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Objective: Although targeted approaches have become available in second- and third-line settings, platinum-based chemotherapy remains the standard first-line treatment for advanced muscle-invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance. Methods: In this study, we established a routine compatible method for the molecular classificati

Oat (Avena sativa L.) is an important and nutritious cereal crop, and there is a growing need to identify genes that contribute to improved oat varieties. Here we utilize a newly sequenced and annotated oat reference genome to locate and characterize quantitative trait loci (QTLs) affecting agronomic and grain-quality traits in five oat populations. We find strong and significant associations betw

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery.

An established negative association between socio-economic status (SES) and divorce has applied to most Western nations since 1960. We expected a positive association between SES and divorce for low-divorce contexts historically because only individuals in higher social strata had the resources to overcome barriers to divorce. According to Goode’s socio-economic growth theory, this relationship wa

Willingness to pay (WTP) for booster doses of coronavirus disease 2019 (COVID-19) vaccines is an under studied research topic. Therefore, the current study aimed to investigate the WTP for the booster doses of COVID-19 vaccines and its predictors in Indonesia using an online survey distributed all over the provinces of this low-middle-income country. The WTP was evaluated using a basic dichotomous

The upcoming Cherenkov Telescope Array (CTA) ground-based gamma-ray observatory will open up our view of the very high energy Universe, offering an improvement in sensitivity of 5-10 times that of previous experiments. NectarCAM is one of the proposed cameras for the Medium-Sized Telescopes (MST) which have been designed to cover the core energy range of CTA, from 100 GeV to 10 TeV. The final came

Background: Rectal washout (RW) is routinely performed during anterior resection (AR) for rectal cancer to reduce local recurrence (LR), although is sometimes not performed during minimally invasive surgery (MIS) procedures due to technical challenges and time consumption. The aim was to investigate the impact of RW on the oncological outcome after AR for rectal cancer in a registry cohort. Method

The potential of geothermal energy for energy transition is increasingly recognized by governments around the world. Whether geothermal energy is a sustainable source of heat and/or electricity depends on how it is deployed in specific contexts. Therefore, it is striking that there is only limited attention to geothermal energy from a social science and humanities (SSH) perspective. Geothermal ene

This paper presents a scoping review of methods for fire evacuation training in buildings. It adopts the PRISMA methodology (Transparent Reporting of systematic Reviews and Meta-Analyses) and systematically identifies 73 sources among scientific literature published between 1997 and 2022. It was found that the literature is dominated by research on modern technology (Augmented Reality, Virtual Rea

Tissue clearing is commonly used for whole-brain imaging but seldom used for brain slices. Here, we present a simple protocol to slice, immunostain, and clear sections of adult rat brains for subsequent high-resolution confocal imaging. The protocol does not require toxic reagents or specialized equipment. We also provide instructions for culturing of rat brain slices free floating on permeable cu

The spatial distribution of elemental abundances and their time evolution are among the major constraints to disentangling the scenarios of formation and evolution of the Galaxy. Aims. In this paper we used the sample of open clusters available in the final release of the Gaia-ESO survey to trace the Galactic radial abundance and abundance-to-iron ratio gradients, and their time evolution. Methods

The Soil and Water Assessment Tool (SWAT) model has been widely applied for simulating the water cycle and quantifying the influence of climate change and anthropogenic activities on hydrological processes. A major uncertainty of SWAT stems from the poor representation of vegetation dynamics due to the use of a simplistic vegetation growth and development module. Using long-term remote sensing-bas

This article examines positive obligations under the European Convention on Human Rights from the perspective of the level of concreteness chosen for their framing. This level is essential for understanding whether and how the analytical distinction between the existence of an obligation and the breach of this obligation can be applied. The level of concreteness is an important conceptual framew

This article considers the 2030 Agenda for Sustainable Development (United Na-tions 2015) and its 17 Sustainable Development Goals (SDGs) in relation to musiceducation and specifically small-group instrumental teaching. Sweden ranks highin democracy indices and was recently judged to be the fourth-most democratic country in the world according to Economist Intelligence (EIU 2022). Nonetheless, the

In the era of Industry 4.0, fostering innovation through strong collaboration among universities, industry, and government is crucial. However, the Tanzanian economy has faced challenges due to, among others, weak links between these entities. To address this, Sida initiated the Innovation Systems and Cluster Development Program (ISCP-Tz) in partnership with the University of Dar es Salaam. This w

Emergency fire situations in tunnels can be especially dangerous when occurring in long underground or subsea tunnels, particularly when evacuation on foot is the only alternative. This paper presents the results from a study comparing different visual and acoustic measures to facilitate efficient and safe emergency evacuation and their effect on people's self-rescue behaviour in response to a tun

In response to the rising needs for long-term research and innovation in the field of critical raw material exploration, the Smart Exploration Research Centre was established in 2024 in Sweden. Funded by the Swedish Foundation for Strategic Research (SSF), this initiative involves collaboration among academic institutions, industry, and the public sector. Building on the H2020-funded Smart Explora

Context. The HD 15337 (TIC 120896927, TOI-402) system was observed by the Transiting Exoplanet Survey Satellite (TESS), revealing the presence of two short-period planets situated on opposite sides of the radius gap. This offers an excellent opportunity to study theories of formation and evolution, as well as to investigate internal composition and atmospheric evaporation. Aims. We aim to constrai