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Background: The optimal timing of anticoagulation for patients with acute ischaemic stoke with atrial fibrillation is uncertain. We investigated the efficacy and safety of early compared with delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischaemic stroke associated with atrial fibrillation. Methods: We performed a multicentre, open-label, blinded-endpoint, paralle

Preeclampsia (PE) is a pregnancy disorder characterized by systemic endothelial damage that leads to long-term cardiovascular complications. The endothelial glycocalyx (EG) covers the luminal surface of endothelium playing a critical role in vascular homeostasis. In this study we aimed to evaluate EG thickness and blood pressure (BP) trends in women with a history of PE vs. normotensive pregnancy.

Purpose - The dimple is adopted into a pin fin wedge duct which is widely used in modern gas turbine vane cooling structure trailing edge region. The purpose of this paper is to study the effects of dimple depth and duct converging angle on the endwall heat transfer and friction factor in this pin fin wedge duct. Design/methodology/approach - The study is carried out by using the numerical simulat

Public debt soared in the late-medieval Low Countries: towns borrowed considerable sums from creditors and often ended up defaulting on their financial obligations. The author uses a tax inquiry from 1514 to demonstrate that villages also managed to create funded debt, which they secured on the public body of the village. As a result, around 1500 the majority of the villages in Holland owed annuit

The Internet allows people to freely navigate through news and use that information to reinforce or support their own beliefs in, for example, different social networks. In this chapter we suggest that the representation of current predominant views in the news can be seen as collective expressions within a society. Seeing that the notion of what makes individuals happy has been of increasing inte

BACKGROUND: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study,

Astaxanthin (AXT) is a reference model of xanthophyll carotenoids, which is used in medicine and food industry, and has potential applications in nanotechnology. Because of its importance, there is a great interest in understanding its molecular properties and aggregation mechanism in water and mixed solvents. In this paper, we report a novel model of AXT for molecular dynamics simulation. The mod

When utilising archaeomagnetic data to constrain geomagnetic field models, uncertainties in inclination are often given as the angular standard deviation. This is a factor of √2 larger than the standard deviation of the marginal distribution of inclination and a number of recent studies have overestimated the sampling contribution to the error budget. More generally, the uncertainties in inclinati

Objective: Additional and comorbid diagnoses are common among suicide victims with major depressive disorder (MDD) and have been shown to increase the suicide risk. The aim of the present study was first, to investigate whether patients with severe depression/melancholia who had died by suicide showed more additional psychiatric disorders than a matched control group. Second, general rates of como

Background:Re-ablement is an approach aiming at improve home-care services for older people and to enable and support active engagement in everyday activities. An important responsibility for occupational therapists (OT) is to educate and support home care personnel, by coaching, mentoring and teaching them to work together with the clients to support their management of everyday activities as far

Thymic expression of insulin has been suggested to play a major role in negative selection of autoreactive T cells and tolerance induction against pancreatic beta cells. Furthermore, the expression of insulin in peripheral antigen-presenting cells (APC) has been clearly demonstrated but whether thymic negative selection and tolerance induction also depends on peripheral influx of self-antigens (Ag