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New-onset atrial fibrillation among patients with infection in the emergency department : A multicentre cohort study of one-year stroke risk

BACKGROUND: Patients with new-onset atrial fibrillation in relation to infection are frequent in emergency departments (ED) and may require antithrombotic therapy due to increased risk of stroke. Our objective was to describe the one-year risk of stroke in ED patients with infection, new-onset atrial fibrillation and no antithrombotic therapy.METHODS: Population-based cohort study at four EDs in D

Nuclear magnetic resonance relaxation in micelles : Deuterium relaxation at three field strengths of three positions on the alkyl chain of sodium dodecyl sulphate

A 2H n.m.r. relaxation study of sodium dodecyl sulphate (SDS) in the micellar phase is presented. The surfactant is specifically deuterated in the α-, γ- and ω-positions. Relaxation data are obtained at two temperatures and at three field strengths, and show a dependence on the field strength. The data are analysed with the 'two-step' model of relaxation, and the fast correlation times as well as

FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes

The glutamate transporter 1 (GLT1) is upregulated during astrocyte development and maturation in vivo and is vital for astrocyte function. Yet it is expressed at low levels by most cultured astrocytes. We previously showed that maturation of human and mouse stem cell-derived astrocytes - including functional glutamate uptake - could be enhanced by fibroblast growth factor (FGF)1 or FGF2. Here, we

QREME – Quality requirements management model for supporting decision-making

[Context and motivation] Quality requirements (QRs) are inherently difficult to manage as they are often subjective, context-dependent and hard to fully grasp by various stakeholders. Furthermore, there are many sources that can provide input on important QRs and suitable levels. Responding timely to customer needs and realizing them in product portfolio and product scope decisions remain the main

Locally administered bisphosphonate in hip stem revisions using the bone impaction grafting technique : a randomised, placebo-controlled study with DXA and five-year RSA follow-up

Background: Bisphosphonates have previously been shown to increase the density of impacted graft bone. In the present study we hypothesise that bisphosphonates also reduce early stem subsidence. We examined the effect of locally applied bisphosphonate to allografts on prosthetic micromotion and bone density in femoral stem revision with impaction grafting. Methods: 37 patients were randomised to e

Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice

Within the hematopoietic system, the Notch pathway is critical for promoting thymic T cell development and suppressing the B and myeloid lineage fates; however, its impact on NK lymphopoiesis is less understood. To study the role of Notch during NK cell development in vivo, we investigated different NK cell compartments and function in Rbp-Jkfl/flVav-Cretg/+ mice, in which Rbp-Jk, the major transc

At the Cross Section of Thrombotic Microangiopathy and Atypical Hemolytic Uremic Syndrome : A Narrative Review of Differential Diagnostics and a Problematization of Nomenclature

Complement-mediated atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with high mortality and morbidity. Renal biopsies often indicate thrombotic microangiopathy (TMA). The condition is caused by an excessive activation of the alternative pathway leading to depositions of membrane attack complexes (MAC) on host cells. It may depend on mutations in complement components and reg

Serum microRNAs in male subfertility—biomarkers and a potential pathogenetic link to metabolic syndrome

Purpose: The purpose of the study was to identify serum microRNAs providing a link between male subfertility and metabolic syndrome (MetS) and validate their diagnostic potential. Methods: Sera were analyzed for fertility and MetS-related parameters in subfertile men (n = 79) and controls (n = 38). Literature review identified miR-155-5p, miR-122-5p, miR-200a-3p, and miR-200c-3p which previously w

Forests : the cross-linguistic perspective

Do all humans perceive, think and talk about tree cover (‘forests’) in more or less the same way? International forestry programs frequently seem to operate on the assumption that they do. However, recent advances in the language sciences show that languages vary greatly as to how the landscape domain is lexicalized and grammaticalized. Different languages segment and label the large-scale environ

Malaria, Immunity, and Immunopathology

Malaria is a disease spread by mosquitoes, and it is a major global cause of morbidity and mortality. Most of the deaths in malaria are caused by the Apicomplexan parasite Plasmodium falciparum. Immunity against the disease is dependent on repeated exposure, and it usually takes several years to develop. Antibodies against different antigens are an important part of immunity, but cellular immunity

Antibody heavy chain variable domains of different germline gene origins diversify through different paths

B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve, e.g., base substitution, codon insertion and deletion, often in association with an isotype switch. Investigations of antibody evolution define modes whereby particular antibody responses are able to form

Decontextualisation of Street Art

This chapter discusses the increasing tendency to remove street art from its original site for personal gain. It further explores whether/how copyright claims can be an effective means of preventing such extractions.

The Swedish experience of rehabilitation robotics

Over the last ten years, there has been a great deal of research and development in Sweden in the field of rehabilitation robotics. The research effort has often focused on workplace adaptations. This paper deals with four robotic adaptations, all of whic

Computer supported visualization to support continuous improvements within quality systems

This paper presents a study wherein computer supported visualization is used to design and enhance understanding of quality systems. The study attempts to discover if a quality system such as ISO 9000 can be visualized, and how the visualization should be designed in order to support continuous improvement. Three companies in southern Sweden have set up special groups (here called design groups) w

The Loshult arrows: cultural relations and chronology

In 1951 two arrows were found close to each other in the bog Lilla Loshults Mosse in northernmost Scania, southern Sweden. These arrows are of major importance for the study of the early Mesolithic as the arrowheads, including points and barbs made of flint, were still attached to the shafts. The arrows have been dated to the Early Boreal chronozone by pollen analyses of the attached peat. The ar