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Cerebral ischemia results in enhanced expression of smooth muscle cell endothelin and angiotensin receptors in cerebral arteries. We hypothesise that this phenomenon may be detrimental and that acute treatment with a combined non-hypotensive dose of the angiotensin AT, receptor inhibitor candesartan and the endothelin ETA receptor antagonist ZD 1611 reduces the infarct in experimental ischemic str

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Background and Aims Organisms may be polymorphic within natural populations, but often the significance and genetic background to such polymorphism is not known. To understand the colour polymorphism expressed in the diploid marsh-orchids Dactylorhiza incarnata, morphological, habitat and genetic differentiation was studied in mixed populations on the island of Gotland, supplemented with genetic m

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Background: Helicobacter pylori causes peptic ulcer disease and gastric cancer, and the oral cavity is likely to serve as a reservoir for this pathogen. We investigated the binding of H. pylori to the mucins covering the mucosal surfaces in the niches along the oral to gastric infection route and during gastric disease and modeled the outcome of these interactions. Materials and Methods: A panel o

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Background: To assess balance in single-limb stance, center of pressure movements can be registered by stabilometry with force platforms. This can be used for evaluation of injuries to the lower extremities. It is important to ensure that the assessment tools we use in the clinical setting and in research have minimal measurement error. Previous studies have shown that the ability to maintain stan

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The aim of this study has been to identify, explain and delineate praying among peasant communities in the ecclesiastical province of Uppsala, Sweden. Four aspects have been examined through the perspectives of ideals and practices, namely the standards of prayer, devotional prayer, prayer in times of need and prayer cultures. The standards of prayer considered the physical and mental behaviour of

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A kinetic investigation of the ammoxidation of toluene was carried out over a TiO,(B)-supported vanadium oxide catalyst with a loading corresponding to a theoretical monolayer. The partial pressures of reactants toluene, oxygen, and ammonia were varied, and rates were measured for the formations of benzaldehyde and benzonitrile. By analysis of the rate dependencies on partial pressures of reactant

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Popular Abstract in Swedish Bakgrund: Ischemisk hjärtsjukdom (IHS) och slaganfall är de främsta orsakerna till morbiditet och mortalitet i västvärlden och är ett stort hälsoproblem för samhället. Kardiovaskulära läkemedel används med syfte att förebygga (t. ex. blodtryckssänkande läkemedel och lipidsänkande läkemedel) eller lindra (t. ex. nitrater) dessa sjukdomar. Den optimala effektiviteten ("efBackground: Ischaemic heart disease (IHD) and stroke are the main causes of morbidity and mortality in developed countries and hence constitute a large public health problem. Cardiovascular drugs are used in an effort to prevent (e. g. blood pressure lowering drugs (BPLD) and lipid lowering drugs) and palliate (e. g. nitrates) these disorders. The efficacy and safety of these drugs have been evalu

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The purpose of this thesis is to characterize the health status of the population in early Lund. This is pursued by an osteological analysis of 3.305 individuals fron three time periods: c. 990-1100, c. 1100-1300 and c. 1300-1536. The individuals derives from cemeteries connected to four neighbouring churches, where one is the sucessor of the other (Trinitatis). One cemetery (Kattesund) is by and

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Proton Exchange Membrane (PEM) fuel cell systems have been studied as the alternatives of the internal combustion engine systems. However, these systems are not appearing in daily life yet, due to the high cost, shortage of infrastructure, technical issues, etc. Concerning technical issues, water/thermal management is a critical one to keep high proton conductivity in the electrolyte membrane for

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BACKGROUND: Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids from stored triacylglycerols. Its activity is regulated by reversible protein phosphorylation. In rat HSL Ser563, Ser659 and Ser660 have been shown to be phosphorylated by protein kinase A (PKA) in vitro as well as in vivo. METHODOLOGY/PRINCIPAL FINDINGS: In this study we employed site-directed mutagenesi

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The aim of this study was to investigate the prevalence of extended-spectrum beta-lactamase (ESBL)-producing bacteria in patients at various hospital wards and in a group of relatively healthy volunteers, in order to obtain greater knowledge on how common these bacterial strains are in hospital settings and in the general community. Participants (n = 427) were enrolled at a University Hospital and

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Popular Abstract in Swedish För material på nanoskalan har ytor och gränser större betydelse för materialets egenskaper än de har för storskaliga material. Detta beror på att yt/volymförhållandet är större för material på nanoskalan än för samma material på större skala. Ett fast material där atomerna sitter i en ordnad struktur eller gitter kallas för kristall. En kristall växer när ?nya? atomer Surfaces and interfaces have a special significance to nanotechnology because the surface/volume ratio of nanomaterials is larger than for bulk materials. Therefore, interfaces of nanomaterials are usually more important to the properties of nanomaterials than for larger scale materials. Furthermore, crystal growth occurs at the interfaces between the growing crystals and the supply media. An unde

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The influence of finite length gradient pulses on NMR diffusion experiments on liquids confined to diffuse between two parallel planes is investigated. It is experimentally verified that the pore size decreases when determined using finite gradient pulses if the results are analyzed within the short gradient pulse approximation. The results are analyzed using the matrix formulation. The observed m

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The composition of the colonic microflora is essential for the health of the human host. To be able to survive, the microflora is dependent of a continuous supply of substrate. In this respect dietary fibre and other indigestible carbohydrates, of which the consumption in affluent societies is generally low, are of great importance. Numerous of studies have demonstrated beneficial effects of dieta

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In order to meet the unprecedented challenge of feeding an increasing population while curbing associated environmental impacts a fundamental change in the current food system is required. Such a shift needs an active facilitator who could set and implement the sustainability agenda in the food supply chain. Recently, it has been argued that retailers might become a vital agent of change towards s

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Aims The glycosphingolipid sulfatide (sulfated galactosyl-ceramide) increases exocytosis of beta-cell secretory granules, activates K-ATP-channels and is thereby able to influence insulin secretion through its presence in the islets. A closely related compound, sulfated lactosylceramide (sulf-lac-cer), is present in the islets during fetal and neonatal life when, as in Type 2 diabetes, insulin is