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Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized by aggregation of proteins with expanded polyglutamine (polyQ) tracts. The mechanism of aggregation involves primary and secondary nucleation steps. We show how a noncanonical member of the DNAJ-chaperone family, DNAJB6, inhibits the conversion of soluble polyQ peptides into amyloid fibrils, in particular by suppre
This article makes a contribution to the critique of market-based mechanisms for climate and energy policy. It explores the environmental effectiveness of market instruments by engaging a broadly conceived “fossil fuel landscape”, or the material, social, and political inertia of fossil energy dependence, as a factor delimiting policy outcomes. The argument is developed through a focus on the idea
Walkability is often researched from the perspective of certain physical features in the built environment. However, for this paper, the point of departure was to also treat walking as a transport mode for reaching destinations and performing every-day activities. A conceptual model addressing both perceptions of the built environment and perceived limits due to every-day activities was used as a
Recent decades have been characterised by increasingly complex governance structures. In order to tackle threats from epidemics, environmental degradation and other trans-boundary problems governments collaborate not only with actors from other governments, international agencies and civil society, but also from the private sector and business community. Large numbers of global partnerships, inclu
In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer
Characterization of the glomerular filtration barrier is of fundamental importance for understanding the pathophysiology of proteinuric kidney diseases. Furthermore, it can be of key value in the understanding of microalbuminuria, which is often associated with endothelial dysfunction in conjunction with cardiovascular disease. In the four studies of this doctoral thesis, macromolecular probes hav
Deep-inelastic positron-proton scattering events at low photon virtuality, Q(2), with a forward jet, produced at small angles with respect to the proton beam, are measured with the H1 detector at HERA. A subsample of events with an additional jet in the central region is also studied. For both samples, differential cross sections and normalised distributions are measured as a function of the azimu
This case study aims to dissect the world famous Wenzhou footwear manufacturing industry in order to discover how, if at all, the case complies with an industrial organisation framework, namely the industrial district model, which is becoming more and more prevalent in less developed countries (LDCs). In order to examine the extent to which the industrial district model may have developed and adv
Abstract: In this Master's thesis, the Bush administration's ?war on terrorism? is examined. Taking a discursive approach, the study seeks to explicate how the ?war on terror? has been linked to the concept of identity and ultimately to cast light on the problematic implications of the discourse. A fundamental aim in this regard has been to address a recent US intelligence report whose fi
Introduction: Enhancing Quality of Life for Individuals with Stroke (EQL-stroke) is an international, collaborative multiphase project aiming to strengthen supported self-management for older adults recovering from stroke at home in Sweden, Latvia and the Netherlands. Existing poststroke pathways may provide insufficient support for self-management during the transition from hospital to home, and
When discussing nation branding, there are three perspectives that correlate with each other: National Identity, Nation Brand Identity and Nation Brand Image. This thesis explores the nation branding of Sweden, and describe the three perspectives with a focus on Sweden. When comparing how the perspectives are comported with each other, there is the possibility of gaps existing when one perspective
In this text the author attempts to extract the criteria for establishing ''overall control'' as described by the Appeals Chamber of the International Criminal Tribunal for the Former Yugoslavia in the case against Dusko Tadic. This test was formulated by the ICTY Appeals Chamber in an effort to qualify the relationship between the Federal Republic of Yugoslavia and the army of the
Agila avtal är ett förhållandevis nytt fenomen och uppmärksammat begrepp. Fenomenet härstammar ursprungligen från ett agilt arbetssätt, som är särskilt utbrett inom IT-branschen. Traditionella avtal är upprättade utifrån förutsättningen att parterna redan vid avtalstillfället vet vad som ska levereras, när och hur. Det uppställs en uttömmande kravspecifikation vid projektets början. I ett agilt Agile contracts are a relatively new phenomenon that has gained increased recognition. This phenomenon originates from an agile approach, which is particularly widespread in the IT industry. Traditional contracts are based on a situation where the parties know what they need before the project starts. The requirements are set out comprehensively at the outset of the project. In an agile contract,
The European Union (EU) in its current shape and form is primarily a product of deepening economic integration, whereas a social dimension of European integration that would be comparable in ambition to its economic dimension has failed to manifest itself despite repeated attempts to give the social dimension greater weight. Based on a neo-Gramscian theoretical perspective of hegemony, this can be
The collective identity is under permanent negotiation. Due to the lack of incentive to offer public communication, the collective identity of Japanese bureaucrats; kanryo(官僚) has been constructed separately inside and outside of ministries. Firstly, I explore how the collective identity of kanryo has been constructed in two Japanese national newspapers. Also, the constructed identity of kanryo wi
Svampmycelet formas efter miljön Ett svampmycel är en komplex vegetativ enhet som påverkas av miljöfaktorer som till exempel näringstillgång. Detta är känt hos högre, frilevande, svampar som lever av döda växtdelar. Min studie visar att även svampar som lever i symbios med växter, utvecklar sitt mycel i direkt respons till omgivningen. Svampar har olika sätt att överleva. Svampen kan leva som sapAbstract The mycelium formation and foraging strategies of arbuscular mycorrhizal fungi (AMF) are not well understood, due to the biotrophic nature of these fungi, which makes cultivation methods without a host difficult. However, in-vitro-techniques have been developed in which AMF are inoculated on genetically transformed roots of various dicotyledonous plants. In the present study, monoxenic c
With the new information society and knowledge economy evolve different and more complex requirements to innovation and competitiveness. Scholars and policy makers have emphasized the importance of adapting to ICT and exploit its numerous possibilities, although the exact methods for doing so remain unclear. The integration of ICT in educational institutions and their curricula have been stressed
Svaga riktlinjer utan verkan? Sedan vi människor började bruka jorden för mer än 10 000 år sedan, har vi haft nytta av humlor och bin som pollinerat våra grödor och spindlar och skalbaggar som ätit upp skadeinsekter som t.ex. bladlöss. Dessa och många andra så kallade ekosystemtjänster riskerar nu att försvinna allteftersom människan gör anspråk på större och större ytor och brukar jorden allt inAbstract Biodiversity continues to decline worldwide and this is threatening the provisioning of ecosystem services. The EU has a target of halting the loss of biodiversity and the degradation of ecosystem services in the union by the year 2020. In the reformed Common Agricultural Policy that will take effect in the EU in 2014, three greening measures are included to meet the reform objectives fo
The aim of this study is to investigate the current leadership style and the organisational climate at the LFV in Sturup. To assess the leadership style the Multifactor Leadership Questionnaire (MLQ) by Bass (1985) was used. The organisational climate was measured with the GEFA developed by Ekvall (1986). The participants of the survey were employees from all departments of the airport, but no lea
