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The selectivity of preparations of α-chymotrypsin immobilized on Celite or polyamide and carrying out syntheses of di- and tripeptides in acetonitrile medium were studied. The study concerns the effect of mass- transfer limitations on three different kinds of selectivity: acyl donor, stereo- and nucleophile selectivities, defined respectively as the ratio of initial rates with different acyl donor
Background: Can we validate a contagion model for drug abuse (DA) in Propinquity-of-Rearing Defined Acquaintances (PRDAs)? Methods: PRDAs were defined as pairs of same-age males born 1975–1990 who grew up within 2 km of each other, one of whom (PRDA1) being first registered for DA in national registries. Using adult residential location, we predicted, using regression splines, proximity-dependent
Global society is rapidly ageing. Research on ageing and mobility suggests that better synergies could exist between older people and the built environment. The age-in-place policy will put increased demands on the transport system as a key facilitator for access. The main goal of this study is to examine the spatial distribution of older adults, assessing if it could be affected by selective char
BackgroundDense Non Aqueous Phase Liquids (DNAPL) such as chlorinated solvents are common pollutants stemming from different types of industries including dry cleaning facilities, and reports on cases showing serious risk to soil and ground water are frequent on a global scale. DNAPLs are especially problematic as they are denser than water and move down through the groundwater, not always followi
Open Innovation (OI) has gained significant attention since the term was introduced in 2003. However, little is known whether general software testing processes are well suited for OI. An exploratory case study on the Acceptance Test Harness (ATH) is conducted to investigate OI testing activities of Jenkins. As far as the research methodology is concerned, we extracted the change log data of ATH f
Understanding land use and land cover (LULC) change through time is an important aspect when attempting to interpret human-environment interactions through time. Palaeoenvironmental techniques have been crucial in bridging this gap by providing information that has been used to estimate climate change, vegetation change, sea level change etc. through time using a variety of proxies. Producing quan
Global gridded crop models (GGCMs) combine agronomic or plant growth models with gridded spatial input data to estimate spatially explicit crop yields and agricultural externalities at the global scale. Differences in GGCM outputs arise from the use of different biophysical models, setups, and input data. GGCM ensembles are frequently employed to bracket uncertainties in impact studies without inv
Introduction: Multiple myeloma (MM) is a plasma cell neoplasm with substantial morbidity and mortality. A comprehensive description of the global burden of MM is needed to help direct health policy, resource allocation, research, and patient care.Objective: To describe the burden of MM and the availability of effective therapies for 21 world regions and 195 countries and territories from 1990 to 2
Background: Venous thromboembolism (VTE) is the third most frequent life-threatening cardiovascular disease with an annual incidence rate of 1-2 per 1000 person-years. After the diagnosis for primary VTE, about 20-30% patients develop a recurrence within 5-years. VTE recurrence can be prevented by anticoagulants, albeit at the risk of severe bleeding. Heritability of VTE is high and hereditary fac
Introduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols. Methods: This systematic review summarizes the current literature on the influence of preanalytical variables on CSF biomarker concentration. We evaluated the evidence for three core CSF biomarkers:
Fifty-one half-sib families with 2768 sires were selected for this study to confirm a quantitative trait locus (QTL) detected within a previous project initiated by the German Cattle Breeders Federation (ADR). The data based on a granddaughter design were divided into two parts and were analysed using linear models and paternal half sib regression methods. The results strongly support the hypothes
A search is presented for the direct pair production of the stop, the supersymmetric partner of the top quark, that decays through an R-parity-violating coupling to a final state with two leptons and two jets, at least one of which is identified as a b-jet. The data set corresponds to an integrated luminosity of 36.1 fb-1 of proton-proton collisions at a center-of-mass energy of √s= 13 TeV, collec
RESEARCH DESIGN AND METHODS: We studied participants in PROVALID (PROspective cohort study in patients with type 2 diabetes mellitus for VALIDation of biomarkers), a prospective multinational cohort study of patients with type 2 diabetes and a follow-up of more than 24 months (n = 2,560; baseline median eGFR, 84 mL/min/1.73 m2; urine albumin-to-creatinine ratio, 8.1 mg/g). The 17 biomarkers were m
Introduction: The thrombin generation assay-calibrated automated thrombogram (TGA-CAT) method is used to measure the overall coagulation capacity in plasma. However, the method is still considered to be a research tool, mainly because of its’ lack of standardization. Aim: Our study aimed to further raise the standardization level for the TGA-CAT method by evaluating a detailed standardization prot
Recent climate warming has altered plant phenology at northern European latitudes, but conclusions regarding the spatial patterns of phenological change and relationships with climate are still challenging as quantitative estimates are strongly diverging. To generate consistent estimates of broad-scale spatially continuous spring plant phen
Dynamic global vegetation models are a common tool to assess the effect of climate and land use change on vegetation. Though most applications of dynamic global vegetation models use plant functional types, some also simulate species occurrences. While the current development aims to include more processes, e.g. the nitrogen cycle, the models still typically assume an ample seed supply allowing al
Background Risk factors included in the cardiovascular (CHA2DS2‐VASc) score, currently used for atrial fibrillation (AF), may predispose to cardiovascular events whether or not AF is present. The aim was to explore the predictive role of CHA2DS2‐VASc score on cardiovascular outcomes in diabetic patients without AF. Methods We accessed individual data from 610 diabetic patients without AF at baseli
A search for heavy long-lived multicharged particles is performed using the ATLAS detector at the LHC. Data with an integrated luminosity of 36.1 fb-1 collected in 2015 and 2016 from proton-proton collisions at s=13 TeV are examined. Particles producing anomalously high ionization, consistent with long-lived massive particles with electric charges from |q|=2e to |q|=7e, are searched for. No events
