Sökresultat

Glucose-evoked insulin secretion exhibits a biphasic time course and is associated with accelerated intracellular granule movement. We combined live confocal imaging of EGFP-labelled insulin granules with capacitance measurements of exocytosis in clonal INS-1 cells to explore the relation between distinct random and directed modes of insulin granule movement, as well as exocytotic capacity. Reduci

We report the first experimental measurements and theoretical calculations for the hyperfine splitting of the 3d(5) 4s ground state of Mn II. The hyperfine structure constants were determined using Fourier transform spectroscopy with a hollow cathode discharge lamp. The uncertainties in the magnetic dipole constants, A, are between 3 x 10(-4) and 5 x 10(-4) cm(-1). Extensive configuration interact

Immunization of mice with type II collagen (CII), a cartilage-restricted protein, leads to collagen-induced arthritis (CIA), a model for rheumatoid arthritis (RA). CIA symptoms consist of an erosive joint inflammation caused by an autoimmune attack, mediated by both T and B lymphocytes. CD4+ alphabeta T cells play a central role in CIA, both by helping B cells to produce anti-CII antibodies, and b

Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutati

We used a series of CO⁵BOLD hydrodynamical model atmospheres covering stellar objects from white dwarfs to red giants to derive theoretical estimates of the photometric and photocentric stellar variability in wavelength-integrated light across the Hertzsprung-Russell diagram. We validated our models against solar measurements from the SoHO/VIRGO instrument. Within our set of models we f

Popular Abstract in Swedish Del 1. Introduktion I kapitel 1 presenteras arbetets problem, syfte och metod. Det arbete som olika frivilligorganisationer och deras medlemmar utför har de senaste åren uppmärksammats alltmer. Detta ökade intresse finner man såväl i Sverige som internationellt. Fokus i detta arbete riktas mot drivkrafterna bakom frivilligt engagemang. Det övergripande problemet är varfThis thesis focuses on the incitement to commitment and voluntary work. The overall problem is the question why you get involved in voluntary work for an organisation like Lutherhjälpen, the organisation for international development co-operation of the Church of Sweden, one of the largest NGOs of the country. The theoretical perspectives are seen from the position of the increasing pace of change

Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays are being developed for these purposes, it is important to optimize and standardi

OBJECTIVE: Topical negative pressure therapy has excellent healing effects in poststernotomy mediastinitis. Topical negative pressure therapy reduces bacterial counts, increases wound edge microvascular blood flow and granulation tissue formation, and facilitates healing. No study has yet been performed to examine the effect of topical negative pressure on the blood and fluid content in the sterna

Aims In a cohort of men and women with Type 1 diabetes, prospectively followed for > 20 years, vibrotactile sense in fingers was investigated and related to neurophysiological tests, glycaemic level and clinical score. Methods Out of 58 patients, diagnosed at the age of 15-25 years and recruited 1984-1985, 32 patients (13 women, median age 52 years, range 44-75 years; 19 men, median age 52 years,

Popular Abstract in Swedish Minns du din första dator? Kanske köpte familjen den på avbetalning genom jobbet för 20 000 kr och kanske kan du såhär i efterhand tycka att effektförbrukningen var lite väl hög i relation till datorns prestanda. Den gick t.ex. inte att köra på batteri. Detta är ganska långt ifrån dagens datorer, smart-TV, smarta telefoner och surfplattor där vi kan streama filmer och mThis thesis explores a novel transistor technology based on vertical InAs nanowires, which could be considered both for low-power high-frequency analog applications and for replacing Si CMOS in the continued scaling of digital electronics. The potential of this device - the vertical InAs nanowire MOSFET – lies in the combination of the outstanding transport properties of InAs and the improved elec

The recruitment of antigen-specific T lymphocytes to the intestinal mucosa is central to the development of an effective mucosal immune response, yet the mechanism by which this process occurs remains to be fully defined. Here we show that the CC chemokine receptor 9 (CCR9) is selectively and functionally expressed on murine alpha(E)beta(7)(+) naive CD8alphabeta(+) lymphocytes and a subset of rece

Purpose – The purpose of this paper is to systematically and critically review the extant literature on the design of global production and distribution networks to identify gaps in the literature and identify future research opportunities. The design aspects deal with strategic and structural decisions such as: opening or closing of manufacturing plants or distribution centres, selection of locat

In this paper we present and discuss some of the lessons learnt from the completed CoLabs.eu project within the so called R3L-initiative on European Networks of Learning Regions. In the project we made some concrete social experiments in order to “make the village a virtual campus”. We start this paper by making a general introduction to the research area and by giving the motivating background to

A fundamental difference between ordinary and leisure time is for many the ability to indulge in extra-ordinary activities of both body and mind. Rooted in antiquity, the renaissance villas were often used as spaces for indulgence of artistic endeavors, be it philosophical discussions, poetry-writing or lavish parties. Of indulgence, Aristoteles wrote: ‘The self-indulgent man craves for all pleasa

The complement system resembles a double-edged sword since its activation can either benefit or harm the host. Thus, regulation of this system is of utmost importance and performed by several circulating and membrane-bound complement inhibitors. The pool of well-established regulators has recently been enriched with proteins that either share structural homology to known complement inhibitors such