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Single-shot, spatially-resolved stand-off detection of atomic hydrogen via backward lasing in flames

We report on an experimental demonstration of spatially-resolved detection of atomic hydrogen in flames using a single-ended configuration yielding 656-nm lasing in the backward direction upon 2-photon pumping with 205-nm femtosecond laser pulses. Spatial resolution is achieved by temporally-resolved detection of the backward lasing using a streak camera. The method is demonstrated in CH4/O2 flame

CATES (Consequence assessment tool for pipelines emergency situations)

The task of assessing the extent of a gas release during pipeline emergency situations is challenging. Traditional methodologies for risk analysis require significant computer capabilities and time; factors that have traditionally made emergency response teams unable to use gas dispersion modelling during real incidents.

The transcription factor ANAC017 is a key regulator of mitochondrial proteotoxic stress responses in plants

Impaired mitochondrial translation or reduced mitochondrial protein import can lead to imbalances in mitochondrial protein composition. Such mitochondrial proteotoxic stresses can trigger a nuclear transcriptional response commonly described as the mitochondrial unfolded protein response (UPRmt). Despite extensive studies of UPRmt pathways in animal and fungal systems, very little is known about h

Host transcriptional responses to high-and low-virulent avian malaria parasites

The transcriptional response of hosts to genetically similar pathogens can vary substantially, with important implications for disease severity and host fitness. A low pathogen load can theoretically elicit both high and low host responses, as the outcome depends on both the effectiveness of the host at suppressing the pathogen and the ability of the pathogen to evade the immune system. Here, we i

Risk and operation optimized damage detection and inspection systems

Damage detection systems are usually developed and optimized based on the methods of damage detection system reliability. This implies that the later purpose of a damage detection system namely e.g. the employment of the structural integrity management is not directly accounted for. This paper addresses thus the issue of optimizing a damage detection system in the perspective its utilization for t

Propagation of Darrieus-Landau unstable laminar and turbulent expanding flames

The propagation of laminar and turbulent expanding flames subjected to Darrieus-Landau (DL), hydrodynamic instability was experimentally studied by employing stoichiometric H2/O2/N2 flames under quiescent and turbulent conditions performed in a newly developed medium-scale, fan-stirred combustion chamber. In quiescent environment, DL unstable laminar flame exhibits three-stage propagation, i.e. sm

Characterization of FEL spectra using specific figures of merit

There is an increasing demand from the user community for high quality FEL radiation. The spectrum of this radiation can prove to be a useful tool in characterizing the FEL process. Starting from a tool initially developed at FERMI we extend its capabilities to be able to analyze the modal components of the FEL spectrum. In this paper we will describe and compare two different figures of merit and

The future of sustainability projects: Flights of fancy or a threnody to a lost age?

Just like a living organism, also the project has an anatomy, a life span and a purpose. A project has its given actors, given timeframe and phases, and a given goal. Towards the project’s completion, all these factors must intertwine perfectly, otherwise the project’s success will be challenged. Uncovering how these intricacies are held in place has been the epistemological foundation of this boo

Neutrophil FcγRIIA availability is associated with disease activity in systemic lupus erythematosus

Background: Immune complexes (ICs) are detectable in a variety of inflammatory diseases, including systemic lupus erythematosus (SLE), reflecting autoantibody binding to antigens. Though ICs are the main contributors to disease pathogenesis through FcγR-mediated inflammation and organ damage, IC levels are not part of the clinical assessment of SLE. The aim of this study was to explore the clinica

Survival in 31 670 patients with thin melanomas : a Swedish population-based study

BACKGROUND: The incidence of cutaneous malignant melanoma (CMM) continues to increase in most countries worldwide and the majority are diagnosed with thin tumours (≤ 1 mm).OBJECTIVES: The aim of the present study was to investigate the melanoma-specific survival (MSS) as well as conditional MSS (CMSS) in patients with thin CMM in Sweden.PATIENTS AND METHODS: Clinical and histological parameters we

High-Sensitivity Assessment of Phagocytosis by Persistent Association-Based Normalization

Phagocytosis is measured as a functional outcome in many research fields, but accurate quantification can be challenging, with no robust method available for cross-laboratory reproducibility. In this study, we identified a simple, measurable parameter, persistent prey-phagocyte association, to use for normalization and dose-response analysis. We apply this in a straightforward analytical method, p

Why women do not use the helmet when riding a bicycle

Women seem to use the helmet when riding a bicycle less frequently than men. Two possible explanations for this behavior are that 1) it is less appalling to them because of lack of comfort or other reasons, or 2) they use bicycles in a more cautious way than men so they feel that they do not need the helmet as much. The present paper explores these two explanations in 5, 691 cyclists that responde

A perceptual approach to EU public diplomacy : Investigating collaborative diplomacy in EU-Ukraine relations

This article contributes to the theorisation of collaborative public diplomacy by introducing a perceptual approach. Engaging with the collaborative diplomacy paradigm developed to conceptualise public diplomacy in the context of non-traditional security threats and conflicts, as well as nation building, the article explores and compares perceptions of the European Union (EU) as a public diplomacy

Evaluation of TMPA satellite precipitation in driving VIC hydrological model over the upper Yangtze river basin

Although the Tropical Rainfall Measurement Mission (TRMM) has come to an end, the evaluation of TRMM satellite precipitation is still of great significance for the improvement of the Global Precipitation Measurement (GPM). In this paper, the hydrological utility of TRMM Multi-satellite Precipitation Analysis (TMPA) 3B42 RTV7/V7 precipitation products was evaluated using the variable infiltration c

The association between decision-making skills and subjective decision outcomes among administrative officers in the Swedish Social Insurance Agency

Social insurance administrative officers’ decision-making skills influence their efficiency at work and their general well-being. At work their tasks are characterised by complexity and a need for order and accountability. Moreover, cases should usually be handled and finalised within the imposed time frames. We investigated skills related to decision-making success among social insurance officers

Predictors of multiglandular disease in primary hyperparathyroidism

Background: Primary hyperparathyroidism (pHPT) is caused by single- or multiglandular disease (MGD). Patients with MGD have an increased risk of complications at surgery and for persistence and recurrence after surgery. The study evaluated whether preoperative clinical and biochemical characteristics could predict MGD in patients with pHPT. Methods: We retrospectively evaluated patients operated 1

Immune checkpoint inhibitors of the PD-1/PD-L1-axis in non-small cell lung cancer : promise, controversies and ambiguities in the novel treatment paradigm

Immune checkpoint inhibitors (ICIs) have received much attention not least for melanoma since the award of the Nobel prize in 2018. Here, we review the current state of knowledge about the use of these monoclonal antibodies (mAbs) in non-small cell lung cancer (NSCLC). These drugs have generally been conditionally approved on limited early data and there are few long-term follow-up data from rando