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Pituitary tumours, originating from endocrine cells of the anterior pituitary, are quite common, and in most cases well-controlled by surgery or medical treatment. However, a small subset of pituitary tumours presents with multiple local recurrences or tumour progression despite combined surgical, medical or radiotherapeutic treatment. These are known as aggressive pituitary tumours (APT); also ca
Artificial intelligence (AI) methods are powerful tools for biological image analysis and processing. High-quality annotated images are key to training and developing new algorithms, but access to such data is often hindered by the lack of standards for sharing datasets. We discuss the barriers to sharing annotated image datasets and suggest specific guidelines to improve the reuse of bioimages an
The intervention Balancing Everyday Life™ (BEL) helps service users achieve a balance among everyday activities and enhance personal recovery. BEL builds upon research for people with mental illness and on evidence from earlier activity-based interventions. This methodological paper presents the theoretical basis for BEL, which rests on five pillars of theories and models. Further, the BEL topics
Accurate assessments of symptoms and illnesses are essential for health research and clinical practice but face many challenges. The absence of a single error-free measure is currently addressed by assessment methods involving experts reviewing several sources of information to achieve a best-estimate assessment. This assessment method is called the Expert Panel method in medicine, and the Best-Es
In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanoc
School-related functional impairment is common in children and adolescents with obsessive-compulsive disorder (OCD). However, little is known about the characteristics of youth with OCD who struggle in school, whether these struggles interfere with treatment outcomes, and whether treatment improves school-related function. Among 385 youth with OCD at a specialist clinic (mean age [sd] = 13.7 [2.5]
Purpose: Adolescent and young adult (AYA) cancer survivors have unique psychological needs and require tailored support, as they transition from hospital settings following cancer treatment. This study aimed to evaluate the safety and clinical effectiveness of the online "Recapture Life" program to improve AYA aged survivors' psychological adjustment in early cancer survivorship. Methods: The inte
This thesis discusses the use of standards in land-use planning risk management regulations. Based on exploring the domains of standards and standardisation, risk science, and risk management regulations, the research contributes significant empirical evidence capturing the perspectives of risk managementpractitioners in terms of the strengths, the weaknesses and the effects of using standards in
One of the main challenges in regenerative medicine is the spatiotemporal control of angiogenesis, which is key for the successful repair of many tissues, and determines the proper integration of the implant through the generation of a functional vascular network. To this end, we have designed a three-dimensional (3D) model consisting of a coaxial binary elastin-like recombinamer (ELR) tubular con
In the effort to obtain a precise measurement of leptonic CP-violation with the ESSνSB experiment, accurate and fast reconstruction of detector events plays a pivotal role. In this work, we examine the possibility of replacing the currently proposed likelihood-based reconstruction method with an approach based on Graph Neural Networks (GNNs). As the likelihood-based reconstruction method is reason
We study the realizability and strong satisfiability problems for SAFETY LTL, a syntactic fragment of Linear Temporal Logic ([Formula presented]) capturing safe formulas. While it is well-known that realizability for this fragment lies in [Formula presented], the best-known lower bound is [Formula presented]-hardness. Surprisingly, closing this gap has proven an elusive task. Previous works have c
Introduction: Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been performed to assess t
This chapter is about digital advocacy and civil society in the era of Artificial Intelligence (AI). Social media has often been discussed as a game-changer when it comes to advocacy. The technical structures of social media are continuously changing and, therefore, so are the conditions for digital advocacy. Extensive research has focused on different digital advocacy strategies. However, there h
Background: Negative affective processes may contribute to maintenance of paranoia in patients with psychosis, and vice versa. Successful treatment may break these pathological symptom networks. This study examined whether treatment with virtual reality based cognitive behavioral therapy (VR-CBT) for paranoia influences momentary affective states, and whether VR-CBT changes the adverse interplay b
This essay delves into the akiya (vacant houses) problem in Japan, using the phenomenon as a lens to discuss the larger issue of depopulation and repopulation of regional Japan. It builds on ethnographic fieldwork conducted in Kochi Prefecture from February to April, 2023, where semi-structured interviews were conducted with official workers and local residents of depopulated areas. The study find
Panel for Pollen Conference in Lund 2024Exploring transitions for marine environmental governance: the potential of communities and bottom-up processes as alternative pathways to sustainabilityFacilitating the potential of communities and bottom-up governance for transitions to sustainability (T2S) sparks key questions of political ecology. Marine environmental governance exposes such challenges r
Background People living with serious respiratory illness experience a high burden of distressing symptoms. Although opioids are prescribed for symptom management, they generate adverse events, and their benefits are unclear. Methods We examined the efficacy and safety of opioids for symptom management in people with serious respiratory illness. Embase, MEDLINE and the Cochrane Central Register of
Education reduces the intergenerational transfer of poverty and boosts growth according to the Social Investment (SI) approach (Morel, Palier, and Palme 2011). However, educational systems differ in their capacity to promote equality and produce the skills needed in today‘s knowledge economies. Despite extensive scholarship on how education policies vary in terms of their social and economic effec
The longitudinal motion and the intramural shear strain of the arterial wall increase dramatically in response to blood pressure, thereby impacting the vascular wall microenvironment. Exposure to a sedentary lifestyle has been identified as an independent risk factor for cardiovascular disease, but it has been shown that intermittent physical activity embedded into everyday life is enough to impro
