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Noncoding variants at human chromosome 9p21 near CDKN2A and CDKN2B are associated with type 2 diabetes(1-4), myocardial infarction(5-7), aneurysm(8), vertical cup disc ratio(9) and at least five cancers(10-16). Here we compare approaches to more comprehensively assess genetic variation in the region. We carried out targeted sequencing at high coverage in 47 individuals and compared the results to
Kuannersuit Glacier, a valley glacier on Disko Island in west Greenland, experienced a major surge from 1995 to 1998 where the glacier advanced 10.5 km and produced a similar to 65 m thick stacked sequence of debris-rich basal ice and meteoric glacier ice. The aim of this study is to describe the tectonic evolution of large englacial thrusts and the processes of basal ice formation using a multipr
Background: Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotyp
Wood decay mechanisms in Agaricomycotina have been traditionally separated in two categories termed white and brown rot. Recently the accuracy of such a dichotomy has been questioned. Here, we present the genome sequences of the white-rot fungus Cylindrobasidium torrendii and the brown-rot fungus Fistulina hepatica both members of Agaricales, combining comparative genomics and wood decay experimen
Caterpillars of the mining micro-moth Phyllocnistis labyrinthella feed on leaves of aspen (Populus tremula) and are often parasitized by eulophid wasps. The parasitoids are a potential important cause of death for the miners. During 2009-2011 we collected mined leaves from an experimental stand of aspen trees in Västerbotten. Adults emerged from 17-35 percent of the mines and of these every second
Waldenstrom's macroglobulinemia (WM) is associated with a precursor condition, monoclonal gammopathy of undetermined significance (MGUS) of immunoglobulin-M (IgM) type. The etiology of these conditions is unknown. Recent studies at the population level have provided new data regarding familial aggregation of these disorders and other B-cell malignancies. Studies of familial clusters of WM have dem
Bakgrund: Psykisk ohälsa är idag ett växande problem hos unga vuxna och det finns behov av ytterligare interventioner. Fysisk aktivitet i grupp samt fysisk aktivitet på recept har enligt tidigare studier visat goda effekter på den upplevda hälsan. Inom arbetsterapin är aktivitetsvärde ett centralt begrepp som kan kopplas samman med meningsfullhet, hälsa och välbefinnande. Syfte: Syftet med studien
It is important to examine parent advocacy programs to understand how they function in a society where there are many structural obstacles to those with little power. These programs can provide an impactful way to level out power imbalances. This case study examined through a lens of legal consciousness theory, power and empowerment theory, and the four capitals as developed by Bourdieu, the pur
This study focus on influence of different drying and annealing conditions on the mechanical properties and film formation of the produced paint which is based on a novel hydroplasticized polymer dispersion. Two different coalescing agents with different polarity and a neat sample with two different thicknesses were used in order to study the influence of coalescing agent’s polarity, thickness and
Sylvia Plath’s The Bell Jar, Margaret Atwood’s The Edible Woman and Doris Lessing’s “To Room Nineteen” are three literary texts in which the three protagonists seem to play a role which makes them miserable and suicidal. This essay explores what elements that are involved in making these women unhappy and self-destructive. Based on a close reading of the three texts and Judith Butler’s theories on
Collapse of the Soviet Union and abolishment of the state atheism policy has led to an increase of Protestant organizations and their parishes in Ukraine. Some of them (at least fifteen) allow and practice women ordination. Women priests, thus, find themselves performing non-traditional gender roles in Ukraine, where the majority of the population is affiliated with Orthodox or Greek Catholic Chur
Geographical Information Systems are a powerful tool for the processing of geographical data and can be used to implement predictive modelling for the purpose of archaeological research. The study presented here proposes a predictive model based on multi-criteria evaluation, and aims at analysing the parameters of known Upper Palaeolithic decorated caves in the Périgord noir, in southwest France.
Cities around the world are not only facing the impacts of climate change but are also increasingly charged with the responsibility to adapt. The city of Malmö in Sweden, facing the consequences of ever-so-present pluvial floods, has set an objective to increase the use of multifunctional Nature-based Solutions (NBS) in its urban stormwater planning. Nevertheless, despite evidence pointing at the
Violation of Children´s Rights in the Area of Child Labour in Pakistan. Remedies Available under Domestic and International Law
Psychological research has in the last few decades moved away from viewing psychopathology as distinct categories towards a hierarchical, dimensional model where an empirically based structure reflects the similarities among disorders. New tools, such as the second version of The Inventory of Depression and Anxiety Symptoms (IDAS-II) have been developed to capture this dimensionality. In this time
Aim: The aim of this paper was to shed light on the different methods/strategies that Anti-Brand Communities (ABCs) use in order to cause harm to particular brands. Purpose: The purpose of this paper is to offer assistance to brand managers through Anti-Brand Community-insights, as a means of combating the increasingly growing number of ABCs. Research Question: What methods/strategies do anti-b
Allelopathy is a term first introduced by Hans Molisch in his 1937 book titled The Influence of One Plant on Another: Allelopathy and, as it stands, it is defined as the biological phenomenon through which growth, development, reproduction or survival of an organism are altered by the release of biochemicals from another. In this study, we investigate the allelochemical potential of leachates coll
Parkinson's disease (PD) is a neurodegenerative disease that is characterized by alpha-synuclein (α-syn) aggregations and loss of dopaminergic neurons. The cause for PD is still being researched but neuroinflammation has gained increasing awareness. Polymorphism in class II, major histocompatibility complex, transactivator (Ciita), which regulates major histocompatibility complex II (MHCII) ex
Background/introduction: E-commerce is becoming a natural part of retail business. In order to achieve a competitive edge, companies are shifting to omni channel retailing where channel integration is explored in the search for potential improvements in connection with customer offer and costs. One solution is to integrate inventories and offer improved order fulfilment by using both warehouse and
