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The cfr gene encodes the Cfr methyltransferase that primarily methylates C-8 in A2503 of 23S rRNA in the peptidyl transferase region of bacterial ribosomes. The methylation provides resistance to six classes of antibiotics of clinical and veterinary importance. The rlmN gene encodes the RlmN methyltransferase that methylates C-2 in A2503 in 23S rRNA and A37 in tRNA, but RlmN does not significantly

Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and perf

The wheel-rail system operates in an open environment where the weather condition varies constantly. In this laboratory study, an investigation using a pin-on-disc tribometer placed in a temperature-controlled room was conducted to examine the effect of subzero temperature and snow on friction and wear at the wheel-rail contact. In temperature range from 3 to-15 °C (without snow) friction and wear

Deciphering the genotype–phenotype map necessitates relating variation at the genetic level to variation at the phenotypic level. This endeavour is inherently limited by the availability of standing genetic variation, the rate of spontaneous mutation to novo genetic variants, and possible biases associated with induced mutagenesis. An interesting alternative is to instead rely on the environment a

That Florida is in the midst of an ecological crisis is a perspective increasingly shared by academy, government, private industry and civil society. Ideas about the causes of the state’s environmental problems and how best to address them, however, are not so well aligned. While some are prone to emphasize the primacy of economic growth over environmental conservation, others argue that, like lov

Background Breathlessness is associated with major adverse health outcomes and is twice as common in women as men in the general population. We evaluated whether this is related to their lower absolute lung volumes. Methods Cross-sectional analysis of the population-based Swedish CardioPulmonarybioImage Study (SCAPIS) Pilot, including static spirometry and diffusing capacity (n = 1,013; 49% women)

The list of Egyptian deities attested in Greek and demotic inscriptions in the sandstone quarries of Gebel el-Silsila comprises Amun, Horus, Hathor, Isis, Khnum, Montu, Pachimesen, and Shaï. Several new inscriptions and divine names are here added to previous records: the Egyptian gods Min, Bes, Tutu, and the Greek goddesses Athena and Tyche.

The prospects of domestic punishment might compel leaders responsible for the initiation of the war to continue fighting until they achieve favorable war outcomes (Croco 2011, 2015). As applied to war duration, this logic implies that ‘culpable’ leaders do not have incentives to end a war that will bring defeat. This paper argues that leaders can escape this dilemma by blaming and replacing their

Pancreatic cancer is known for its propensity to metastasize. Recent studies have challenged the commonly held belief that pancreatic cancer is a stepwise process, where tumor cells disseminate late in primary tumor development. Instead it has been suggested that pancreatic tumor cells may disseminate early and develop independently and in parallel to the primary tumor. Circulating tumor cells can

The principal aim of my PhD research is to think through practices involved in the making of In the Desert of Modernity. Colonial Planning and After (Berlin 2008, Casablanca 2009), that constituted as well as traversed the exhibitions and went beyond. The project developed through a transnational constellation of culture producers, scholars, and activists from Berlin, Zurich, Paris, Delft and Casa

Background: Several indirect calorimetry (IC) instruments are commercially available, but comparative validity and reliability data are lacking. Existing data are limited by inconsistencies in protocols, subject characteristics, or single-instrument validation comparisons. The aim of this study was to compare accuracy and reliability of metabolic carts using methanol combustion as the cross-labora

This paper examines organisational responses to eyewitness footage as a mediator in crisis communication. Eyewitness photographs and films is a growing genre of visuals that are difficult for organisations to respond to, because they are regarded as more authentic and true than other images of crisis events. In addition, it is here argued that widely circulated eyewitness imagery often involve ico

Before industrialisation the Nordic countries (Denmark, Finland, Norway and Sweden) were part of Europe's poor periphery, but over the last century these countries have become some of the richest in the world. This article analyses the origins of Nordic growth from the late nineteenth century, focusing on a previously neglected topic: the role of transportation. We argue that transportation, and m

PurposeSleep apnea syndrome (SAS) is a relatively common disorder, but many patients with SAS are still undiagnosed. Using Japanese annual health check and medical claims data, we analyzed the association between hemoglobin upswing, defined as an increase in hemoglobin level within the reference range, and the incidence of SAS.MethodsIn this study, we used the Japan Medical Database Center (JMDC)

Flood risk is a great global concern that is not only affecting developing countries, but threatens to undermine sustainable development also in the most affluent advanced liberal democracies. While political inertia is delaying much needed global change, efforts to reduce risk and adapt to a changing climate are growing on more local levels. However, floods tend not to be bounded by geopolitical,