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Context: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are cleaved by dipeptidyl peptidase-4 (DPP-4); plasma activity of DPP-4 may be increased in obesity. The impact of this increase on incretin hormone secretion and metabolism is not known. Objective: The aim of the study was to assess incretin hormone secretion and degradation in lean and obese nondiabet

Coeliac disease (CD) is becoming a model for understanding the pathogenesis of autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis (RA) with both anti-citrullinated protein antibodies (ACPA) and auto-antibodies against the citrullinating enzyme, peptidylarginine deiminas

Objective: The minor G allele of FOXO3A rs2802292 has been associated with longevity. We aimed to investigate whether a phenotype related to healthy metabolic aging could be identified in individuals carrying the longevity-associated FOXO3A rs2802292 G allele. Research Design and Methods: rs2802292 was genotyped in a phenotypically well-characterized population of young and elderly twins (n = 190)

Context: Arginine vasopressin (AVP) is known to affect liver glycogenolysis, insulin, and glucagon secretion and pituitary ACTH release. We previously showed that high copeptin, the stable C-terminal fragment of AVP prohormone, is independently associated with hyperinsulinemia and future development of diabetes mellitus. Objective: The objective of the study was to examine whether plasma copeptin

The genetic basis of complete C4 deficiency in a patient with SLE was investigated. Previous studies have demonstrated that this patient has two different major histocompatibility complex (MHC) haplotypes that each contain a major deletion and a non-expressed C4 gene. In the present study, non-expression of the C4 genes was explained by the finding of two distinct C4 gene mutations. A previously d

An integrated cell cultivation and protein product separation process was developed using a new type of supermacroporous polyacrylamide gel, called cryogel (pAAm-cryogel) support matrix. Human fibrosarcoma HT1080 and human colon cancer HCT116 cell lines were used to secrete urokinase (an enzyme of immense therapeutic utility) into the culture medium. The secreted protein was isolated from the circ

Atmospheric mercury species/fractions were measured near a chlor-alkali plant in Sweden during August 28 to September 4, 2001. The concentration of total gaseous mercury in the plume from the plant was measured using TEKRAN and GARDIS instruments. Gaseous elemental mercury was measured using a light detection and ranging (LIDAR) technique. From vertical LIDAR sweeps through the plume from the chlo

Edon80 is a recent stream cipher design that has advanced to the third and last phase of the eSTREAM project. It has remained unbroken and untweaked since it was designed and submitted to eSTREAM. It is now one of the 8 final hardware candidates. In this paper we cryptanalyze the cipher by describing a key recovery attack. The complexity of the attack is around 269 simple operations for a keystrea

Cytokines direct the differentiation of naive CD4(+) T cells into either IFN-gamma-producing T(h)1 cells or IL-4-producing T(h)2 cells. In this study, we analyzed the activation of signal transducer and activator of transcription (STAT)1, STAT3 and STAT5 (together with STAT4 and STAT6), and the expression of the recently identified suppressor of cytokine signalling (SOCS) proteins, in differentiat

Let us have an NLFSR with the feedback function g(x) and an LFSR with the generating polynomial f(x). The function g(x) is a Boolean function on the state of the NLFSR and the LFSR, at any time instance t. Whenever the LFSR has good statistical properties, it is used for controlling the randomness of the NLFSR's state machine. In this paper we define and study the general class of "Grain" family o

Abstract in Undetermined In media, policymaking and research, increasing attention is drawn to the phenomenon of ‘green political consumerism’, referring to consumerrelated practices that are based on concerns beyond the traditional criteria of product quality and price. Political consumerism is about expressing non-economic values, that is, values beyond the direct, economic self-interest of cons

This paper presents an energy relaxation-based approach for the modeling of single crystalline magnetic shape memor)) alloy response under general two-dimensional magnetomechanical loading. It relies on concepts of energy relaxation in the context of non-convex free energy landscapes whose wells define preferred states of straining and magnetization. The constrained theory of magnetoelasticity dev

Popular Abstract in Swedish Att opereras via titthålskirurgi eller öppen kirurgi med en operationsteknik som förhindrar sura uppstötningar och halsbränna - en slumpmässig jämförande studie från ett patientperspektiv Utdrag ur avhandlingen Laparoscopic or open surgery - A comparative study with special reference to the patient's perspective av Gunilla Nilsson Vad är problemet? Gastroesofageal reThe overall aim of this thesis was to compare the effects of laparoscopic versus open antireflux surgery in a randomized clinical trial focusing the patients' subjective and objective outcome postoperatively, from a short-term and a long-term perspective. A further aim was to describe GORD patients' experiences of illness and surgical treatment and if possible to find striking characteristics rela

Adaptive tracking of non-linear dynamic plants is currently an important area of research. The main difficulty being felt by the research community is the lack of a general modelling framework that can facilitate synthesis of a simplistic control law while being capable of providing accurate approximation of non-linear systems. In this study a novel technique based on the control-oriented U-model

Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor suppressor genes that are located 3 Mb apart and that underlie the hereditary syndromes pituitary ad

Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently require

The ultrafast carotenoid band shift upon excitation of nearby bacteriochlorophyll molecules was studied in three different light harvesting complexes from purple bacteria. The results were analyzed in terms of changes in local electric field of the carotenoids. Time dependent density functional theory calculations based on known and model structures led to good agreement with experimental results,

Radiative lifetimes of 16 odd levels belonging to the 4d(2)5p configuration of Zr II have been measured using a time-resolved laser-induced fluorescence technique with a single-step excitation process either from the ground state or from metastable levels belonging to the 4d(2)5s and 4d(3) configurations. For 12 levels, there were no previous results available. The new experimental results and the