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Randomized clinical trials are the preferred study design to address key research questions about the benefits or harms of interventions. However, randomized trials of oxygen therapy are difficult to conduct and have limitations. The purpose of this article is to offer our view on the potential use of patient registries in the field of home oxygen in COPD as an alternative to randomized trials by
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Background: Numerous different types of variations can occur in DNA and have diverse effects and consequences. The Variation Ontology (VariO) was developed for systematic descriptions of variations and their effects at DNA, RNA and protein levels. Results: VariO use and terms for DNA variations are described in depth. VariO provides systematic names for variation types and detailed descriptions fo
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The Arctic is often perceived as the new resource frontier in a resource hungry world. Many actors both inside and outside the region are eager to know what opportunities lie under the ice, and many claim a say in the future development of the Arctic. In Greenland, a national economy based on natural resources will lessen the dependence on the former colonial power Denmark. Many consider this an i
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Photovoltaics is amongst the most important technologies for renewable energy sources, and plays a key role in the development of a society with a smaller environmental footprint. Key parameters for solar cells are their energy conversion efficiency, their operating lifetime, and the cost of the energy obtained from a photovoltaic system compared to other sources. The optimization of these aspects
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Modern programs make extensive use of reusable software libraries. For example, a study of a number of large Java applications shows that between 17% and 30% of the classes in those applications use container classes defined in the java.util package. Given this extensive code reuse in Java programs, it is important for the interfaces of reusable classes to be well documented. An interface is well
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This book summarizes various approaches for the automatic detection of health threats to older patients at home living alone. The text begins by briefly describing those who would most benefit from healthcare supervision. The book then summarizes possible scenarios for monitoring an older patient at home, deriving the common functional requirements for monitoring technology. Next, the work identif
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The Common Agricultural Policy (CAP) is the largest budget item in the European Union, but varied data reporting hampers holistic analysis. Here we have assembled the first dataset to our knowledge to report individual CAP payments by standardized CAP funding measures and geolocation. We created this dataset by translating, geolocating to the county or province (NUTS3) level, and consistently harm
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Kidney Exchange Programs (KEP) are valuable tools to increase the options of living donor kidney transplantation for patients with end-stage kidney disease with an immunologically incompatible live donor. Maximising the benefits of a KEP requires an information system to manage data and to optimise transplants. The data input specifications of the systems that relate to key information on blood gr
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A new integral equation formulation is presented for the Maxwell transmission problem in Lipschitz domains. It builds on the Cauchy integral for the Dirac equation, is free from false eigenwavenumbers for a wider range of permittivities than other known formulations, can be used for magnetic materials, is applicable in both two and three dimensions, and does not suffer from any low-frequency break
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Where is the world really heading, and what can we do about it? This book, edited by the Arkbound Foundation, takes an unflinching look at climate change – drawing upon the latest data to analyse what the next decades hold in store. With atmospheric CO2 at unprecedented levels and insufficient action being taken to prevent a rise in temperatures above 2 degrees centigrade, we are not just looking
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Simultaneous detection of multiple signals for common biochemical/electrochemical reactions is a challenging area of research for comparative studies. Based on our previous work with electrochemically assisted thermal biosensors, a hybrid biosensor has been developed for the simultaneous monitoring of the electrochemically generated current and the thermal signal produced in association with enzym
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A rationale for an individuals-oriented landscape approach to sustainable land-use planning based on an analysis of bio-geo-physical components as well as the human components of the landscape is presented. A toolbox for analysing individuals’ decision-making and valuations in the landscape is described. The toolbox can provide evidence on the drivers of individuals’ decision-making in the landsca
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The confidentiality and integrity algorithms in cellular networks protect the transmission of user and signaling data over the air between users and the network, e.g., the base stations. There are three standardised cryptographic suites for confidentiality and integrity protection in 4G, which are based on the AES, SNOW 3G, and ZUC primitives, respectively. These primitives are used for providing
