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Background: OncoMasTR is a new multigene prognostic test that was discovered via a novel transcriptional network analysis method that identified upstream Master Transcription Regulators (MTRs), which regulate previously identified prognostic biomarkers. The optimised OncoMasTR signature incorporating clinicopathological information has been shown to be significantly prognostic for predicting dista
Arktiska miljöer har de senaste decennierna upplevt en stark temperaturökning, vilket påverkar tundrans kolcykel.Smältande permafrost, minskande snötäcke och förändringar i hydrologiska mönster är exempel på pågående processer som förändrar samspelet mellan mark och atmosfär samt ekosystemens säsongsdynamik.Då ett antal av dessa processer involverar utbyte av växthusgaser, såsom spårgaserna metan Arctic environments have experienced strong warming in recent decades, which is affecting the carbon cycle of tundra ecosystems.Degrading permafrost, diminishing snow cover, and changing hydrology are examples of ongoing processes that affect the land-atmosphere interactions and seasonal ecosystem dynamics.Since a number of the affected processes involve the exchange of atmospheric greenhouse gase
Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region. We have developed an encapsulated cell technology that overcomes these obstacles by providing a targeted, continuous, de novo synthesized source of high levels of neurotrophic mole
Många processer i naturen går inte att förklara utan att gå ner på den molekylära skalan och studera enstaka laddningar som elektroner.Till exempel är laddningars rörelse i molekyler en viktig aspekt i fenomen som blixtar och norrsken. Ofta kan dessa processer bara uppstår när sammansättningen av atomer eller molekyler är på ett specifikt sätt; på samma vis som två hjul och en ram behöver sitta ihThe origin of properties in complex systems can often be traced to mechanisms involving charge and energy transfer in only a few embedded molecules. The detailed study of the time evolution of these mechanisms in their original environment is a challenging task. In this thesis we develop experimental tools and methods to enable the study of charge and energy transfer. A new ion and electron moment
This chapter examines the human search, understanding, and interpretation of biosignatures. It deals with four epistemological issues in the search for signs of life in outer space: (1) conceptualization, how we form concepts of life in astrobiology, how we define and categorize things, and the relation between our concepts and our knowledge of the world; (2) analogy, how we see similarities betwe
BACKGROUND: Little is known regarding sperm production following adjuvant treatment in testicular cancer (TC) clinical stage I (CS I) patients. PATIENTS AND METHODS: A total of 182 TC patients aged 18-50 years were prospectively included during 2001-2006 at any given time within 5 years of orchiectomy. Semen samples were delivered postorchiectomy but before further treatment, 6, 12, 24, 36 and 60
Secondary lymphedema (LE) following breast cancer-related surgery is a life-long complication, which currently has no cure. LE induces significant regional adipose tissue deposition, requiring liposuction as a treatment. Here, we aimed to elucidate the transcriptional, metabolomic, and lipidomic signature of the adipose tissue developed due to the surgery-induced LE in short- and long-term LE pati
Fetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systemati
Based on repeated surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southern-most Sweden, and analyses based on species-specific traits and ecological indicator values, it is concluded that significant changes have taken place 2018–2020 but that they probably mostly reflect the effects of the extremely dry and hot summer of 2018. Species richness has increased signBased on repeated surveys of the vascular plant flora in 120 hectar plots in the province of Scania, southern-most Sweden, and analyses based on species-specific traits and ecological indicator values, it is concluded that significant changes have taken place 2018–2020 but that they probably mostly reflect the effects of the extremely dry and hot summer of 2018. Species richness has increased sign
Elevated levels of neutrophil extracellular traps (NETs) have been reported in primary graft dysfunction, making methods to reduce or remove them highly valuable. The mechanisms behind primary graft dysfunction remain rudimentarily understood but its relation to higher rates of acute and chronic rejection necessitates the development of preventative treatments. This case series explores the use of
This study investigates the use of journey mapping as a tool for visualizing theflow of information in home care. Journey mapping is a design method with the purpose of visualizing the interaction of a user and a product or service. It tries to encompass the whole user experience including actions and touch points between user and product, feelings and other related information. Hence, the visuali
This thesis explores the anti-media populist discourse of the current Slovak Prime Minister Robert Fico, with which he harshly targets Slovak mainstream media to delegitimize them and their critical reporting. This practice, which Fico has been engaging in for many years, was originally considered problematic mainly due to its potentially detrimental consequences for trust in the media among many
The aim of this study was to describe and analyze the criminal gang members' experiences of the exit process. What we mean by the exit process is the way in and out of gang crime and the maintenance of the new role of non- criminal gangs.We have, through qualitative semi-structured interviews interviewed former criminal gang members and analyzed their experiences using Ebaughs (1988) theory ab
The Kyoto Protocol was adopted in 1997 as a way to combat greenhouse gas emissions and climate change. The Kyoto Protocol contains three flexible mechanisms that will help the parties achieve their emission targets cost effectively. One of the flexible mechanisms – the Clean Development Mechanism (CDM) – is further investigated and evaluated in this essay. Through the CDM the developed countries p
The present work details a study of the 3D-modeling of dual-fuel engines, with a specific focus on medium speed marine engines. These operate under the fumigated approach, which means that the second fuel, which replaces most of the diesel fuel, is added in the intake duct. This type of engine requires the least amount of modifications to the current medium speed diesel engine and is therefore an
The purpose of this thesis is to investigate how Swedish female foodies practice their food hobby while living in rural areas. A qualitative study was conducted with an inductive approach, using food diaries and semi-structured in depth interviews. This study is part of a larger Foodie research study conducted by Sofia Ulver. Our theoretical perspective has its starting point in Consumer Culture
The background for this master thesis is the stricter emission control requirement in heavyduty diesel engines at the same time as the demands for improved diesel engine efficiency are getting stronger. One approach to meet these demands is to increase the fuel injector pressure. A higher fuel injector pressure makes the fuel spray more finely dispersed into the cylinder and a better combustion is
The computerization of government transactions results in dramatic increase in growth of data across government agencies. This data is presented, generated, maintained and used independently in each government department and agencies which leads to poor decisions and isolated planning. This environment hinders effective access to data, reuse and aggregation, so that decision makers can get useful
This master thesis was performed at Lund Institute of Technology and Dresser Wayne Pignone, Malmö. It aims to achieve two new design concepts for fuel dispensers, which is Dresser Wayne’s main business area. The dispenser, Global Star, which was to be redesigned is a C-style model and should remain so, i.e. have the hoses located on one side of the hydraulic cabinet. This cabinet fits the hydrauli
