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In this paper a methodological approach for the analysis of nonstationary heart rate variability (HRV) signals using time-varying frequency bands based on respiratory frequency is presented. Spectral analysis of HRV is accomplished by means of the Smoothed Pseudo Wigner Ville distribution. Different approaches to the definition of the low frequency (LF) and high frequency (HF) bands are considered

Joseph Beuys. Fat and felt. A critical essay. The extremely singular materials fat and felt for use in art, have an entirely dominating role in a long series of Joseph Beuys’ (1921-1986) most important work. They are found both in single works of art as well as in installations and happenings from the beginning of the 1960s and up to the end of the artist’s life. This essay deals with the artist’

Even though there is a constant and accelerating growth of the aging population worldwide, such a rapid rise is negatively impacting available home and community services not able to encompass the necessities associated with the increased number of older people. In particular, there are increasing demands on e-health care services and smart technologies needed for frail elders with chronic disease

Globally, an enormous number of polluted areas are in need of remediation to prevent adverse effects on health and environment. In situ remediation and especially the monitoring thereof needs further development to avoid costly and hazardous shipments associated with excavation. The monitoring of in situ remediation actions needs easier and cheaper nondestructive methods for evaluation and verific

Angiogenesis occurs early in tumor development, sustains primary tumor growth and provides a route for metastatic escape. The TGF-β family receptors modulate angiogenesis via endothelial-cell specific pathways. Here we investigate the interaction of two such receptors, ALK1 and endoglin, in pancreatic neuroendocrine tumors (PanNET). Independently, ALK1 and endoglin deficiencies exhibited genetical

Soft tissue tumors (STT) constitute a heterogeneous group of tumors that arise in tissues of mesenchymal origin. They are currently classified according to morphology and resemblance to normal tissue into over 100 subtypes. Differentiation between the different subtypes can sometimes be difficult, and along with the fact that little is known about the mechanisms of STT development, this makes adeq

Olfaction presents a particularly interesting arena to explore abstraction in language. Like other abstract domains, such as time, odours can be difficult to conceptualize. An odour cannot be seen or held, it can be difficult to locate in space, and for most people odours are difficult to verbalize. On the other hand, odours give rise to primary sensory experiences. Every time we inhale we are usi

Background: Occurrence of severe asthma exacerbations are the cornerstone of the evaluation of asthma management, but severe asthma exacerbations are rare events. Therefore, trials that assess drug efficacy on exacerbations are done late in clinical development programmes. We aimed to establish an endpoint capturing clinically relevant deteriorations (diary events) that, when combined with severe

Assistive products may elicit unpleasant feelings within both the actual user and persons around. By analysing two complementary studies, this paper tries to illuminate which unpleasant feelings may be elicited. In study A industrial design students evaluated assistive products. In study B young persons with disabilities were interviewed about their everyday experiences. Negative statements by par

The papilloma- and polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. Detection of specific antibodies to these viruses allows tracking past and present infections to elucidate natural history and association of infection with subsequent disease. As there are

Humans and animals communicate with rhythmic behaviours that vary greatly in terms of temporal parameters and patterns. In this chapter we discuss the neuromuscular architecture underlying rhythmic behaviours and address factors that constrain their rhythmic properties. In Part I of the chapter we provide background regarding the building blocks of rhythmic communication from the muscles to the br

BACKGROUND: Weight-adjusted-waist index (WWI) is an anthropometric index reflecting fat mass and muscle mass, both of which are important factors influencing insulin resistance and inflammation.OBJECTIVES: We aimed to examine the associations of WWI with all-cause, cardiovascular, and noncardiovascular mortality among individuals with type 2 diabetes (T2D) and further investigate whether insulin r

Background: Drug-related problems are common in older individuals. A medication reconciliation has the goal of identifying and maintaining an accurate medication list and can serve to prevent drug-related problems caused by discrepancies. Objectives: This study aimed to explore primary care physicians’ intentions towards performing medication reconciliation in patients with multimorbidity using a

Introduction: South Africa has one of the highest incidence rates of notified tuberculosis (TB) in the world. Achieving TB control requires strengthening treatment and support services. The implementation of differentiated delivery models can be used to improve service quality and enhance retention in care. This study aimed to identify treatment and support delivery preferences among people on TB

Background This prospective cohort study aimed to assess whether postoperative radiotherapy could safely be omitted in women aged 65 years and older with low-risk, estrogen receptor-positive T1N0 breast cancer treated with breast-conserving surgery and adjuvant endocrine therapy. Methods Eligible patients were women aged 65 years and older with unifocal, nonlobular, grade 1 or 2, estrogen receptor

RATIONALE: Caffeine is commonly used in preterm infants to improve respiratory function. However, the optimal strategies for caffeine initiation have not been defined. OBJECTIVES: To evaluate the relative benefits and harms of different indications and timings for caffeine initiation in preterm infants. SEARCH METHODS: We searched MEDLINE, Embase, CENTRAL, and trial registries up to 23 April 2025.

We present the design of the vacuum chamber for the LNLS 2T Hybrid Wiggler. The chamber is a 3m long, 1.2mm thick 316L SS tube, which was mechanically pressed into an elliptical shape from an originally round tube. In order to provide the necessary mechanical tolerances, the rather flexible tube is welded to lateral supports that run the complete length of the chamber. Special care has been given