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Contribution of plasma-derived molecules to mucosal immune defence, disease and repair in the airways

This review discusses recent observations, in health and disease, on the release and distribution of plasma-derived molecules in the airway mucosa. Briefly, the new data on airway mucosal exudation mechanisms suggest that the protein systems of plasma contribute significantly to the mucosal biology, not only in injured airways but also in such mildly inflamed airways that lack oedema and exhibit n

Crystallization and X-ray diffraction analysis of a novel surface-adhesin protein: protein E from Haemophilus influenzae.

Protein E (PE) is a ubiquitous multifunctional surface protein of Haemophilus spp. and other bacterial pathogens of the Pasteurellaceae family. H. influenzae utilizes PE for attachment to respiratory epithelial cells. In addition, PE interacts directly with plasminogen and the extracellular matrix (ECM) components vitronectin and laminin. Vitronectin is a complement regulator that inhibits the for

Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.

High hyperdiploid acute lymphoblastic leukemia (ALL) is one of the most common malignancies in children. It is characterized by gain of chromosomes, typically +X, +4, +6, +10, +14, +17, +18, and +21,+21; little is known about additional genetic aberrations. Approximately 20% of the patients relapse; therefore it is clinically important to identify risk-stratifying markers. We used SNP array analys

Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatment.

OBJECTIVES: The purpose of this study was to determine whether statin treatment is effective and safe in very elderly (80 years and older) acute myocardial infarction (AMI) patients. BACKGROUND: Elderly individuals constitute an increasing percentage of patients admitted to hospitals for AMI. Despite that these patients have a higher mortality risk, the application of evidence-based medicine remai

Informal and formal support from a multi-disciplinary perspective: a Swedish follow-up between 80 and 82 years of age

This longitudinal study used a multi-disciplinary approach and examined the relationship between psychosocial and health characteristics and the pattern of informal and formal support for non-institutionalized very old people. The data were derived from a single cohort of 80-year-old people living in Lund, Sweden who were followed over a 3-year period. In order to account for potential sample bias

Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner.

Context: Low birth weight (LBW) and unhealthy diets are risk factors of metabolic disease including type 2 diabetes (T2D). Genetic, nongenetic, and epigenetic data propose a role of the key metabolic regulator peroxisome proliferator-activated receptor gamma, coactivator 1alpha (PPARGC1A) in the development of T2D. Objective: Our objective was to investigate gene expression and DNA methylation of

En studie om sambandet mellan priselasticitet och konsumenters lojalitet för livsmedel i Sverige

Vår studie visade att det fanns ett samband mellan marknadsandel och lojalitet. Vidare vad gäller sambandet mellan lojalitet och priselasticitet samt pris och lojalitet hittades inget samband eftersom denna var väldigt svag.Our study showed that there is a relationship between market share and loyalty. Regarding the relationship between loyalty and price elasticity and price and loyalty, the study shows a very weak correlation. Thus the conclusion that there is no correlation .

Water use efficiency in agricultural irrigation in Egypt: A qualitative study on the complexities of utilising fossil groundwater resources in the face of water scarcity

This study examines the adaptive capacity of desert farming in Egypt to imminent water scarcity and discusses the sustainability of fossil groundwater extraction. Through qualitative semi-structured expert interviews, the study identifies clear research and data gaps related to the Nubian Sandstone Aquifer System (NSAS) and highlights the need for a nuanced approach to fossil groundwater extractio

Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study

Objectives: The aim of this study was to evaluate the efficacy of the natural antioxidant astaxanthin in functional dyspepsia in different doses and compared with placebo. Design: The study was a controlled, prospective, randomized, and double blind trial. Participants: Patients with functional dyspepsia, divided into three groups with 44 individuals in each group (placebo, 16 mg, or 40 mg astaxan

Classifying ovarian tumors using Bayesian Multi-Layer Perceptrons and Automatic Relevance Determination: A multi-center study

Ovarian masses are common and a good pre-surgical assessment of their nature is important for adequate treatment. Bayesian Multi-Layer Perceptrons (MLPs) using the evidence procedure were used to predict whether tumors are malignant or not. Automatic Relevance Determination (ARD) is used to select the most relevant of the 40+ available variables. Cross-validation is used to select an optimal combi

Organometal Halide Perovskite Solar Cell Materials Rationalized: Ultrafast Charge Generation, High and Microsecond-Long Balanced Mobilities, and Slow Recombination

Organometal halide perovskite-based solar cells have recently been reported to be highly efficient, giving an overall power conversion efficiency of up to 15%. However, much of the fundamental photophysical properties underlying this performance has remained unknown. Here, we apply photoluminescence, transient absorption, time-resolved terahertz and microwave conductivity measurements to determine

Relationship between condensed tannin structures and their ability to precipitate feed proteins in the rumen

BACKGROUND Tannins can bind to and precipitate protein by forming insoluble complexes resistant to fermentation and with a positive effect on protein utilisation by ruminants. Three protein types, Rubisco, rapeseed protein and bovine serum albumin (a single high-molecular weight protein), were used to test the effects of increasing concentrations of structurally different condensed tannins on prot

Performance of the AGATA Gamma-ray Spectrometer in the PreSPEC Set-up at GSI

In contemporary nuclear physics, the European Advanced GAmma Tracking Array (AGATA) represents a crucial detection system for cutting-edge nuclear structure studies. AGATA consists of highly segmented high-purity germanium crystals and uses the pulse-shape analysis technique to determine both the position and the energy of the γ-ray interaction points in the crystals. It is the tracking algorithms

The Political Voice of the Czech Women´s Movement : A Study of Gender Oriented Organizations in the Czech Republic and Their Channels of Influence

UPPSATSEN ÄR SKRIVEN I ÄMNET TJECKISKA (KURS TJE252). The history of gender equality in the Czech Republic i's long and diverse. Thi's thesi's aim's to provide a concise mapping of it's development, with the purpose to illustrate and explain factor's that have consequence's to thi's day. The principal focu's of the study i's the civic women''s movem

Spatial heterogeneity of soil CO2 efflux at ADVEX site Norunda in Sweden

Denna studie undersöker den rumsliga variationen i markens koldioxid-utflöde (CO2) i en boreal blandskog, huvudsakligen dominerad av tall (Pinus sylvestris L.) och gran (Picea abies L.) i ADVEX experimentsite i Norunda, centrala Sverige. Mätningar av markens CO2 gjordes i 72 collars omkring huvudtornet med hjälp av en LI-6250 infraröd gasanalysapparat kopplad till en hemmagjord mörkkammare. MedelvThis study investigates the spatial variation in soil carbon dioxide (CO2) efflux in a boreal mixed forest mainly dominated by Scots pine (Pinus sylvestris L.) and Norway spruce (Picea abies L.) in the ADVEX expermental site in Norunda, in central Sweden. Soil CO2 efflux measurements were performed in 72 collars around the main tower by using a portable LI-6250 infrared gas analyzer connected to a