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The overall aims of this thesis were to improve prediction, diagnostics and knowledge on epidemiology of sepsis. In paper I, we developed and evaluated an integrated platform for rapid analysis of sepsis-causing organisms directly from blood samples. Testing with blood samples spiked with bacteria and samples from septic patients indicate that the detection limit of the system is in the upper part
Circular oriented innovation commonly requires collaboration. Yet, to date, circular research lacks empirical investigation into collaborative processes. Collaborative processes are, however, highly researched within strategic management literature, thus offering valuable insights. The purpose of this paper is to investigate, identify and order the processes that companies undertake when designing
Charged Higgs boson production in association with a top quark could be the first indication of the existence of Higgs particles. The Tevatron Run-II started data-taking in April 2001 at √s = 1960 GeV and could probe the existence of a charged Higgs boson beyond the current mass limit. We study the pp̄ → tbH± production process with Monte Carlo simulations in HERWIG and PYTHIA, comparing expected
In September of 2017, the Swedish government introduced a proposal for a new Consultation Act that would require the government and other state agencies to consult with the indigenous Sami people on issues of importance to them. The aim of the proposed law is to strengthen and promote the influence of the Sami people over their own affairs. This thesis analyses whether the proposal is in line with
There is a need to develop new techniques for quantitative measurement of receptors expression on particular vasculature cells types. Here, we describe and demonstrate a novel method to measure quantitatively and simultaneously the expression of endothelin B receptor (ETB) on vascular smooth muscle cells (VSMC). We isolated cells from male rat tissues such as: brain pial, brain intraparenchymal an
Popular Abstract in Swedish Inom processanalytisk kemi är uppgiften att bestämma viktiga egenskaper i en kemisk process under det att tillverkningen fortlöper. Ett vanligt exempel är att man bestämmer halten av något ämne. Eftersom de uppmätta egenskaperna ofta används för att styra processandet mot bästa möjliga betingelser är det av generellt intresse att mätningen går snabbt. Men det är inte noPharmaceutical tablets and pellets are often covered with a coating. There is a need for methods that enable monitoring of the growth of such films during processing. Such analyses can be performed using process analytical chemical methods based on near infrared (NIR) diffuse reflectance spectrometry. It provides with analyses that take only ca. 8 seconds in total analysis time, including physical
The aim of this thesis was by a comparative study investigate the small Roman bust found in Västra Vång to increase the understanding of the context is which it was created. The comparative study was leaning on two hypotheses; that the bust was depicted with a so-called melon coiffure and that the bust was a depiction of a barbarian. Two catalogues was created on the basis of these hypotheses to b
The synergistic relation between nutritional deficiency and infection may have negative effects on the immune system, making individuals more vulnerable to infection. Zinc can affect the resistance to infections by modulating cytokine release, and by acting as a cofactor of thymulin, which induces the differentiation of immature T lymphocytes. To investigate the modulation of the immune response b
This paper presents a model-based method to aid in the process validation for the purification of pharmaceutical drugs. The critical process parameters are identified by simulating process disturbances, and this information is then used to determine if the process control space is robust. Simulations are chosen to analyze the entire control space to also find nonlinearities and interaction effects
In view of global climate change and the increasing energy demand there is a need for renewable energy resources. This thesis discusses an energy-driven biorefinery concept based on the agricultural residues corn stover and wheat straw. The work is divided into two main parts. The first part is concerned with the effects of steam pretreatment and choice of acid catalyst on ethanol and biogas produ
By regulating migration, proliferation and apoptosis as well as extracellular matrix synthesis and assembly, proteoglycans, integrins and the dystrophin-glycoprotein complex may be of great importance both during development and in vascular disease.
John Maynard Keynes became world famous with the publication of The Economic Consequences of the Peace in 1919, a harsh critique of the Versailles peace treaty. As a consequence, Keynes was nominated by German professors in economics for the Nobel Peace Prize three years in a row, 1922, 1923 and 1924. Because Keynes was put on the shortlist of candidates, he was evaluated in an advisory report in
