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Background: Can we validate a contagion model for drug abuse (DA) in Propinquity-of-Rearing Defined Acquaintances (PRDAs)? Methods: PRDAs were defined as pairs of same-age males born 1975–1990 who grew up within 2 km of each other, one of whom (PRDA1) being first registered for DA in national registries. Using adult residential location, we predicted, using regression splines, proximity-dependent

Global society is rapidly ageing. Research on ageing and mobility suggests that better synergies could exist between older people and the built environment. The age-in-place policy will put increased demands on the transport system as a key facilitator for access. The main goal of this study is to examine the spatial distribution of older adults, assessing if it could be affected by selective char

Sustainable development was defined by the Bruntland Comission as a 'development that meets the needs of the present without compromising the ability of future generations to meet their own needs' (WCED1 , 1987, p. 8). In the report 'Our Common Future' the Bruntland Commission proposed policies for a 'World Programme for Change' (WCED, 1987). At the UNCED2 , conference in Rio 1992, proposals were

This paper examines forest-based bioeconomy innovation in Sweden between 1970 and 2021 to test central claims about innovation complexity, knowledge requirements, collaboration intensity, and industrial life cycle dynamics. Using a comprehensive database of 4,972 commercialized innovations, I identify 649 forest bioeconomy innovations and analyze their characteristics through logistic regression,

Simulation methods in breast imaging offer advantages over clinical trials in terms of improved reproducibility, reduced need for patient exposure to radiation, increased flexibility, and more clearly defined ground truth. Simulation also allows for improved representation of anatomical variations and variations in acquisition parameters and breast positioning related to multimodality imaging. The

Objective: In the present study, we investigated the role of the gut–liver crosstalk in the pathogenesis of steatotic liver disease (SLD) induced by the compounding and deleterious effects of alcohol and metabolic risk factors, and explored the potential translational aspects of microbiome-based interventions. Design: The effects of combined exposure to alcohol and a high-fat, high-cholesterol die

BACKGROUND: Iron deficiency is the most common micronutrient deficiency worldwide, negatively affecting quality of life and health. Young women are at particularly high risk due to increased iron demands during growth, menstrual blood losses, and dietary habits. There are no official guidelines recommending screening for iron deficiency in healthy young women. This study aimed to develop a screeni

In humans, a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of β-cells, with healthy vo

In this study, we perform paleontological and sedimentary research of three sections, Tianjiayuanzi, Jiulongwan, and Qinglinkou, located within the carbonate platform of the Huangling Anticline in the eastern Three Gorges area, Yichang City, Hubei Province. The aim is to investigate the spatial distribution patterns of microfossils in silicified bands from the lower Member III of the Doushantuo Fo

Adjuvant treatment of nonmetastatic high-risk renal cell carcinoma is an unmet medical need. In the past, several tyrosine kinase inhibitor trials have failed to demonstrate an improvement of disease-free survival (DFS) in this setting. Only one trial (S-TRAC) provided evidence for improved DFS with sunitinib but without an overall survival (OS) signal. Keynote-564 is the first trial of an immune

This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of t

A measurement of the Higgs boson production cross sections via associated WH and ZH production using H→WW⁎→ℓνℓν decays, where ℓ stands for either an electron or a muon, is presented. Results for combined WH and ZH production are also presented. The analysis uses events produced in proton–proton collisions collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The data cor

Purpose: Air monitoring has been the accepted exposure assessment of toxic metals from, e.g., welding, but a method characterizing the actual dose delivered to the lungs would be preferable. Sampling of particles in exhaled breath can be used for the biomonitoring of both endogenous biomarkers and markers of exposure. We have explored a new method for the sampling of metals in exhaled breath from

Contaminated sites constitute a global problem as they pollute important freshwater systems at a local scale. To effectively address these sites for remediaton, we must first characterize the sites in order to gain an understanding of the geological setting. This step is crucial as it helps determine groundwater flow pathways and the dynamics of surface water-groundwater exchange within these syst

The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effe

This article takes the awarding of William B. Gartner as a winner of the FSF-Nutek Award (in 2005) as a reason to engage more thoroughly with his production. From the perspective of a European School of Entrepreneurship, we focus in particular on the hermeneutic/phenomenological side of Gartner's research output and seek to operate as inspired readers of this work as we identify its central tenden

Background: Advances in treatment of childhood malignancies have improved overall cure rates to 80%. Nevertheless, cancer is still the most common cause of childhood mortality in Sweden. The prognosis is particularly poor for relapse of high-risk malignancies. In the international INFORM registry, tumor tissue from patients with relapsed, refractory, or progressive pediatric cancer as well as from

The CP properties of the coupling between the Higgs boson and the top quark are investigated using 139 fb−1 of proton–proton collision data recorded by the ATLAS experiment at the LHC at a centre-of-mass energy of s=13 TeV. The CP structure of the top quark–Higgs boson Yukawa coupling is probed in events with a Higgs boson decaying into a pair of b-quarks and produced in association with either a