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Purpose: In one form of human autosomal recessive retinitis pigmentosa and in retinal degeneration (rd1) mouse, mutation occurs in the genes encoding ß subunit of rod photoreceptor cGMP phosphodiesterase. Therefore, rd1 mutant mouse is an appropriate model for human inherited retinal degeneration studies. Retinal explants are successfully cultured in serum free chemically defined R16 medium to eva

Popular Abstract in SwedishDenna avhandling handlar om kvinnor i missbrukarbehandling och deras beskrivningar av sig själva som kvinnor, den s.k. femininitetsprocessen. Syftet är att beskriva och försöka förstå behandlingens betydelse i kvinnornas femininitetsprocesser och vilken innebörd rusmedel, män, den egna kroppen, moderskap och sexualitet har och har haft däri. Avhandlingen har huvudsakligeThis thesis is about women in drug abuse treatment and their descriptions of themselves as women - their process of becoming feminine. The aim of the thesis is describing and trying to understand the meaning of the treatment in the women's femininity processes and what significance drugs, alcohol, men, the own body, motherhood, and sexuality have and have had in the process. The emphasis is on the

Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting

Background The purpose of these studies was to compare efficacy and toxicity of docetaxel alone with the combination of gemcitabine and docetaxel for treatment of metastatic esophageal carcinoma. Patients and methods These studies enrolled patients with histopathologically verified squamous cell carcinoma or adenocarcinoma of the esophagus or cardia. Between March 1997 and June 1999, 52 patients w

This study analyzes the relationship between drought processes and crop yields in Moldova, together with the effects of possible future climate change on crops. The severity of drought is analyzed over time in Moldova using the Standard Precipitation Index, the Standardized Precipitation Evapotranspiration Index, and their relationship with crop yields. In addition, rainfall variability and its re

OBJECTIVES: The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioi

Climate change and land-use change represent a dual threat to terrestrial ecosystem functioning. In the tropics, forest conversion to agriculture is occurring alongside warming and more pronounced periods of drought. Rainfall after drought induces enormous dynamics in microbial growth (potential soil carbon storage) and respiration (determining carbon loss), affecting the ecosystem carbon budget.

This study is aimed at detecting Parkinson's disease by analyzing voice measurements made using a mobile phone. The key objectives include creating a model that ensures accurate predictions while maintaining interpretability, consistent with the existing literature on Parkinson's disease. We introduce a novel group-wise scaling method to address typical age and biological sex biases in the dataset

Background: Eating disorders significantly impact physical health and have negative psychosocial consequences. The global burden of anorexia nervosa and bulimia nervosa among young females is estimated to account for 1.9 million disability-adjusted life years. Early identification of disordered eating attitudes is critical for preventing the progression to more severe forms of eating disorders; ho

Given the important role of the land surface for climate, this study aims at (1) to evaluate the quality of the simulation of surface climate by the land-surface component of the EC-Earth3 ESM and (2) to assess the role of the coupling of the land surface with the atmosphere for the simulation of the surface climate in EC-Earth3. It is based on three simulations with different configurations of th

In this paper, we consider real-time modelling of an underwater acoustic channel impulse response (CIR), exploiting the inherent structure and sparsity of such channels. Building on the recent development to model acoustic channels using a Kronecker structure, we propose a sparse block updating conjugate gradient algorithm. The method initially compensate for the drift common in underwater measure

Environmental changes and their effects are among the most pressing topics of today's ecological research. Shrublands, although widespread across the globe, remain understudied in this respect. We conducted a global meta-analysis of 81 shrubland sites subjected to experimental warming, shifts in precipitation (e.g. increased precipitation and drought), and nitrogen addition to quantify seven types

Human pose forecasting is the task of predicting articulated human motion given past human motion. There exists a number of popular benchmarks that evaluate an array of different models performing human pose forecasting. These benchmarks do not reflect that a human interacting system, such as a delivery robot, observes and plans for the motion of the same individual over an extended period of time

Vowel-based voice analysis is gaining attention as a potential non-invasive tool for COPD classification, offering insights into phonatory function. The growing need for voice data has necessitated the adoption of various techniques, including segmentation, to augment existing datasets for training comprehensive Machine Learning (ML) modelsThis study aims to investigate the possible effects of seg

Avoiding severe global warming requires large-scale removals of atmospheric carbon dioxide. Forest regeneration offers cost-effective carbon removals, but annual rates vary substantially by location and forest age. Here we generate grid-level (~1-km2) growth curves for aboveground live carbon in naturally regrowing forests by combining 109,708 field estimates with 66 environmental covariates. Acro

Quantifying the spatial and temporal patterns of drought characteristics is crucial, given the increasing frequency and intensity of drought events over the past 20 years in China. However, the patterns of drought frequency and duration in different regions and their differences remain unclear. Traditional indices for detecting and quantifying droughts, such as the Standardized Precipitation Evapo

Background: Several studies have investigated the association between metabolic syndrome (MetS) and physical activity (PA). However, further research is needed using objective measures of PA in free-living conditions, while also accounting for the time-variant nature of MetS. This study aimed to: (1) investigate the association between wearable device-measured step count and 5-year MetS incidence

Time-frequency (TF) postprocessing methods are often used to form concentrated TF representations (TFRs) for nonstationary signals. Regrettably, most such techniques are sensitive to noise and tend to underestimate weak components when dealing with transient signals, resulting in sidelobes and low-resolution TFRs. In this work, we introduce a generalized group delay (GD) weighted sparse TF (GWSTF)

Aim: This study investigated how human activities and local environmental variables shape tree assemblages (species composition in a defined location), comparing their effects on edible and inedible tree species. Three hypotheses were tested: (1) Environmental filtering impacts spatial beta-diversity more than dispersal limitation; (2) human activities significantly influence regional tree beta-di

Background: Chronic obstructive pulmonary disease (COPD) is a severe condition affecting millions worldwide, leading to numerous annual deaths. The absence of significant symptoms in its early stages promotes high underdiagnosis rates for the affected people. Besides pulmonary function failure, another harmful problem of COPD is the systemic effects, e.g., heart failure or voice distortion. Howeve