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Antibodies are important proteins participating in a number of reactions to protect us from harmful diseases. Apart from this important function, they are also useful in different technical and medical applications. This, however, relies on our possibility to produce antibodies in vitro. In the first part of my thesis a new technology called CDR shuffling was developed to create diverse and highly
Popular Abstract in Swedish Användningen av konstgjorda material för temporärt och permanent bruk, t.ex katetrar, skruvar, ledproteser är numera väl etablerad inom human- medicinen. Dessa sk biomaterial kan emellertid predisponera till proppbildning, inflammatoriska vävnadsreaktioner och infektioner i omgivande vävnad, ledande till svåra komplikationer, såsom blod- förgiftning, passagestopp samt pResident skin micro-organisms such as S. epidermidis and other coagulase-negative staphylococci (CoNS), are by far the most common causes of biomaterial-associated infections. These micro-organisms often exhibit surface adhesins that specifically bind serum and tissue proteins adsorbed to implanted biomaterials. The aim of this study was to extend our knowledge about such adhesins produced by CoNS
Eukaryotic cells possess sensitive systems for the detection of microbes and microbial-derived products. Bacteria-eukaryotic cells contact triggers several signaling pathways, most of which are dependent on protein-protein interactions followed by phosphorylation, leading to activation of defense mechanisms. Yersinia bacteria have evolved different strategies to interfere with eukaryotic host defe
In this paper we discuss parallelization and distribution of problems modeled in a constraint programming (CP) framework. We focus on parallelization of depth-first search methods, since search is the most time-consuming task in CP. The current hardware development is moving towards multi-core processors and the cost of building distributed systems is shrinking. Hence, parallelization and distribu
This paper describes a system to create animated 3D scenes of car accidents from reports written in Swedish. The system has been developed using news reports of varying size and complexity. The text-to-scene conversion process consists of two stages. An information extraction module creates a structured representation of the accident and a visual simulator generates and animates the scene. We firs
Although bone marrow (BM) represents the main site for postnatal NK cell development, recently a distinct thymic-dependent NK cell pathway was identified. These studies were designed to investigate the role of cytokines in regulation of thymic NK cells and to compare with established regulatory pathways of BM-dependent NK cell compartment. The common cytokine receptor gamma-chain (Il2rg) essential
Abstract in UndeterminedDifferential in-gel electrophoresis (DIGE) experiments allow three protein samples to be run per gel. The three samples are labeled with the spectrally resolvable fluorescent dyes, Cy2, Cy3, and Cy5, respectively. Here, we show that protein-specific dye effects exist, and we present a linear mixed model for analysis of DIGE data which takes dye effects into account. A Java
A searchable database of speech samples from more than 100 Swedish dialects is being established for use in research and education. Each dialect is represented by at least 12 speakers. Recordings are made of spontaneous speech as well as words and phrases elicited with a number of specific research goals in mind. This paper summarizes one of these goals, a prosodic typology for the Swedish dialect
We have discovered four extremely surprising emission lines of strontiumin ejecta near eta Carinae. Hubble Space Telescope (HST) SpaceTelescope Imaging Spectrograph (STIS) observations made in 1999 show twonarrow features whose wavelengths correspond to the forbiddentransitions of Sr II, and we have found no other plausibleidentification for these lines. The identifications are confirmed by newHST
We present the results of realistic N-body modelling of massive star clusters in the Magellanic Clouds, aimed at investigating a dynamical origin for the radius-age trend observed in these systems. We find that stellar-mass black holes, formed in the supernova explosions of the most massive cluster stars, can constitute a dynamically important population. If a significant ensemble is retained (her
Popular Abstract in Swedish En av de stora vetenskapliga bedrifterna hittills under 2000-talet är onekligen att man efter många års arbete för första gången lyckades kartlägga (sekvensera) samtliga mänskliga gener. Det mänskliga DNA:t är lokaliserat till cellkärnan och i princip så kan man likna en cellkärna med ett kontrollrum fyllt av manualer (DNA) som talar om cellens sammansättning och hur deProteomics is expected to generate new insights into biological processes as well as identify novel biomarkers and therapeutic targets since most biological functions are transmitted through proteins. However, due to the complexity displayed by a proteome and inherent limitations associated with current methodologies, proteomic analyses often result in incomplete coverage and inconsistent measurem
In this paper we present a new method for high-level synthesis that enhances design flexibility, specialization and performance primarily conceived for programmable hardware. New programmable hardware devices often provide fast dedicated components that perform complex computations. Arbitrary complex computations can be efficiently extracted from the CDFG using our new graph matching constraint to
