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Apotosis is an essential process tightly regulated by the Bcl-2 protein family where proapoptotic Bax triggers cell death by perforating the mitochondrial outer membrane. Although intensively studied, the molecular mechanism by which these proteins create apoptotic pores remains elusive. Here, we show that Bax creates pores by extracting lipids from outer mitochondrial membrane mimics by formation
Background: European treatment guidelines recommend prasugrel over ticagrelor for treating patients with non–ST-elevation acute coronary syndrome (ACS), prompting several Swedish administrative regions to transition from ticagrelor to prasugrel as the preferred treatment for patients with ACS. We aim to systematically evaluate this transition to determine the relative efficacy of prasugrel versus
Background and aim: Although recommended, the P-score used for assessing the pertinence / relevance of findings seen in small bowel (SB) capsule endoscopy (CE) is based on a low level of knowledge. The aim of this study was to evaluate the clinical relevance of the most frequent SBCE findings through an illustrated script questionnaire. Materials and Methods: Sixteen types of SBCE findings were il
PURPOSE: To investigate estimated delivered dose distributions using weekly cone-beam computed tomography (CBCT) scans for pelvic organs at risk (OARs) in salvage radiotherapy (SRT) after radical prostatectomy. Furthermore, to compare them with the originally planned dose distributions and analyse associations with gastrointestinal (GI) and genitourinary (GU) side effects.METHODS: This study is pa
Background: Lignosulfonates are significant wood chemicals with a $700 million market, produced by sulfite pulping of wood. During the pulping process, spent sulfite liquor (SSL) is generated, which in addition to lignosulfonates contains hemicellulose-derived sugars—in case of hardwoods primarily the pentose sugar xylose. The pentoses are currently underutilized. If they could be converted into v
A search is presented for the pair production of higgsinos χ˜ in gauge-mediated supersymmetry models, where the lightest neutralinos χ˜1 0 decay into a light gravitino G˜ in association with either a Higgs h or a Z boson. The search is performed with the ATLAS detector at the Large Hadron Collider using 139 fb−1 of proton–proton collisions at a centre-of-mass energy of s=13
Half of parents to infants and toddlers experience unwanted intrusive thoughts (UITs) about intentionally harming their child. For some, this can lead to impaired parental self-efficacy, elevated parental stress, and symptoms of depression. Many do not disclose their thoughts due to shame. Our research group has developed a self-guided online cognitive intervention for parents with distressing UIT
Layered TiS2 has been proposed as a versatile host material for various battery chemistries. Nevertheless, its compatibility with aqueous electrolytes has not been thoroughly understood. Herein, we report on a reversible hydration process to account for the electrochemical activity and structural evolution of TiS2 in a relatively dilute electrolyte for sustainable aqueous Li-ion batteries. Solvate
OBJECTIVE: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines.RESEARCH DESIGN AND METHODS: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes
Key performance indexes (KPIs) in various forms have always been used in one way or another in the production and processing of raw materials. The need for KPIs was accentuated with the advent of industrialism in the western world. The way and strategy of manufacturing industrial products has been divided into several so-called developmental transformations. Primarily after the depression of the 1
There is a need for more efficient measures to ensure responsible migration in host countries. Sports are recognised as a key measure to promote integration. This thesis’s purpose is to increase the understanding of the impacts football clubs have on integration for youth girls with foreign backgrounds in Stockholm, Sweden. This is done by exploring social relations’ role in integration and examin
Despite progress over the last decades, East Africa has one of the highest ratios of preventable maternal mortality in the world. This qualitative case study sheds light on Midwife-Led Care (MLC) in Ethiopia, Kenya, Malawi and Somalia. MLC is a model of care associated with improved health outcomes and enhanced utilization of health systems resources. Nevertheless, the model is not properly integr
Objectives: Multi-stakeholder partnership is garnering greater attention worldwide as a means of tackling global wicked problems, implementing sustainable development and leveraging development cooperation. By adopting meta-governance approach, this study investigates the case study of Hoi An - A Green Destination partnership in the waste management context of Hoi An city, Vietnam to understand ho
Denna uppsats syftar till att undersöka hur EU-rätten har påverkat svenska arbetstagarorganisationers möjligheter att använda sig utav stridsåtgärder och vilka effekter denna påverkan kan ha på den svenska arbetsmarknadsmodellen. För det första måste det sägas att EU-domstolens genom Laval och Viking har gjort det svårare för arbetstagarorganisationer att vidta stridsåtgärder då domstolen ansett aThis thesis has the aim of investigating how EU-law has affected the legal position regarding Swedish trade union’s possibilities of undertaking industrial actions. It also aims at determining whether the influence of EU-law on the right to undertake industrial actions has had any effects on the Swedish model. According to CJEU’s judgements in Laval and Viking it must be said that the possibilit
Som en del av innovationsarbetet och tillväxten inom Axis, har rörelsedetektering med hjälp av ny teknik utforskats. Genom sin utveckling har, bilindustrin sänkt kostnaderna på RAdio Detection And Ranging (RADAR) sensorer, vilket gör dem till en attraktiv hårdvara att inkludera i övervakningskameror och dess system. Men, hur kan den nya hårdvaran förbättra övervakning och ge slutanvändaren en bättAs a part of the innovation and growth within the Axis, object detection with new technology is explored. The car industry is lowering the costs on RAdio Detection And Ranging (RADAR) chipsets, making them a viable hardware to incorporate within a surveillance camera device. How can the new hardware improve surveillance and provide the end user with an enhanced experience? One challenge is to grap
