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Background Endotoxin induces an inflammatory response, with secondary release of cytokines, which can progress to shock and multiple organ failure. We explored whether continuous renal replacement therapy (CRRT) using a modified membrane (oXiris) capable of adsorption could reduce endotoxin and cytokine levels in septic patients. Methods Sixteen patients requiring CRRT for septic shock-associated
Background: Selecting high-quality habitat and the optimal time to reproduce can increase individual fitness and is a strong evolutionary factor shaping animal populations. However, few studies have investigated the interplay between land cover heterogeneity, limitation in food resources, individual quality and spatial variation in fitness parameters. Here, we explore how individuals of different
Intergrowths of baddeleyite have been found in zircon grain interiors from amphibolite- and granulite-facies felsic rocks from southwest Greenland. The zircon grains are either close to or in direct contact with quartz. A series of experiments has been conducted using natural, unaltered zircon grains ± SiO2 in H2O–CaCl2, and H2O–Ca(OH)2 solutions with varying molar proportions of Ca to Si at 900 °
A role for the Epstein-Barr virus in initiating Type 1 (insulin-dependent) diabetes mellitus has been proposed since Epstein-Barr virus BOLF1(497-513) AVTPL RIFIVP PAAEY has an 11 amino acid identity with HLA-DQw8 β (49-60) AVTPL GPPAAEY. Rabbit antisera to the BOLF1 (496-515) peptide crossreacted with the homologous DQw8 β (44-63) peptide but not with the related DQw7 β(44-63) peptide, which diff
The failure of pancreatic isletβ-cells is a major contributor to the etiology of type 2 diabetes.β-Cell dysfunction and declining β-cell mass are two mechanisms that contribute to this failure, although it is unclear whether they are molecularly linked. Here, we show that the cell cycle regulator, cyclin-dependent kinase 2 (CDK2), couples primary β-cell dysfunction to the progressive deterioration
The effects of an electron dense thiol reagent, Hg phenylazo ferritin, on β cell ultrastructure was studied in cell suspensions from mouse pancreatic islets. This type of thiol reagent induced severe damage in the β cells. The ferritin particles were traced with the electron microscope and found to be bound to the plasma membrane as well as to various cytoplasmic structures. The β cell cytotoxic a
AimsCan drug abuse (DA) be transmitted psychologically between adult siblings consistent with a social contagion model?MethodsWe followed Swedish sibling pairs born in 1932-1990 until one of them, sibling1 (S1), had a first DA registration. We then examined, using Cox regression, the hazard rate for a first registration for DA in sibling2 (S2) within 3 years of a first DA registration in S1 as a f
In this study, the influence of various air inlet angles on the heat transfer and flow friction characteristics of a 2-row plain finned oval tube heat exchanger is analyzed by experimental and numerical methods. The experimental results show that an air inlet angle 45° provides the best heat transfer performance, and an air inlet angle 90° provides the smallest pressure drop, while an air inlet an
Background: To assess the quality of life of people with dementia, measures are required for self-rating by the person with dementia, and for proxy rating by others. The Quality of Life in Alzheimer's Disease scale (QoL-AD) is available in two versions, QoL-AD-SR (self-rating) and QoL-AD-PR (proxy rating). The aim of our study was to analyse the inter-rater agreement between self- and proxy rating
In Italy, data and information on prevalence and characteristics of elder abuse are very limited, and a specific legal and policy framework is lacking. Some articles of the Penal Code refer to the larger context of violence against disadvantaged groups, and some general support services not specifically dedicated to this issue are managed by local municipalities. In this context, empirical researc
In this study, a three-dimensional, non-isothermal, two-phase flow mathematical model is developed and applied to investigate the effect of the GDL deformation on transport phenomena and performance of proton exchange membrane (PEM) fuel cells with interdigitated flow fields. The thickness and porosity of the GDL is decreased after compression, and the corresponding transport parameters (permeabil
Several studies have shown socioeconomic differences in leisure-time physical activity. One explanation may be socioeconomic differences in relevant psychosocial conditions. The Malmo Diet and Cancer Study is a prospective cohort study including inhabitants in Malmo, Sweden. The baseline questionnaire used in this cross-sectional study was completed by the 11,837 participants born 1926-1945 in 199
In their comment piece, Laycock and Lam (Environ. Res. Lett. 13 068001) focused on the importance for reducing emissions of actions beyond individual choices and overconsumption, and raise the issue of family planning as a human right. Here we respond that both individual and collective actions, in private and professional life, are important to reducing emissions to near zero in the next few deca
Background: Cerebral palsy (CP) is the most common cause of physical disability in childhood. A major challenge for delivering effective services for children with CP is the heterogeneity of the medical condition. Categorizing children into homogeneous groups based on functional profiles is expected to improve service planning. The aims of this study were to (1) to describe functional profiles of
Natural gas makes an increasing contribution to the European Union's energy supply. Due to its efficiency and low level of combustion emissions this reduces greenhouse gas emissions compared to the use of other fossil fuels. However, being itself a potent greenhouse gas, a high level of direct losses of natural gas in its process chain could neutralise these advantages. Which effect will finally p
OBJECTIVE: Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD.RESEARCH
METHODS: A cross-sectional analysis of the prospective EULAR Scleroderma Trial and Research database (EUSTAR) was performed. Patients fulfilling preliminary ACR 1980 classification criteria for SSc, with less than 3 years from the first non-Raynaud's symptom at first entry, were selected. A group of patients with less than 3 years from the first SSc symptom, including Raynaud's phenomenon, was als
INTRODUCTION: We have limited knowledge about the underlying disease mechanisms and causes of pain in hand osteoarthritis (OA). Consequently, no disease-modifying drug exists, and more knowledge about the pathogenesis of hand OA is needed, as well as a validation of different outcome measures. Our first aim of this study is to explore the validity of various imaging modalities for the assessment o
Understanding how environmental variation drives phenotypic diversification within species is a major objective in evolutionary biology. The seaweed fly Coelopa frigida provides an excellent model for the study of genetically driven phenotypes because it carries an α/β inversion polymorphism that affects body size. Coelopa frigida inhabits highly variable beds of decomposing seaweed on the coast i
