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Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid

Uronate isomerase (EC 5.3.1.12; URI) catalyzes uronate sugar interconversion, a key step in bacterial metabolism, yet its reaction mechanism remains poorly understood. This study delineates the detailed mechanism for the isomerization of d-glucuronate to d-fructuronate catalyzed by a Zn2+-dependent URI enzyme (from Bacillus halodurans). Using quantum mechanical (QM) cluster calculations, three mec

This paper examines firefighter exposure to emissions during actual firefighting in building scenarios. The focus is on actual exposure, not small-scale lab tests, to identify research gaps in light of the International Agency for Research on Cancer (IARC) classification of firefighting as an occupation with a heightened risk for certain types of cancer. The work is based on a systematic literatur

Bekämpningen av penningtvätt utgör ett centralt samhällsintresse inom Europeiska unionen och har gett upphov till ett omfattande regelverk som ställer långtgående krav på att verksamhetsutövare behandlar och lagrar personuppgifter. Samtidigt har skyddet för den personliga integriteten stärkts genom EU:s allmänna dataskyddsförordning (GDPR). Regelverken är inte direkt motstridiga, men förutsätter eThe fight against money laundering constitutes a central public interest within the European Union and has resulted in an extensive regulatory framework imposing far-reaching obligations on obliged entities to process and retain personal data. At the same time, the protection of personal privacy has been strengthened through the EU General Data Protection Regulation (GDPR). Although these regulato

The Bible appears regularly in Margaret Atwood’s novels, from The Edible Woman in 1969 to The Testaments in 2019. Atwood’s characters do not tend to be religious, but like most people in the Western world, they encounter the Bible in schools, at funerals, in headlines, advertisements, and occasionally from religious people themselves. Atwood’s Bible is a Christian Bible, the references running fro

INTRODUCTION: Many depressed patients do not achieve remission with available treatments. Anhedonia is a common residual symptom associated with treatment resistance as well as low function and quality of life. There are currently no specific and effective treatments for anhedonia. Some trials have shown that dopamine agonist pramipexole is efficacious for treating depression, but more data is nee

Arrhythmogenic right ventricular cardiomyopathy (ARVC) and cardiac sarcoidosis (CS) can show significant overlap in their clinical presentation. Differentiation between both is crucial for optimal patient management. Aim of this study is to develop an ECG-based machine learning model to distinguish between ARCV and CS patients. The study population included 100 patients (50 with ARCV and 50 with C

Objective: Both auditory and visual hypersensitivity are clinical features of mental fatigue after acquired brain damage or in neurological disorders. Both types of hypersensitivity are also associated with attention deficits, especially in neurodevelopmental syndromes. The aim of this study was to examine auditory and visual hypersensitivity, and associations to attention, in a group of children

The dynamical evolution of globular clusters (GCs) is tied to their binary population, as binaries segregate to the cluster centre, leading to an increased binary fraction in the core. This central overabundance of mainly hard binaries can serve as a source of energy for the cluster and has a significant effect on the observed kinematics, such as artificially increasing the observed line-of-sight

We use direct N-body simulations to explore some possible scenarios for the future evolution of two massive clusters observed towards the centre of NGC 4654, a spiral galaxy with mass similar to that of the Milky Way. Using archival HST data, we obtain the photometric masses of the two clusters, M = 3 × 105 M= and M = 1.7 × 106 M=, their half-light radii, Reff ∼4 pc and Reff ∼6 pc, and their proje

Cities, and more importantly urban neighborhoods, are key sites of infrastructure provision with direct links to social and environmental concerns. They are increasingly seen as sites of strategic action in transitions toward sustainability and resilience, and offer big opportunities for fundamental societal change. The framing of neighborhood-level problems and their solutions, governance process

The analysis of surface wave dispersion curves is a way to infer the vertical distribution of shear wave velocity. The range of applicability is extremely wide: going, for example, from seismological studies to geotechnical characterizations and exploration geophysics. However, the inversion of the dispersion curves is severely ill-posed and only limited efforts have been put in the development of

Background: Ascending aortic dilation is a feared complication in adults with repaired coarctation of the aorta, as the condition is associated with life-threatening complications such as aortic dissection and rupture. However, the data are currently limited regarding factors associated with ascending aortic dilation in these patients. Methods and results: From the national register of congenital

With the advancement in autonomous driving technology, the shape of vehicle seats is expected to change. Against this backdrop, a study is required to verify whether or not the diversely-changing seat arrangements are appropriate from the emotional perspective of the driver. This study set the first-row passenger scat with an adjustable seatback, such as an upright position, a 15-degree rotation,

For many years, fascism in East Central and Southeastern Europe remained an overlooked aspect of the history of transnational and transatlantic fascism. This introduction provides a background on how this came to pass and why we should rethink this assumption. The introduction explains how the heterogeneity of East Central and Southeastern European fascism alters the general understanding of Europ