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The objective was to study ambulatory blood pressure and heart rate variability between day and night in patients with type 1 (insulin-dependent) diabetes mellitus with different degrees of diabetic nephropathy, and to evaluate the influence of autonomic neuropathy and type of antihypertensive treatment. Twenty type 1 diabetic patients with diabetic nephropathy and antihypertensive treatment were
The focus of this thesis is exception handling in recipe-based batch control. Exception handling is a critical element for achieving long-term success in batch production. It is reported to constitute 40-60 percent of the batch control design and implementation effort. Correct handling of exceptions is a key element in process safety, consistent product quality, and production cost minimization. T
The aims of this study were to describe which self-care, productivity, and leisure occupations individuals with multiple sclerosis (MS) perceive as difficult to perform on admission to rehabilitation and the individuals' own perception of the importance of, performance of, and satisfaction with these occupations. Whether the reported self-care, productivity, and leisure occupations were related to
OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive gra
Resistance to the HER-2 targeting drug trastuzumab can be observed clinically, but the lack of suitable experimental models hampers studies of resistance mechanisms. We characterized a HER-2–positive carcinoma cell line (JIMT-1) derived from a 62-year-old breast cancer patient which was clinically resistant to trastuzumab. Multicolor fluorescence in situ hybridization revealed a complex hyperdiplo
Andelen äldre vuxna växer stadigt världen över. År 2030 beräknas en av sex personer i världen att vara 60 år eller äldre. Denna demografiska förändring innebär stora utmaningar för många länder. Bland annat att säkerställa att dagens snabbt växande tekniska utveckling tillgodoser behoven hos äldre vuxna. Flygindustrin är en av de industrier där det går att se en ökning av äldre vuxna bland passageThe demographic group of older adults is growing significantly worldwide. It is predicted that by 2030, one in six people in the world will be aged 60 years or older. This demographic shift presents major challenges for many countries to ensure that the fast-growing technology developments are ready to fulfil the needs of older adults. The flight industry is one of the industries that experience a
As the industrial, commercial, and domestic prevalence of Internet of Things networks grows, so does the search for viable solutions to decrease their energy consumption. One common solution is using a low-power proxy that can control the power state of the devices within the network. To evaluate such solutions, either implementations can be made and measured for energy consumption, or energy mode
With unrest prominent in the entire world, cybersecurity is more important than ever before. With this, the need for education and strengthening practices within critical infrastructure and organisations is growing. This master’s thesis is done in collaboration with the Swedish Defense Research Agency (FOI) and aims to create a new Graphical User Interface (GUI) for their cybersecurity tool Scanni
Saccharomyces cerevisiae has emerged as a versatile platform for whole-cell biocatalysis, owing to its intrinsic regeneration of cofactors and amenability to genetic engineering. However, efficient reductive amination of aromatic carbonyls remains challenging due to competing redox pathways and product inhibition by pyruvate. Building on the redox-rewired TMB4133 strain (∆gpd1,2) that accumulates
Pollinators are essential for biodiversity and ecosystem services but face growing threats from climate change. Microclimates may buffer these impacts by providing localized climatic refugia. I assessed community-level and body size-dependent responses of bees, butterflies, and hoverflies to microclimatic temperature, humidity, wind, and structural shelter in semi-natural grasslands in southern Sw
This master’s thesis maps and compares local literary networks within UNESCO’s Cities of Literature, with the aim of understanding how such networks are structured, what their functions are and how they are controlled and developed. Drawing on concepts from social network analysis and Bourdieu’s theories of social fields, capital and habitus, the study combines quantitative and qualitative methods
As Climate Change increases the frequency and severity of wildfires in British Columbia, communities at the Wildland Urban Interface face escalating risks. This thesis explores the challenges and opportunities of community engagement in wildfire management in the city of Kamloops, one of the most fire-prone urban areas in British Columbia. Employing a single-case study design, the research is base
Smart grids are widely promoted as efficient, low-carbon solutions for energy transitions, yet their governance often treats digital infrastructure as immaterial and uniformly beneficial. This obscures the material, temporal, and justice dimensions that shape real-world outcomes. We introduce Circular Grid Governance (CGG), a framework that integrates circular-economy principles, lifecycle thinkin
INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
Both high-mountain rivers and wet-based mountain glaciers are considered effective erosion agents. They acted alternatively or simultaneously during the late Quaternary in the Tatra Mountains (West Carpathians) thus producing a vast amount of clastic material that was subject to deposition, reworking and transportation downstream. A small fraction of that amount of the material is still preserved
Machado-Joseph disease (MJD/SCA3) is the most frequent dominant ataxia worldwide. It is caused by a (CAG)n expansion. MJD has two major ancestral backgrounds: the Machado lineage, found mainly in Portuguese families; and the Joseph lineage, present in all five continents, probably originating in Asia. MJD has been described in a few African and African-American families, but here we report the fir
Objective: The aim was to investigate associations between dental healthcare utilization and all-cause, cardiovascular (CVD), cancer, and other-cause mortality. Materials and methods: A postal public health survey was distributed in the autumn of 2008 to a strat-ified random sample of the population aged 18–80 in Scania, southern Sweden (response rate 54.1%). Baseline survey data were linked to mo
