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Large control signal derivatives or inter-sample differences may harm actuators. An optimization constraint limiting such variations, related to measurement noise, is derived. Using the constraint, optimal PI, PID and measurement filters with different orders are designed for several processes and compared to the optimal linear controller of high order found via Youla parametrization. Simulations
Membrane proteins are important building blocks for several biochemical processes. The difficulty with membrane proteins is that they tend to be lowly expressed and can be difficult to manage. Therefore, membrane proteins are studied to a lesser extent than soluble proteins. Since membrane proteins are intrinsically hydrophobic, their purification and structural determination critically rely on so
MicroProteins are small, separately expressed parts of a larger protein and able to interfere with the full-length protein’s function. To enable modulation of hormone perception, microProteins were designed from the ethylene, cytokinin and gibberellin receptors. The protein isoforms designed to function as microProteins were overexpressed in Arabidopsis. Overexpression of a shortened gibberellin r
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/
In the morning hours of April 11, the Natanz nuclear facility in Iran was attacked, allegedly by Israel. The strike came at a sensitive time, as Iran and world powers are discussing Washington’s return to the Joint Comprehensive Plan of Action (JCPOA) and the removal of sanctions. According to Israeli estimates, as the Islamic Republic does not wish to jeopardize a US return to the JCPOA, its resp
Exposure to air pollution is associated with adverse health effects in humans, with special concern for exposure to fine particulate matter (PM2.5). The physicochemical properties of aerosols impact the health effects. Considering that we spend approximately 90% of our time indoors, it is important to gain increased understanding of indoor aerosol concentrations and properties. The overall aim of
Liquid chromatography-mass spectrometry (LC-MS) and mass spectrometry imaging (MSI) are two techniques that are routinely used to study proteins, peptides, and metabolites at a large scale. Thousands of biological compounds can be identified and quantified in a single experiment with LC-MS, but many studies fail to convert this data to a better understanding of disease biology. One of the primary
The use of 3D city models is changing from visualization to complex use cases where they act as 3D base maps. This requires links to registers and continuous updating of the city models. Still, most models never change or are recreated instead of updated. This study identifies obstacles to version management of 3D city models and proposes recommendations to overcome them, with a main focus on the
Experimental microbial ecology and evolution have yielded foundational insights into ecological and evolutionary processes using simple microcosm setups and phenotypic assays with one- or two-species model systems. The fields are now increasingly incorporating more complex systems and exploration of the molecular basis of observations. For this purpose, simplified, manageable and well-defined mult
The reassignment technique is used to increase localization for signal components in the time-frequency representation. The technique gives perfect localization for linear chirp signals and constant frequency signals. Despite the recent interest in using the reassignment technique to determine phase-shifts, no general expression of cross-spectrogram reassignment vectors exists. This submission aim
When individuals self-select (or are selected) into a study based on factors that influence the outcome, conclusions may not generalize to the full population. To compensate for this, results may be adjusted, for example, by standardization on the set of common causes of participation and outcome. Although such standardization is useful in some contexts, the common causes of participation and outc
A method for generating motion-corrected medical images includes obtaining, via a processor, k-space data of a region of interest acquired by a magnetic resonance imaging system utilizing a 3D radial pulse sequence with ZTE acquisition including optional magnetization preparation pulses. The method also includes sampling, via the processor, the k-space data to obtain a plurality of interleaved k-s
Medical research generates a large number of publications with the PubMed database already containing >35 million research articles. Integration of the knowledge scattered across this large body of literature could provide key insights into physiological mechanisms and disease processes leading to novel medical interventions. However, it is a great challenge for researchers to utilize this informa
The lung is a vital and dynamic organ that serves as a critical first barrier to environmental stimuli and facilitates gas exchange from birth until death. Developmental or genetic defects that impair lung function severely impact quality of life. Minor defects present in early life increase the likelihood that patients will develop chronic lung diseases in adulthood that have no cure. Current the
The building sector is responsible for more than 40% of the energy use and 32% of carbon dioxide emissions in the European Union (EU). Previous research has shown that the present rate of energy retrofit and refurbishment in Europe is far below (< 50%) than that is required to meet the EU’s building related energy efficiency goals for 2020.Appropriate policy interventions for deep renovation is pe
This is the final deliverable of WP6, the training and capacity building work package of ENVRI-FAIR. The objectives of WP6 were to provide training to ENVRIs and key ENVRI stakeholder groups about the FAIR principles, how to implement these in practice in RI services and data management activities at data centre level, how to evaluate the degree of implementation using FAIR metrics, as well as rel
