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Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. In this work, we mainly studied the in vitro Abet
Looking into the topic of cloud sourcing, at first glance it might be seen as an off the shelf pay per use service that is easy and fast to adopt for most companies. Although in practice not all companies succeed with cloud sourcing. Previous research shows that cloud sourcing entails risks especially in the adoption phase in terms of security, trust, data loss, and transparency among others. The
Background and problem: In October 2010 the European Commission issued a Green Paper on Audit Policy in which they set out to draw lessons of the auditors’ role in the recent financial crisis. The European Commission considers the function of the audit to be a key contributor to investor confidence and suggests a number of controversial measures with the aim of ensuring financial stability in the
This article discusses problems concerning the use of colour in botanical illustrations, focusing on a specific species, the Orchis ustulata (Burnt Orchid). In 1901-1905 the Swedish botanist Carl Lindman (1856-1928) was responsible for the publication of the Swedish flora Bilder ur Nordens flora, that was, in some ways, a reworking of J. W. Palmstruch’s Svensk botanik (1802-1843). Palmstruch’s han
Until recently studies regarding the pathological aspects of refugee experiences have led the psychology field of forced migration, giving little space to positive factors like the resilience and well-being of individuals faced with these adversities. This doctoral thesis emphasizes good health rather than disease and aims at deepening the understanding of resilience and health as opposed to the d
Background: Shiga toxin producing Escherichia coli (STEC) inducing hemolytic uremic syndrome (HUS) with multiple organ involvement is associated with significant morbidity and mortality. The treatment has mostly been focused on kidney, respiratory and cardiovascular supports and not against the bacteria that cause STEC-HUS. The use of bactericidal therapy has been shown to be antibiotic dependent
Operation med konstgjorda ledproteser i höft och knä ger generellt mycket lyckade resultat. Fortfarande förekommer dock lossning och slitage av komponenterna som ett problem, och alla patienter blir inte fullt nöjda. I ett flertal forskningsprojekt studerar vi faktorer av betydelse för fixation och funktion av proteskomponenterna. Vi utvärderar hur man optimerar de biomekaniska ledförhållandena viTotal joint replacements, both in the hip and knee, are generally very successful operations. Still, however, component loosening as well as wear remains a problem, and all patients are not fully satisfied with their new joint. In a number of ongoing investigations, we are studying different factors involved in the fixation and function of the prosthesis components. We are exploring how to optimiz
