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Estramustine phosphate (0.01 to 0.5 nriM), an estradiol mustard derivative used in the therapy of prostatic carcinoma, inhibited the assembly of brain microtubule proteins in vitro and disassembled preformed microtubules. In the presence of estramustine phosphate, the minimum microtubule-protein concentration sufficient for the assembly of microtubules was increased. Low concentrations of taxoi (2
Laser-induced incandescence (LII), elastic light scattering (ELS) and extinction were used to investigate the early stages of soot formation when seeding metal salts at various concentrations into a premixed ethylene/air flame on a PerkinElmer burner. The investigation contained seven salts, where we in this work mainly focus on two of these salts, potassium chloride (KCl) and iron chloride (FeCl3
This paper details and discusses work performed at the woodworking SME Mivelaz Techniques Bois SA within the SMErobotics FP7 project. The aim is to improve non-expert handling of the cell by introduction of cognitive abilities in the robot system. Three areas are considered; intuitive programming, process adaptation and system integration. Proposed cognitive components are described together with
The ion channel-forming peptide AlaM (alamethicin) is known to permeabilize isolated mitochondria as well as animal cells. When intact tobacco (Nicotiana tabacum L.) Bright Yellow-2 cells were treated with AlaM, the cells became permeable for low-molecular-mass molecules as shown by induced leakage of NAD(P)(+). After the addition of cofactors and substrates, activities of cytosolic as well as mit
The Chrysididae are a group of cleptoparasitic and parasitoid aculeate wasps with a large number of rare and endangered species. The taxonomy of this group has long been confusing due to the similarity of species and extensive intraspecific variation. We present for the first time a comprehensive dichotomous key for all 74 species found in the Nordic and Baltic countries. In addition to diagnostic
Pilgrimstad in central Sweden is an important locality for reconstructing environmental changes during the last glacial period (the Weichselian). Its central location has implications for the Scandinavian Ice Sheet as a whole. The site has been assigned an Early Weichselian age (marine isotope stage (MIS) 5 a/c; > 74 ka), based on pollen stratigraphic correlations with type sections in continental
The Tibetan highlands host the largest alpine grassland ecosystems worldwide, bearing soils that store substantial stocks of carbon (C) that are very sensitive to land use changes. This study focuses on the cycling of photoassimilated C within a Kobresia pygmaea pasture, the dominating ecosystems on the Tibetan highlands. We investigated short-term effects of grazing cessation and the role of the
Purpose: To estimate inter-observer agreement with regard to describing adnexal masses using the International Ovarian Tumor Analysis (IOTA) terminology and the risk of malignancy calculated using IOTA logistic regression models LR1 and LR2, and to elucidate what explained the largest inter-observer differences in calculated risk of malignancy. Experimental Design: 117 women with adnexal masses we
The majority of nitrogen in forest soils is found in organic matter-protein complexes. Ectomycorrhizal fungi (EMF) are thought to have a key role in decomposing and mobilizing nitrogen from such complexes. However, little is known about the mechanisms governing these processes, how they are regulated by the carbon in the host plant and the availability of more easily available forms of nitrogen so
Objectives: To describe change in functional ability in the oldest-old population during 3 years and examine its relation to life satisfaction (LS). A total of 681 individuals aged 78 and older from the population-based study Good Aging in Skane took part. Methods: Functional ability was assessed using Sonn and Asberg's Activities of Daily Living (ADL) scale and related to LS assessed by Neugarten
This paper presents a flexible architecture suitable for concurrent processing of multiple radio standards. The proposed architecture is based on a coarse-grained reconfigurable cell array, consisting of distinct processing and memory cells. Flexibility of the architecture is demonstrated by performing a coarse time synchronization and fractional frequency offset estimation for multiple OFDM stand
This paper presents measurements from the ATLAS experiment of the forward-backward asymmetry in the reaction pp -> Z/gamma* -> l(+)l(-), with l being electrons or muons, and the extraction of the effective weak mixing angle. The results are based on the full set of data collected in 2011 in pp collisions at the LHC at root s = 7 TeV, corresponding to an integrated luminosity of 4.8 fb(-1). The mea
This is Part 1 of an article arguing for an extended application of Karl Marx’s insight that the apparent reciprocity of free market exchange is to be understood as an ideology that obscures material processes of exploitation and accumulation. Rather than to confine this insight to the worker’s sale of his or her labor-power for wages, and basing it on the conviction that labor-power is uniquely c
This is Part 2 of an article arguing for an extended application of Karl Marx’s insight that the apparent reciprocity of free market exchange is to be understood as an ideology that obscures material processes of exploitation and accumulation. Rather than confine this insight to the worker’s sale of his or her labor-power for wages, and ground it in the conviction that labor-power is uniquely capa
Plants produce many bioactive, specialized metabolites to defend themselves when facing various stress situations. Their biosynthesis is directed by a tightly controlled regulatory circuit that is elicited by phytohormones such as jasmonate (JA). The basic helix-loop-helix (bHLH) transcription factors (TFs) bHLH iridoid synthesis 1 (BIS1) and Triterpene Saponin Activating Regulator (TSAR) 1 and 2,
Obesity and cigarette smoking are correlated through complex relationships. Common genetic causes may contribute to these correlations. In this study, we selected 241 loci potentially associated with body mass index (BMI) based on the Genetic Investigation of ANthropometric Traits (GIANT) consortium data and calculated a BMI genetic risk score (BMI-GRS) for 17,037 individuals of European descent f
INTRODUCTION: The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone mineral density (BMD), osteoporotic fractures and polymorphisms of TGFB1, although these studies have yielded conflicting results.METHODS: We investigated associations between TGFB1 polymorphisms and BMD a
The TCIRG1 gene encodes a component of the osteoclast vacuolar proton pump and previous work has shown that inactivating mutations of the TCIRG1 cause autosomal recessive osteopetrosis. In order to determine whether allelic variation in TCIRG1 contributes to the regulation of bone mineral density (BMD) in normal individuals, we studied the relationship between polymorphisms of TCIRG1 and BMD in a
BACKGROUND: Osteoporosis is a common disorder with a strong genetic component. One way in which the genetic component could be expressed is through polymorphism of COLIA1, the gene for collagen type Ialpha1, a bone-matrix protein.METHODS: We determined the COLIA1 genotypes SS, Ss, and ss in a population-based sample of 1778 postmenopausal women using a polymerase-chain-reaction-based assay. We the
