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Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the current study, we identified 62 high-confident PPT1-binding proteins. These proteins included a self-interaction of PPT1, two V-type ATPases, calcium volta
We present a discussion of the treatment of 1 Nc-corrections in chiral perturbation theory for nonleptonic weak processes. We compare the approach with an explicit cutoff and dimensional regularization in chiral perturbation theory and present evidence that they are equivalent. The quadratic dependence on the cutoff can be subtracted consistently at each level of 1 Nc. We discuss the identificatio
We investigated the intrinsic reactivity of CO on single-layer and multilayer PdO(101) grown on Pd(100) using temperature-programmed reaction spectroscopy (TPRS) and reflection absorption infrared spectroscopy (RAIRS) experiments, as well as density functional theory (DFT) calculations. We find that CO binds more strongly on multilayer than single-layer PdO(101) (∼119 kJ/mol vs 43 kJ/mol), and tha
We have simulated the 10-state 2d Potts model with the Metropolis and Swendsen-Wang algorithms, in order to compare their performances near a first-order phase transition. We show that a simple Markov model relates the frequencies of the flips between coexisting phases and the auto-correlation times. It leads to a coherent description of the dynamics. The ratio of the algorithm efficiencies has li
The decay from the 23+ state at about 2-MeV excitation in the nuclei Ba140, Ce142, and Nd144, with 84 neutrons, is shown to be consistent with its identification as the lowest state of mixed symmetry in the U(5) limit of the neutron-proton version of the interacting-boson model.
Rationale: Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, and that this susceptibility could be genetically determined. Objectives: The aim of the present study was to assess, in a popul
A unique set of gaseous mercury measurements in the upper troposphere and lower stratosphere (UT/LS) has been obtained during the monthly CARIBIC (www.caribic-atmospheric.com) flights since May 2005. The passenger Airbus 340-600 of Lufthansa covered routes to the Far East, North America, India, and the southern hemisphere. The accompanying measurements of CO, O3, NOy, H2O, aerosols, halocarbons, h
Disentangling phylogenetic relationships proves challenging for groups that have evolved recently, especially if there is ongoing reticulation. Although they are in most cases immediately isolated from diploid relatives, sets of sibling allopolyploids often hybridize with each other, thereby increasing the complexity of an already challenging situation. Dactylorhiza (Orchidaceae: Orchidinae) is a
BACKGROUND: Although there have been case reports describing trocar site herniation after laparoscopic fundoplication, its overall prevalence and the risk factors for its development are unclear.METHODS: The records of 320 patients undergoing primary laparoscopic fundoplication as treatment for gastroesophageal reflex disease (GERD) or hiatal hernia between 1991 and 1999 were reviewed retrospectiv
This chapter discusses the role of combinatorial knowledge and its multi-scalarity in shaping the transformation paths of local productive systems that are affected by the gales of contemporary technological change. Analytic knowledge is often created with the application of experiment-based methods. The value is extracted from the application of scientific principles and theoretical modes of lear
Context. The Gaia-ESO Survey (GES) is a large spectroscopic survey that provides a unique opportunity to study the distribution of spectroscopic multiple systems among different populations of the Galaxy. Aims. Our aim is to detect binarity/multiplicity for stars targeted by the GES from the analysis of the cross-correlation functions (CCFs) of the GES spectra with spectral templates. Methods. We
Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were mea
Nitric oxide (NO)‐independent pathways contributing to acetylcholine (ACh)‐induced relaxation were examined in the rat isolated hepatic artery and aorta at low and high levels of precontraction induced by phenylephrine (PhE). In the hepatic artery, the ACh‐induced relaxation was unaffected by the NO synthase inhibitors Nw‐nitro‐L‐arginine (L‐NOARG, 0.3 mM) and Nω‐nitro‐L‐arginine methyl ester (0.1
