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Crosslinking of small heat-shock proteins (sHsps) by tissue transglutaminase (tTG) is enhanced by stress and under pathological conditions. We here used hexapeptide probes to determine the amine donor (K) and acceptor (Q) sites for tTG in Hsp20. Mass spectrometric peptide mass fingerprinting and peptide fragmentation established that Q(31) and the C-terminal K-162 are involved in inter- and intram

Popular Abstract in Swedish Två observationer tjänar som utgångspunkt för denna avhandling: (1) globaliseringens allt snabbare och mer eller mindre gränslösa flöde av information har medfört ökad press på företag och organisationer, liksom stater och regioner, att ständigt förnya sig för att kunna behålla sin konkurrenskraft. (2) kunskapsintensiv industri tenderar att samlas i geografisk närhet tiThe accelerated speed and intensity of global interconnections in all segments of society during the last couple of decades have had a profound impact on the workings of contemporary capitalism. Increased pressure is put on national and regional economies to continuously upgrade their competitive advantages, at the same time as new learning opportunities occur at a faster rate than ever. For reaso

As society today increasingly understands the impact of transnational corporate operations, an increasing recognition on the part of corporations of their responsibility for social and environmental well being of people in poor countries appears. The norm - Corporate Social Responsibility (CSR) grew out of such logic. The present study explores the extent to which CSR can be expected to contribute

With increasing age, human skeletal muscles gradually decrease in volume, mainly due to a reduced number of motor units and muscle fibers, and a reduced size of type 2 fibers. As a result, progressive weakening and impaired mobility occur. High-resistance strength training is beneficial, even in the very old, and could possibly reverse some of the detrimental effects of age-related weakness. The i

In this study of the transfer function of copies of the Vienna-type differential mobility analyser (DMA) it was found that three, supposedly identical, DMAs exhibited distinct differences with respect to the width of the transfer function. This means that the transfer function of a DMA needs to be determined on an individual basis in order to obtain accurate results from DMA measurements. The size

In many raptors and owls the male is the main provider of food in the early phase of the nestling period while the female incubates the eggs and broods the young. In the nestling period the female often helps the male to feed the young, but the factors affecting whether and when she leaves the brood to hunt have not been investigated in detail. We present a dynamic state variable model that analys

The BhMIR32 xyn11A gene, encoding an extracellular endoxylanase of potential interest in bio-bleaching applications, was amplified from Bacillus halodurans MIR32 genomic DNA. The protein encoded is an endo-1,4-beta-xylanase belonging to family 11 of glycosyl hydrolases. Its nucleotide sequence was analysed and the mature peptide was subcloned into pET22b(+) expression vector. The enzyme was over-e

Late Precambrian and Palaeozoic platform sediments from the Central-South Taimyr Peninsula (Arctic Siberia) are all remagnetised. The remagnetisation is prefold and is related to thermal remagnetisation caused by Taimyr Trap magmatism. The remagnetisation age is estimated to 220-230 Ma and, hence, is considerably younger than the ca. 251 Ma age for the main body of Siberian Trap flood basalts. The

Pollen analyses and AMS C-14 measurements were performed on lacustrine sediments and peat deposits from the former crater lake Steregoiu in a mid-altitude area in the Gutaiului Mountains in NW Romania in order to provide a detailed reconstruction of the vegetational development of the area during the Late-Glacial and Holocene. The bottom sediments are siliciclastic and were deposited probably duri

Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene expression. Furthermore, mitochondria play a role in different aspects of neurite outgrowth. Here we show that the expression of Ndufb11, a gene enco

Solid waste collection and hauling account for the greater part of the total cost in modern solid waste management systems. In a recent initiative, 3300 Swedish recycling containers have been fitted with level sensors and wireless communication equipment. thereby giving waste collection operators access to real-time information oil the status of each container. In this study. analytical modeling a

Using high-resolution synchrotron-radiation photoelectron spectroscopy and low-energy electron diffraction, we have studied the electronic and structural properties of the Yb-induced Ge(111)-(3x2) reconstruction with a 1/6 monolayer coverage. We found these properties to be similar in many respects to those of the metal-induced Si(111) and Ge(111) reconstructions described previously in terms of t

Serum-depleted human foetal skin fibroblasts were stimulated by addition of 10% foetal calf serum to proliferate synchronously for at least one cell cycle. This proliferation was suppressed by leukocyte or fibroblast interferon (IF), which prolonged the G1 phase and diminished the rate of DNA synthesis during the S phase in a dose-dependent manner. When used in identical concentration, as judged i