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Laminins are basement membrane components that regulate a plethora of biological processes. Despite decades of research, the exact roles of laminins in different tissues and in organogenesis remain to be elucidated. Here, we investigated the function of laminin γ1 chain in heart, lung and other tissues by generating a mouse that lacks laminin γ1 in cells expressing SM22α (Tagln) (LMγ1 flox/SM22α C

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Performance of a proton exchange membrane (PEM) fuel cell is very sensitive to its electric resistance appearing in its functional components. In this paper, the electric resistance as well as related parameters of a cell is evaluated by a recently developed numerical method in the through-plane direction of the electrodes. The results show that the channel/rib structure leads to non-homogeneous e

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Corporate mergers and acquisitions (M&As) are prominent means for corporate strategy. In many M&As information systems (IS), integration is critical for achieving the intended goals. By integrating previous research on M&A and IS integration, we develop a six-dimensional theoretical framework for IS integration in corporate M&As. The framework is used to describe and explain IS int

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The adsorption from a mixture of SDS and β-Lactoglobulin, 1:5 (), onto a methylated silica surface was studied in situ by ellipsometry. The amounts adsorbed from different concentrations of the mixture, at pH 7, were compared with those adsorbed from the corresponding pure SDS and β-lactoglobulin solutions. At high concentrations of the mixture, where the CMC of SDS is approached or exceeded, the

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It has been often claimed that the scientific process is quite opposite to the design process, mainly based on the former’s analysis of existing phenomena in order to develop a theory, while the design process is an act of synthesis that creates something new in the world. In the light of the developments that led to this conception, and with reference to the current views of the scientific proces

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Paratransit services support individuals with limited mobility by providing access to healthcare, errands, and social activities. While designed to be enabling, these services impose temporal demands that require the user’s active engagement, such as booking in time and coordinating with other support services. This study explores how older users experience and manage the temporal dimensions of Sw

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As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. SMCs are highly specialized cells with the main fu

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Breast cancer is the most common type of cancer globally. Early detection is important for reducing the morbidity and mortality of breast cancer. The aim of this study was to evaluate the performance of different machine learning models to classify malignant or benign lesions on breast ultrasound images. Three different convolutional neural network approaches were implemented: (a) Simple convolut

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Purpose: To explore how the changes in work life, here represented and depicted through the concepts of knowledge work and knowledge worker, have been incorporated in the official psychosocial work environment discourse in Sweden. Methodology: Critical discourse analysis, contrasting the official psychosocial work environment discourse to literature on knowledge work and knowledge worker, to explo

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Background: The ageing population is increasing worldwide, and this trend is bringing challenges both for the older person and for society. In order to meet the challenges a comprehensive approach is needed involving both health promotion and risk prevention. The preventive home visit is a public health intervention used around the world with the purpose of promoting health and preventing risk amo