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Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that offer high throughput and good reproducibility are essential in proteomics. Therefore, we implemented efficient paraffin removal and protein extraction from FFPE tissues followed by an optimized two-enzyme digestion using suspension trapping
Efficient and robust control strategies can greatly contribute to the reliability of fuel cell systems, and a stable output voltage is a key criterion for evaluating a fuel cell system's reliability as a power source. In this study, a polymer electrolyte fuel cell (PEFC) system model is developed, and its performances under different operating conditions are studied. Then two different novel contr
This commentary describes a program developed to help reduce the incidence of anterior cruciate ligament injuries in soccer players. The basic principles underlying the injury prevention protocol are described with respect to the proprioceptive control mechanisms at the knee joint. This is followed by a detailed description of the program.
Objectives: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. Patients and methods: Data were extracted from 59 studies, with 16 studies i
The total and differential Higgs boson production cross-sections are measured through a combined statistical analysis of the H → ZZ * → 4ℓ and H → γγ decay channels. The results are based on a dataset of 139 fb−1 of proton–proton collisions at a centre-of-mass energy of 13 TeV, recorded by the ATLAS detector at the Large Hadron Collider. The measured total Higgs boson production cross-section is 5
Aim:Aerobic capacity, defined as peak oxygen uptake (VO2PEAK), is generally considered to be the best single marker for aerobic fitness. We assessed if VO2PEAK is related to different cardiac dimensions in healthy young children on a population base. Methods: In a cross-sectional study, 245 children (137 boys and 108 girls) aged 8-11 years, were recruited from a population based cohort. VO2PEAK (m
For robots to be productive co-workers in the manufacturing industry, it is necessary that their human colleagues can interact with them and instruct them in a simple manner. The goal of our research is to lower the threshold for humans to instruct manipulation tasks, especially sensorcontrolled assembly. In our previous work we have presented tools for high-level task instruction, while in this p
In this paper we investigate the problem of segmenting images using the information in text annotations. In contrast to the general image understanding problem, this type of annotation guided segmentation is less ill-posed in the sense that for the output there is higher consensus among human annotations. In the paper we present a system based on a combined visual and semantic pipeline. In the vis
Popular Abstract in Swedish Neuroblastom är den vanligaste solida tumören, utanför hjärnan, hos små barn och finns nästan inte alls hos vuxna. Varje år insjuknar mellan femton och tjugo barn i Sverige, de flesta före två års ålder. Överlevnaden har ökat de senaste tjugo åren men är fortfarande på låga nivåer för de mer aggressiva formerna. Neuroblastom uppstår i det sympatiska nervsystemet. DärförIn this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. Our first focus was on one of the most important biological risk factors in neuroblastoma -- amplification of the oncogene MYCN in the tumour cells. Because amplified MYCN typical
Liksom en trädstam uppvisar årsringar som kan användas för att beräkna dess ålder, bildas också tillväxtringar i tänderna hos många djur, även hos dem som regelbundet byter tanduppsättning. Detta fenomen noterades av paleontologen Richard Owen redan i mitten av 1800-talet, men det är först de senaste decennierna som forskningen inom tandersättningscykler hos utdöda djur har tagit fart. Så kalladeThe dentine of teeth from five genera of mosasaurs [i.e., Clidastes, Halisaurus, Dollosaurus (Prognathodon),cf. Platecarpus, and Tylosaurus] and a Mesozoic crocodylian (Aigialosuchus) from the Campanian of the Kristianstad Basin, southernmost Sweden, displays two types of incremental growth lines; i.e., von Ebner’s and, for the first time in extinct animals, Andresen’s lines. These lines are homol
We propose an adaptive change point detection method (A-CPD) for machine guided weak label annotation of audio recording segments. The goal is to maximize the amount of information gained about the temporal activations of the target sounds. For each unlabeled audio recording, we use a prediction model to derive a probability curve used to guide annotation. The prediction model is initially pre-tra
For classical tomography, it is essential that the sample does not change during the acquisition of one tomographic rotation. We derived and successfully implemented a tomographic reconstruction method, which relaxes this requirement of quasistatic samples. In the present paper, dynamic tomographic data sets are decomposed in the temporal domain by projecting to a lower dimensional subspace of bas
Wikipedia has become a reference knowledge source for scores of NLP applications. One of its invaluable features lies in its multilingual nature, where articles on a same entity or concept can have from one to more than 200 different versions. The interlinking of language versions in Wikipedia has undergone a major renewal with the advent of Wikidata, a unified scheme to identify entities and their
When it comes to religion, lack of conclusive evidence leads many reflective thinkers to embrace agnosticism. However, pure agnosticism does not necessarily have to be the final word; there are other attitudes one might reasonably adopt in a situation of epistemic uncertainty. This article concentrates on J. L. Schellenberg's proposal that non-doxastic propositional faith is available even when be
The association of markers of myocardial injury and dysfunction with infarct size (IS) and ejection fraction (EF) are well documented. However, limited data are available on the newer high-sensitivity troponin assays and comparison with morphologic and functional assessment with cardiac magnetic resonance imaging. We aimed to examine the associations of high-sensitivity cardiac Troponin-T (hs-cTnT
