acts as an endogenous selective estrogen receptor (ER) modulator capable of increas
Since I finished my PhD thesis in June 2014, I have lived a stimulating but also somewhat precarious life at Lund University. It is no secret that permanent teaching positions are hard to come by, and during the time I have been teaching as temporary staff on a number of different courses, I have started to consider what the lack of permanent positions means for the pedagogical work carried out at
There is an increasing consensus that individual adaptive capacities are critical to successfully adapt to climate change and achieve sustainable development. However, little is known about adaptive practices, particularly in developed countries. Against this background, this paper investigates the strategies used by Swedish citizens to adapt to (changing) climatic variability and extremes. It off
Popular Abstract in Swedish I Sverige har andelen förtidspensionärer ökat under lång tid och uppgick år 1998 till 7.6% av befolkningen i arbetsför ålder (16-64 år). Den vanligaste orsaken till att en individ förtidspensioneras är reducerad arbetsförmåga till följd av problem i rörelseorganen. Kunskaperna om förtidspensionärers livskvalitet är bristfälliga. Syftet med denna studie var att studera lThe starting-point of this thesis was the high rate of disability pensioners in Sweden and the lack of knowledge about what a disability pension entails for quality of life (QL). The aim of the study was to gain knowledge about QL among disability retirees with musculoskeletal disorders (ERPs). A questionnaire was sent in 1992 to 450 ERPs in Kristianstad Municipality, Sweden, granted their disabil
Critical infrastructures provide indispensable services to society and extensive disruption of these give rise to large societal consequences. Most risk-related studies of critical infrastructures, however, focus rather narrowly on the direct consequences, e.g. expressed by services not supplied or cost of nonsupplied services. Although these measures might serve as a proxy for the direct societal
To study cortical re-organisation after acute hand deafferentation, we investigated 10 experimental subjects and 10 controls for function in the left hand, before, during and after tourniquet induced anaesthesia of the right hand. fMRI was performed in three experimental subjects. Tourniquet-induced right hand anaesthesia resulted in rapid significant improvement in grip strength, tactile discrimi
Increasing interdependencies between critical infrastructures have made these systems more effective, but also more susceptible to cascading failures. In order to reduce the likelihood and consequences of cascading failures, it is essential to develop tools that support incident commander decisions so that an initial failure does not spread to other infrastructures. Here, a framework for generatin
