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By partitioning a hardware design into several blocks and adjusting the voltage of the different blocks individually, an overall power consumption reduction is possible. An algorithm and a hardware solution for assigning two supply voltages to a design divided into blocks is presented. The two supply voltages are optimized using an on-chip controller. The on-chip controller assigns one of the two
The role of T cells in the mouse collagen-induced arthritis (CIA) model for rheumatoid arthritis is not clarified, and different results have been reported concerning the role of CD4 and CD8 T cells. To address this issue, we have investigated B10.Q mice deficient for CD4 or CD8. The mice lacking CD4 were found to be less susceptible to disease, but not completely resistant, whereas the CD8 defici
Background: Communication is a key tool in the nursing profession. It is known that listeners are sensitive to the speaker's voice and interpret the speaker's intentions primarily from the non-verbal signal conveyed. Aim: To map and discuss the current state of knowledge and research evidence on professional voice use in health and nursing care. Design and Method: A scoping review adherent to the
Several stars show deep transits consistent with discs of roughly seen at moderate inclinations, likely surrounding planets on eccentric orbits. We show that this configuration arises naturally as a result of planet-planet scattering when the planets possess satellite systems. Planet-planet scattering explains the orbital eccentricities of the discs' host bodies, while the close encounters during
Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden.
Young people have been prominent climate advocates globally and they are also becoming increasingly visible in global climate politics. They have participated in Conferences of the Parties (COPs) to the United Nations Framework Convention on Climate Change (UNFCCC) since COP1 in 1995. While recent studies have started to examine the representativeness and participation of youth at the COPs, we sti
This book challenges earlier understandings of early modern dissertations as unimaginative academic exercises. It argues for their continuous importance in scholarly and scientific discourse, and describes the richness and diversity of their subjects and themes. The book contains a complete catalogue of the almost 20,000 Swedish dissertations defended in Uppsala, Lund and Åbo, 1600 to 1820. The ca
This chapter explores the relationship between long-term exposure to neighborhood income inequality and adult mortality in Landskrona during a period of declining economic disparities. Using geocoded data from 1939 to 1967, the authors examine three interconnected hypotheses concerning income inequality and longevity. The analysis considers spatial changes in neighborhood inequality over time and
Attempts to measure social mobility before the twentieth century are frequently hampered by limited data. In this paper, we use a new source – annual, matched tax censuses over more than 70 years – to calculate intragenerational income mobility within a preindustrial, settler society, the Dutch and British Cape Colony at the southern tip of Africa. Our unique source allows us to measure income mob
Quantification of in vivo proton magnetic resonance spectra (1H-MRS) still commonly involves evaluation of exclusively the real part of acquired spectral signals, but ignoring the information contained in the imaginary component may limit precise identification of individual metabolite contributions. Here, we assess quantification precision relative to SNR and noise correlation for both real and c
Gene amplification is a crucial process in cancer development, leading to the overexpression of oncogenes. It manifests cytogenetically as extrachromosomal double minutes (dmin), homogeneously staining regions (hsr), or ring chromosomes (r). This study investigates the prevalence and distribution of these amplification markers in a survey of 80 131 neoplasms spanning hematologic disorders, and ben
Scaling up of Lipozyme-catalyzed ester synthesis with >99% conversion and a reflux trap to remove product water from the reaction mixture is reported. Ethyl stearate was synthesized in 2000-g batch reactions from technical stearic acid. The ethyl stearate was purified to 97% by crystallization and interesterified with sunflower seed oil by means of a lipase catalyst to investigate reaction paramet
IGF-1 is an essential regulator of fetal growth and brain development. Preterm birth in the human is followed by a rapid decrease in serum levels of IGF-1 and decreased levels of IGF-1 have been associated with development of severemorbidity. A recent clinical trial indicated that supplementation with IGF-1 prevented development of severe intraventricular hemorrhage (IVH) in extremely preterm infa
Circulating tumor cells (CTCs) may provide a liquid biopsy approach to disease monitoring in small cell lung cancer (SCLC), a particularly aggressive tumor subtype. Yet, the prognostic role of CTCs during and after treatment in relation to baseline remains ill-defined. Here, we assessed the value of longitudinal CTC analysis and the potential of low-molecular-weight heparin (LMWH) to reduce CTC ab
Presents a two-dimensional stochastic convection-diffusion model for use in real-time prediction of the space-time rainfall structure in urban areas. The model is used to parameterize the rainfall intensity from individual rain cells. Especially, we are interested to quantify the rainfall intensity resulting from different separable components of the rain cell. This is done by a Lagrangian approac
