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B lymphocyte-induced maturation protein-1 (Blimp-1), the transcription factor encoded by the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result in the maintenance of key effector functions of B- and T-cells. Emerging clinical data, as well as mechanistic evidence from mouse studies, have additionally identified critical functions of Blimp-1 in the maintenance o
Primary ship waves generated by conventional marine vessels were investigated in the Furusund fairway located in the Stockholm archipelago, Sweden. Continuous water level measurements at two locations in the fairway were analyzed. In total, 466 such events were extracted during two months of measurements. The collected data were used to evaluate 13 existing predictive equations for drawdown height
The interactions between protein and surfactants play an important role in the stability and performance of formulated products. Due to the high complexity of such interactions, multi-technique approaches are required to study these systems. Here, an integrative approach is used to investigate the various interactions in a model system composed of human growth hormone and sodium dodecyl sulfate. C
Background: The Evaluation in Ayres Sensory Integration ® (EASI) is a performance-based assessment tool, aiming to assess sensory perception, sensory reactivity, postural/ocular/bilateral integration, and praxis in children aged 3–12 years. These types of tests are currently not available in Swedish. A structured, multistep process of translation is crucial for maintaining equivalence between the
https://www.mdpi.com/2313-5778/4/4/109
Scenarios are a useful tool to help think about and visualise the future and, as such, are utilised by many policymakers and practitioners. Future scenarios have not been used to explore the urban context in much depth, yet have the potential to provide valuable insights into the robustness of decisions being made today in the name of sustainability. As part of a major research project entitled Ur
The CHEOPS space mission dedicated to exoplanet follow-up was launched in December 2019, equipped with the capacity to perform photometric measurements at the 20 ppm level. As CHEOPS carries out its observations in a broad optical passband, it can provide insights into the reflected light from exoplanets and constrain the short-wavelength thermal emission for the hottest of planets by observing oc
In the Protestant tradition the trade and commerce that surrounded different aspects of Catholic spirituality was regarded as something relatively alien. In Protestant Sweden the critique towards these aspects of Catholicism became an essential component in the anti-Catholic rhetoric that was recurring during the latter nineteenth and the early twentieth century. From the perspective of Lutheran t
Although folded proteins are commonly depicted as simplistic combinations of β-strands and α-helices, the actual properties and functions of these secondary-structure elements in their native contexts are just partly understood. The principal reason is that the behavior of individual β- and α-elements is obscured by the global folding cooperativity. In this study, we have circumvented this problem
We have briefly discussed herein four of the many aspects that raise concerns in the context of implementation of whole-exome and whole-genome sequencing (mainly) in the clinical realm. Namely, we addressed issues surrounding: (1) the duty to hunt for variants known to have a health impact, (2) such “hunting” or opportunistic screening in children, (3) challenges to the consent process, and (4) th
This chapter seeks to develop a theoretical basis for better understanding the intersections between public diplomacy (PD) and development communication (Devcom). It will be argued that both fields involve (1) theories of influence over social change in foreign countries; (2) a voluntary transfer of resources from an actor promoting a specific cause or agenda to a group or organization in a foreig
Will technical change spur conflicts in the labor market? In this study, we examine electricity adoption in Sweden during the first decades of the twentieth century. Exploiting that proximity to hydropowered plants shaped the electricity network independently of previous local conditions, we estimate the impact of electricity on labor strikes. Our results indicate that electricity adoption precede
Over the past 50 years Umeå has displayed constant growth, making it the fastest-growing region in northern Sweden. It is therefore crucial that Umeå grows with regards to environmental, social, cultural and economic aspects. Sharing City Umeå, which is a test-bed for the sharing economy, is focusing on innovative solutions for shared mobility, green spaces, resource efficiency, sustainable consum
Objectives: ACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization. Methods: Patients are entered into ACST-2 when revascularization is felt to be clearly indicated, when CEA and CAS are both possible, but where there is substantial uncertainty
Glas- och bärnstenspärlor var en del av dräkten som signalerade bärarens sociala och ekonomiska status. I artikeln presenteras pärluppsättningarna från 25 gravar daterade till yngre romersk järnålder period C1 och C2 funna i dagens Skåne. Pärlorna har ett varierat och unikt uttryck vilket stärker hypotesen att de mindre rika gravarna i Skåne, jämfört med på Själland, beror på ett mer stabilt samhäGlass and amber beads are colourful artefacts that have been much less discussed than other accessories such as fibulae. Like these, the beads were part of the dress that signalled the wearers’ social and economic status. In the article, beads from 25 graves from modern-day Scania, dated to the Roman Iron Age periods C1 and C2, are presented. In many ways they show a varied and unique expression,
Basis pursuit (BP), basis pursuit deNoising (BPDN), and least absolute shrinkage and selection operator (LASSO) are popular methods for identifying important predictors in the high-dimensional linear regression model (Formula presented.). By definition, when (Formula presented.), BP uniquely recovers (Formula presented.) when (Formula presented.) and (Formula presented.) implies (Formula presented
We exploit a large historical shock to the Danish labour market to provide evidence of how restrictions on labour mobility increase monopsony power and thereby reduce wages. By severely limiting the possibility of the rural population to work beyond their place of birth, the reintroduction of serfdom in 1733 aimed to increase monopsony power and secure cheaper labour in the countryside. Using a un
Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration summarizes the evidence linking AF to cognitive impairment and dementia. It provides guidance on the investigation and management of dementia in patients with AF on the basis of b
This article examines the emergence of a ‘migration industry’ as a result of European border externalisation and security outsourcing practices to curb migration flows from Libya. It argues that the management of migration has been partly delegated to a network of interlinked private and public actors which constitute a complex migration governance structure that ultimately gives rise to issues of
