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Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemis
Background: Growing up with congenital heart disease (CHD) often means transfer to adult care and lifelong medical follow-up. An optimal transition process usually involves a multipart collaboration between the patient, their parents and other family members, and the healthcare providers. Taking an active role while knowing when it is time to step aside can be difficult for all the concerned parti
Rationale: Several guidelines exist that address treatment of patients with nonmetastatic muscle-invasive bladder cancer (MIBC). However, most only briefly mention follow-up strategies for patients and hence the treating physician is often left to infer on what the preferred follow-up schema would be for an individual patient. Herein, we aim to synthesize recommendations for follow-up of patients
The advent of novel agents for multiple myeloma (MM) is cause for a re-examination of the incidence of second primary malignancies (SPMs). We examined the SPM rate in MM patients who were enrolled in the prospective observational CALM (Collaboration to Collect Autologous Transplant outcome in Lymphoma and Myeloma) study. Between 2008 and 2012, 3204 patients with MM underwent a first autologous hem
Designing high-rise buildings is a complex and challenging task involving several parameters and variables. Recently, there have been major attempts to design the overall form of these buildings based on optimization approaches. This paper introduces a multi-objective optimization framework based on Genetic Algorithm, namely Energy Efficient Form-finder (EEF), consisting of four main steps of Form
Atrial fibrillation (AF) is a common disease with a high prevalence in the adult population. Treatment of AF encompasses antiarrhythmic drugs and catheter ablation to reduce symptoms. The aim of this thesis was to study how to best alleviate symptoms of AF in a safe and efficient way comparing pharmacological treatment and the two dominating catheter ablation techniques, cryoballoon (CRYO) ablatio
Prostate cancer (PCa)is one of the first three causes of cancer mortality in Europe. Screening in asymptomatic men (aged 55–69 yr)using prostate-specific antigen (PSA)is associated with a migration toward lower staged disease and a reduction in cancer-specific mortality. By 20 yr after testing, around 100 men need to be screened to prevent one PCa death. While this ratio is smaller than for breast
The selectivity of preparations of α-chymotrypsin immobilized on Celite or polyamide and carrying out syntheses of di- and tripeptides in acetonitrile medium were studied. The study concerns the effect of mass- transfer limitations on three different kinds of selectivity: acyl donor, stereo- and nucleophile selectivities, defined respectively as the ratio of initial rates with different acyl donor
Background: Can we validate a contagion model for drug abuse (DA) in Propinquity-of-Rearing Defined Acquaintances (PRDAs)? Methods: PRDAs were defined as pairs of same-age males born 1975–1990 who grew up within 2 km of each other, one of whom (PRDA1) being first registered for DA in national registries. Using adult residential location, we predicted, using regression splines, proximity-dependent
BackgroundDense Non Aqueous Phase Liquids (DNAPL) such as chlorinated solvents are common pollutants stemming from different types of industries including dry cleaning facilities, and reports on cases showing serious risk to soil and ground water are frequent on a global scale. DNAPLs are especially problematic as they are denser than water and move down through the groundwater, not always followi
The invention is directed to a method of increasing the chemical and/or thermal stability of PHA in biomass where the biomass is contained within mixed liquor, and wherein the mixed liquor is treated by a combination of removing water from the mixed liquor and pH adjustment of the mixed liquor or maintenance of the pH of the mixed liquor within a selected pH range, and wherein the method includes
A chaos expanded Fourier split-step method is derived and applied to a narrow-angle parabolic equation. The parabolic equation has earlier been used to study deterministic settings. In this paper we develop a spectral-based Fourier split-step method that will take a limited degree of information about the environment into account. Our main focus is on proposing an efficient method for computationa
Background: The causes and effects of anastomotic leakage after anterior resection are difficult to study in small samples and have thus been evaluated using large population-based national registries. To assess the accuracy of such research, registries should be validated continuously. Material and methods: Patients who underwent anterior resection for rectal cancer during 2007–2013 in 15 differe
The large rate of multiple simultaneous proton–proton interactions, or pile-up, generated by the Large Hadron Collider in Run 1 required the development of many new techniques to mitigate the adverse effects of these conditions. This paper describes the methods employed in the ATLAS experiment to correct for the impact of pile-up on jet energy and jet shapes, and for the presence of spurious addit
