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Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular traits (36,203 UK Biobank participants). We identified 80 genomic risk loci and prioritized 62 putative effector genes, including several with rare variant DCM associations (MAP3K7, NEDD4L a

The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri

Ribbed channel flows play a crucial role in various engineering systems where turbulence enhancement and improved heat transfer are required, such as in turbine blade cooling and combustor wall applications. Numerical simulations have emerged as an essential tool for analyzing the intricate turbulence dynamics and flow separation phenomena, which are fundamental for optimizing the channel performa

We present a user study analyzing head-gaze- based robot control and foveated visual augmentation in a simulated search-and-rescue task. Results show that foveated augmentation significantly improves task performance, reduces cognitive load by 38%, and shortens task time by over 60%. Head-gaze patterns analysed over both the entire task duration and shorter time segments show that near and far att

This paper explores the dynamics of human-robot collaboration through a comparative study of human-assisted and system-assisted approaches in a search and rescue application. Leveraging virtual environments and mixed-reality interfaces, the study evaluates task performance, workload, usability, and subjective experiences of participants. Results indicate that the system-assisted approach significa

Background and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some cardiovascular complications from the vaccine itself have been demonstrated. Myocarditis and pericarditis are recognized as rare acute adverse events after mRNA vaccines in young males, while evidence regarding other cardiovascular events remains limit

Optical mapping by direct visualization of individual DNA molecules, stretched in nanochannels with sequence-specific fluorescent labeling, represents a promising tool for disease diagnostics and genomics. An important challenge for this technique is thermal motion of the DNA as it undergoes imaging; this blurs fluorescent patterns along the DNA and results in information loss. Correcting for this

Fifty knees scheduled for a total knee prosthesis were randomized in two groups. Both groups had a noncemented fixation of the porous-coated implants but one group received a prosthesis with ceramic coating on the porous surface of the implant. The knees were evaluated with RSA technique regarding micromotion the first two years. There were less micromotion in the coated group. The results indicat

The contiguity and phase of sequence information are intrinsic to obtain complete understanding of the genome and its relationship to phenotype. We report the fabrication and application of a novel nanochannel design that folds megabase lengths of genomic DNA into a systematic back-and-forth meandering path. Such meandering nanochannels enabled us to visualize the complete 5.7 Mbp (1mm) stained DN

Detta är introduktionskapitet till rapporten "DigiTrust: Tillit i det digitala. Tvärvetenskapliga perspektiv från ett forskningsprojekt", där forskargruppsledarna beskriver grunderna för projektet.

The risk of distant recurrence in breast cancer patients is difficult to assess with current clinical and histopathological parameters, and no validated serum biomarkers currently exist. Using a recently developed recombinant antibody microarray platform containing 135 antibodies against 65 mainly immunoregulatory proteins, we screened 240 sera from 64 patients with primary breast cancer. This uni

Ett koordinerat samarbete och tydlig kommunikation utgör grunden för en välfungerande projektering av ett byggprojekt. I det traditionella tillvägagångssättet utförs arbetet sekventiellt, där projektet passerar mellan de inblandade parterna i turordning. Detta linjära arbetsflöde leder ofta till fragmentering av projektdata och svårigheter att bibehålla en gemensam förståelse mellan inblandade parA coordinated collaboration and clear communication forms the foundation for a well-functioning construction project. In the traditional approach, the work is carried out sequentially, where the project is passed on from one involved party to the next. This linear work flow often leads to fragmentation of work data and difficulties in maintaining a common understanding of the project, which in tur

I takt med att miljö och hållbarhet blir alltmer prioriterade frågor för samhället kommer marknaden för biobränslen och energi producerad från biobränslen öka. Genom ökad konkurrens bland energiproducenter skapas ett större krav på lagerhantering som är en grundläggande kompetens för företag. Lager och lagerhanteringen har direkt påverkan på resultatet och därmed hur konkurrenskraftigt företaget ä

Den svenska bostadsmarknaden präglas av en bostadsbristsituation, en situation som enligt Boverket förvärrats av omvärldshändelser som covid-19 och kriget i Ukraina. Det är i denna kontext intressant att undersöka orsaken och implikationerna av observerade skillnader i belåningsgrad och marknadsvärdestillväxt mellan kommunala bostadsbolag och privata fastighetsbolag. Syftet med arbetet är att unIn Sweden it has for many years been the common understanding that there is a shortage of housing on the housing market, a situation that according to Boverket has been further worsened by recent world events such as the Covid-19 pandemic and the Russian war of aggression against Ukraine. In this context it was interesting to study the cause of and implications of observed differences in the grow

Att undersöka stjärnor i infrarött är en relativt ny företeelse till skillnad från optisk astronomi (dvs. synligt ljus). Det var först på 60-talet med teleskopet Stratoscope II som man lyckades få spektra från stjärnor i infrarött (våglängder på runt 3 m), och upptäckte förekomsten av vatten i kalla röda jättar. Den bakomliggade problematiken till varför modern infraröd astronomi är så ungt är våThe advent of infrared astronomy, unlike optical astronomy that was developed over centuries, was delayed until the space age due to our own atmosphere acting as an efficient shield towards this radiation. With a lot of molecules (including water) emitting in the infrared region, it was first in the late 1990s that water no longer was deemed special and was observed in many cooler (K-M) giant star

Lean, premixed, swirl-stabilized flames are widely used in modern Dry Low Emissions gas turbine combustors; however, the turbulent combustion process under those conditions is known to be extremely sensitive and prone to instabilities. Numerical simulations can be a valuable tool in predicting the effects of alternative fuels; however, the sensitivity of the results to different models ought to be

Background: The incorporation of artificial intelligence (AI) into point-of-care ultrasound (POCUS) platforms has rapidly increased. The number of B-lines present on lung ultrasound (LUS) serve as a useful tool for the assessment of pulmonary congestion. Interpretation, however, requires experience and therefore AI automation has been pursued. This study aimed to test the agreement between the AI

BACKGROUND: Fast-track referral is an increasingly used method for diagnostic evaluation of patients suspected of having cancer. This approach is challenging and not used as often for patients with only nonspecific symptoms. In order to expedite the diagnostics for these patients, we established Sweden's first Diagnostic Center (DC) focusing on outcomes related to diagnoses and diagnostic time int

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified